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Pcdhb12 protocadherin beta 12 [ Mus musculus (house mouse) ]

Gene ID: 93883, updated on 2-Nov-2024

Summary

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Official Symbol
Pcdhb12provided by MGI
Official Full Name
protocadherin beta 12provided by MGI
Primary source
MGI:MGI:2136747
See related
Ensembl:ENSMUSG00000043458 AllianceGenome:MGI:2136747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcdh3; PcdhbL; Pcdhb5F
Summary
Predicted to be involved in cell adhesion. Located in cell-cell junction. Orthologous to human PCDHB5 (protocadherin beta 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Pcdhb12 in Genome Data Viewer
Location:
18 19.49 cM; 18 B3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37568674..37571707)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37435621..37438654)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene protocadherin beta 11 Neighboring gene predicted gene, 20162 Neighboring gene protocadherin beta 13 Neighboring gene protocadherin beta 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, expression, and chromosomal localization of a novel cadherin-related protein, protocadherin-3. Sago H, et al. Genomics, 1995 Oct 10. PMID 8575755
  2. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. Vanhalst K, et al. FEBS Lett, 2001 Apr 20. PMID 11322959
  3. CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. Elbert A, et al. J Neurosci, 2019 Jan 2. PMID 30377227, Free PMC Article
  4. Clustered gamma-protocadherins regulate cortical interneuron programmed cell death. Mancia Leon WR, et al. Elife, 2020 Jul 7. PMID 32633719, Free PMC Article
  5. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Wu Q, et al. Genome Res, 2001 Mar. PMID 11230163, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
protocadherin beta 12
Names
protocadherin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053137.2 → NP_444367.1  protocadherin beta 12 precursor

    See identical proteins and their annotated locations for NP_444367.1

    Status: VALIDATED

    Source sequence(s)
    AV286502, AY013773, BB617431, CJ132664
    Consensus CDS
    CCDS79621.1
    UniProtKB/TrEMBL
    A0PJT6, F6V243, Q91Y07
    Related
    ENSMUSP00000050357.7, ENSMUST00000055495.6
    Conserved Domains (3) summary
    cd11304
    Location:240 → 335
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:24 → 105
    Cadherin_2; Cadherin-like
    pfam16492
    Location:680 → 762
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    37568674..37571707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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