TSIX TSIX transcript, XIST antisense RNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: TSIXprovided by HGNC
Official Full Name: TSIX transcript, XIST antisense RNAprovided by HGNC
Primary source: HGNC:HGNC:12377
See related: Ensembl:ENSG00000270641 MIM:300181; AllianceGenome:HGNC:12377
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: XISTAS; XIST-AS; XIST-AS1; LINC00013; NCRNA00013
Summary: In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. The mouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xist through modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivation does not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression or affect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend over more than 30 kb, but its exact nature has not been determined. [provided by RefSeq, Jul 2008]
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Genomic context

Location:: Xq13.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (73792205..73829231)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (72225527..72262546)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (73012040..73049066)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysregulation in the expression of (lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283) in spinal cord injury.
Title: Dysregulation in the expression of (lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283) in spinal cord injury.
Authors selected an HCC-specific RNA-based biomarker panel that depended on the integration of suppressor of glucose autophagy-associated (SOGA1) gene expression with the chosen panel of epigenetic regulators of this gene [long non-coding RNA antisense for X-inactive-specific transcript (lncRNA-TSIX) and microRNA-548-a-3p (miR-548-a-3p)].
Title: Potential role of lncRNA-TSIX, miR-548-a-3p, and SOGA1 mRNA in the diagnosis of hepatocellular carcinoma.
TSIX is overexpressed in systemic sclerosis dermal fibroblasts in vivo and in vitro, and is higher in SSc sera. TSIX is a new regulator of collagen expression and stabilizes its mRNA. TSIX upregulation may result from activated endogenous TGF-beta signaling.
Title: Long non-coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization.
Tsix is not required at the onset of random X-inactivation; instead, it protects the active-X from ectopic silencing once X-inactivation has commenced.
Title: A Primary Role for the Tsix lncRNA in Maintaining Random X-Chromosome Inactivation.
It's proposed that Tsix and CTCF together establish a regulatable epigenetic switch for X-inactivation
Title: CTCF, a candidate trans-acting factor for X-inactivation choice.
comparison with mouse counterpart; gene expression
Title: Identification of TSIX, encoding an RNA antisense to human XIST, reveals differences from its murine counterpart: implications for X inactivation.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

DXS9733 (e-PCR)
- UniSTS:29189

GDB:454788 (e-PCR)
- UniSTS:157448

GDB:265297 (e-PCR)
- UniSTS:99368

DXS7717 (e-PCR)
- UniSTS:45136

RH18196 (e-PCR)
- UniSTS:41301

G20784 (e-PCR)
- UniSTS:67677

A006G16 (e-PCR)
- UniSTS:67678

PMC24149P16 (e-PCR)
- UniSTS:272227

PMC24149P17 (e-PCR)
- UniSTS:272228

1206 (e-PCR)
- UniSTS:39524

RH47941 (e-PCR)
- UniSTS:12915

DXS8235 (e-PCR)
- UniSTS:98974

DXS9733 (e-PCR)
- UniSTS:26309

GDB:190003 (e-PCR)
- UniSTS:155606

Other Names

TSIX transcript, XIST antisense RNA (non-protein coding)
X (inactive)-specific transcript, antisense (non-protein coding)
XIST antisense RNA (non-protein coding)
long intergenic non-protein coding RNA 13
x-inactivation-specific transcript-antisense

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.