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KIF3B kinesin family member 3B [ Homo sapiens (human) ]

Gene ID: 9371, updated on 21-Apr-2024

Summary

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Official Symbol
KIF3Bprovided by HGNC
Official Full Name
kinesin family member 3Bprovided by HGNC
Primary source
HGNC:HGNC:6320
See related
Ensembl:ENSG00000101350 MIM:603754; AllianceGenome:HGNC:6320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLA8; RP89; HH0048; KLP-11; OTSC12
Summary
The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 22.2), kidney (RPKM 21.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
20q11.21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32277651..32335011)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34001508..34059883)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30865454..30922814)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene protein O-fucosyltransferase 1 Neighboring gene microRNA 1825 Neighboring gene NANOG hESC enhancer GRCh37_chr20:30858165-30858696 Neighboring gene uncharacterized LOC124904885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30865306-30865816 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:30914131-30915330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17716 Neighboring gene ASXL transcriptional regulator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31033225-31033886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31035799-31036300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31044389-31045304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31045305-31046220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31046221-31047136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31062343-31063114 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31064659-31065430 Neighboring gene nucleolar protein 4 like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12790 Neighboring gene uncharacterized LOC124904886

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KIF3B gene silent variant leading to sperm morphology and motility defects and male infertility†. Heydari R, et al. Biol Reprod, 2022 Apr 26. PMID 34918036
  2. Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression. Gu R, et al. Technol Cancer Res Treat, 2020 Jan-Dec. PMID 33153390, Free PMC Article
  3. Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer. Yao FZ, et al. Kaohsiung J Med Sci, 2020 Jul. PMID 32237034
  4. KIF3B Promotes the Proliferation of Pancreatic Cancer. Liu ZH, et al. Cancer Biother Radiopharm, 2019 Aug. PMID 31157987
  5. A novel role of KIF3b in the seminoma cell cycle. Shen HQ, et al. Exp Cell Res, 2017 Mar 1. PMID 28161539

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF3B gene silent variant leading to sperm morphology and motility defects and male infertilitydagger.
    Title: KIF3B gene silent variant leading to sperm morphology and motility defects and male infertility†.
  2. Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression.
    Title: Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression.
  3. Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
    Title: Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
  4. LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.
    Title: LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.
  5. Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
    Title: Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
  6. miR-127-3p was downregulated in oral squamous cell carcinoma (OSCC) tissues and was associated with malignant clinicopathological features and poor prognosis. KIF3B was confirmed to be a direct target of miR-127-3p. Upregulation of KIF3B observed in OSCC promoted tumorigenesis. miR-127-3p targeted KIF3B to inhibit the development of OSCC by suppressing cell proliferation, migration and invasion.
    Title: MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.
  7. Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia.
    Title: Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.
  8. High KIF3B expression is associated with Pancreatic Cancer.
    Title: KIF3B Promotes the Proliferation of Pancreatic Cancer.
  9. The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport.
    Title: Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.
  10. High KIF3B expression is associated with seminoma.
    Title: A novel role of KIF3b in the seminoma cell cycle.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Retinitis pigmentosa 89
MedGen: C5394552 OMIM: 618955 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0359

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intraciliary transport particle B binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in anterograde dendritic transport of neurotransmitter receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of left/right symmetry TAS
Traceable Author Statement
more info
 PubMed 
involved_in intraciliary transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic centrosome separation TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in opsin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plus-end-directed vesicle transport along microtubule TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in ciliary tip TAS
Traceable Author Statement
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium TAS
Traceable Author Statement
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
part_of kinesin II complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
part_of plus-end kinesin complex TAS
Traceable Author Statement
more info
 PubMed 
colocalizes_with spindle microtubule NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF3B
Names
microtubule plus end-directed kinesin motor 3B
NP_004789.1
XP_047296545.1
XP_047296546.1
XP_054180203.1
XP_054180204.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004798.4 → NP_004789.1  kinesin-like protein KIF3B

    See identical proteins and their annotated locations for NP_004789.1

    Status: REVIEWED

    Source sequence(s)
    AB002357, AL121897, AL353976, AL354800, BC136311, DA805755
    Consensus CDS
    CCDS13200.1
    UniProtKB/Swiss-Prot
    B2RMP4, B4DSR5, E1P5M5, O15066
    Related
    ENSP00000364864.3, ENST00000375712.4
    Conserved Domains (2) summary
    COG1196
    Location:352 → 614
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01371
    Location:8 → 340
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    32277651..32335011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440590.1 → XP_047296546.1  kinesin-like protein KIF3B isoform X1

    UniProtKB/Swiss-Prot
    B2RMP4, B4DSR5, E1P5M5, O15066

  2. XM_047440589.1 → XP_047296545.1  kinesin-like protein KIF3B isoform X1

    UniProtKB/Swiss-Prot
    B2RMP4, B4DSR5, E1P5M5, O15066

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    34001508..34059883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324229.1 → XP_054180204.1  kinesin-like protein KIF3B isoform X1

    UniProtKB/Swiss-Prot
    B2RMP4, B4DSR5, E1P5M5, O15066

  2. XM_054324228.1 → XP_054180203.1  kinesin-like protein KIF3B isoform X1

    UniProtKB/Swiss-Prot
    B2RMP4, B4DSR5, E1P5M5, O15066
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15066.1 GenPept UniProtKB/Swiss-Prot:O15066

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