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bcrC undecaprenyl pyrophosphate phosphatase (bacitracin resistance) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 936946, updated on 6-Jun-2024

Summary

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Gene symbol
bcrC
Gene description
undecaprenyl pyrophosphate phosphatase (bacitracin resistance)
Locus tag
BSU_36530
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU36530
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Genomic context

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Sequence:
NC_000964.3 (3758547..3759128)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene ammonium transporter Neighboring gene nitrogen-regulated PII-like regulator protein Neighboring gene putative integral inner membrane protein Neighboring gene forespore protein required for alternative engulfment

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of Undecaprenyl Pyrophosphate Phosphatases Disrupts Cell Envelope Biogenesis in Bacillus subtilis. Zhao H, et al. J Bacteriol, 2016 Nov 1. PMID 27528508, Free PMC Article
  2. BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance. Bernard R, et al. J Biol Chem, 2005 Aug 12. PMID 15946938
  3. Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: implications for the mechanism of resistance mediated by the BceAB transporter. Kingston AW, et al. Mol Microbiol, 2014 Jul. PMID 24806199, Free PMC Article
  4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B. subtilis requires either of two UPP phosphatases, UppP or BcrC, for viability.
    Title: Depletion of Undecaprenyl Pyrophosphate Phosphatases Disrupts Cell Envelope Biogenesis in Bacillus subtilis.
  2. Results show that in the abscence of YtpB, heptaprenyl diphosphate accumulates and antagonizes both enzymes BceAB and BcrC sensitizing the bacteria to bacitracin.
    Title: Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: implications for the mechanism of resistance mediated by the BceAB transporter.
  3. BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance
    Title: BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
undecaprenyl pyrophosphate phosphatase (bacitracin resistance)
NP_391534.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_391534.1 undecaprenyl pyrophosphate phosphatase (bacitracin resistance) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_391534.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    D4G2H1
    Conserved Domains (1) summary
    cd03385
    Location:19 → 161
    PAP2_BcrC_like; PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P94571.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases