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Brwd1 bromodomain and WD repeat domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 93871, updated on 28-Oct-2024

Summary

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Official Symbol
Brwd1provided by MGI
Official Full Name
bromodomain and WD repeat domain containing 1provided by MGI
Primary source
MGI:MGI:1890651
See related
Ensembl:ENSMUSG00000022914 AllianceGenome:MGI:1890651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr9; repro5; G1-403-16; 5330419I02Rik; D530019K20Rik
Summary
Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human BRWD1 (bromodomain and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 12.4), CNS E11.5 (RPKM 12.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Brwd1 in Genome Data Viewer
Location:
16 C4; 16 56.77 cM
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (95793289..95883905, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (95992089..96082703, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1600002D24 gene Neighboring gene predicted gene, 41508 Neighboring gene STARR-positive B cell enhancer ABC_E1930 Neighboring gene STARR-seq mESC enhancer starr_41608 Neighboring gene STARR-seq mESC enhancer starr_41610 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96212367-96212668 Neighboring gene STARR-seq mESC enhancer starr_41611 Neighboring gene proteasome (prosome, macropain) assembly chaperone 1 Neighboring gene STARR-seq mESC enhancer starr_41612 Neighboring gene STARR-seq mESC enhancer starr_41614 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:96307304-96307505 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96331382-96331682 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96349246-96349547 Neighboring gene high mobility group nucleosomal binding domain 1 Neighboring gene guided entry of tail-anchored proteins factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability. Pattabiraman S, et al. J Cell Biol, 2015 Jan 5. PMID 25547156, Free PMC Article
  2. The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition. Philipps DL, et al. Dev Biol, 2008 May 1. PMID 18353305, Free PMC Article
  3. Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21. Ramos VC, et al. Biochim Biophys Acta, 2002 Sep 27. PMID 12359327
  4. BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis. Mandal M, et al. Nat Commun, 2018 Sep 24. PMID 30250168, Free PMC Article
  5. Histone reader BRWD1 targets and restricts recombination to the Igk locus. Mandal M, et al. Nat Immunol, 2015 Oct. PMID 26301565, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study data indicate that, in both mice and humans, BRWD1 is a master orchestrator of enhancer accessibility that cooperates with transcription factor networks to drive late B-cell development.
    Title: BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis.
  2. BRWD1 is essential in females for epigenetic control of meiotic chromosome stability and in males for haploid gene transcription during postmeiotic sperm differentiation.
    Title: Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.
  3. Brwd1 represents one of a small number of genes whose elimination disrupts gametogenesis in both sexes after the major events of meiotic prophase I have been completed.
    Title: The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition.
  4. WDR9 is a transcriptional regulator involved in chromatin remodeling through the action of two bromodomains and contacts to the SWI/SNF complex
    Title: Expression of the Wdr9 gene and protein products during mouse development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bromodomain and WD repeat-containing protein 1
Names
WD repeat domain 9
WD repeat-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103179.1 → NP_001096649.1  bromodomain and WD repeat-containing protein 1 isoform B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and CDS compared to variant 1. The resulting isoform (B) is shorter and has a unique C-terminus compared to isoform A.
    Source sequence(s)
    AJ292468, AK030493, AK051870, AK162170, CA561282, CF162350, CV558558
    UniProtKB/Swiss-Prot
    Q921C3
    UniProtKB/TrEMBL
    Q3TSA7, Q8BPZ1
    Conserved Domains (5) summary
    cd05496
    Location:1317 → 1433
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:1150 → 1265
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    COG2319
    Location:181 → 540
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:178 → 497
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:189 → 226
    7WD40; WD40 repeat [structural motif]

  2. NM_145125.3 → NP_660107.2  bromodomain and WD repeat-containing protein 1 isoform A

    See identical proteins and their annotated locations for NP_660107.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AJ292467, AK027961, AK030493, AK051870, AW542089, CF162350, CV558558
    Consensus CDS
    CCDS49923.1
    UniProtKB/Swiss-Prot
    E9QAC1, Q921C2, Q921C3
    Related
    ENSMUSP00000097101.3, ENSMUST00000099502.9
    Conserved Domains (5) summary
    cd05496
    Location:1317 → 1433
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:1150 → 1265
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    COG2319
    Location:181 → 540
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:178 → 497
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:189 → 226
    7WD40; WD40 repeat [structural motif]

  3. NM_176928.1 → NP_795902.1  bromodomain and WD repeat-containing protein 1 isoform C

    See identical proteins and their annotated locations for NP_795902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and CDS compared to variant 1. The resulting isoform (C) is much shorter and has a unique C-terminus compared to isoform A.
    Source sequence(s)
    AK051870, BB272960
    Consensus CDS
    CCDS49922.1
    UniProtKB/TrEMBL
    Q8BPZ1
    Related
    ENSMUSP00000109458.2, ENSMUST00000113827.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    95793289..95883905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523113.3 → XP_006523176.1  bromodomain and WD repeat-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006523176.1

    Related
    ENSMUSP00000023631.9, ENSMUST00000023631.17
    Conserved Domains (5) summary
    cd05496
    Location:1317 → 1433
    Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd05529
    Location:1150 → 1265
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd00200
    Location:178 → 497
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:189 → 226
    7WD40; WD40 repeat [structural motif]
    pfam15402
    Location:2334 → 2507
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

RNA

  1. XR_004939257.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921C3.2 GenPept UniProtKB/Swiss-Prot:Q921C3

Gene LinkOut

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