U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pcdhb21 protocadherin beta 21 [ Mus musculus (house mouse) ]

Gene ID: 93892, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Pcdhb21provided by MGI
Official Full Name
protocadherin beta 21provided by MGI
Primary source
MGI:MGI:2136759
See related
Ensembl:ENSMUSG00000044022 AllianceGenome:MGI:2136759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PcdhbU; Pcdhb18
Summary
Predicted to be involved in cell adhesion. Predicted to be active in plasma membrane. Is expressed in brain and embryo. Orthologous to several human genes including PCDHB18P (protocadherin beta 18 pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pcdhb21 in Genome Data Viewer
Location:
18 B3; 18 19.51 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37646678..37650260)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37513652..37516363)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene STARR-seq mESC enhancer starr_44310 Neighboring gene STARR-seq mESC enhancer starr_44311 Neighboring gene protocadherin beta 19 Neighboring gene protocadherin beta 20 Neighboring gene protocadherin beta 22 Neighboring gene STARR-seq mESC enhancer starr_44313 Neighboring gene STARR-seq mESC enhancer starr_44314 Neighboring gene solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A unique role of cohesin-SA1 in gene regulation and development. Remeseiro S, et al. EMBO J, 2012 May 2. PMID 22415368, Free PMC Article
  2. Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Remeseiro S, et al. Biochim Biophys Acta, 2013 Dec. PMID 23920377, Free PMC Article
  3. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. Vanhalst K, et al. FEBS Lett, 2001 Apr 20. PMID 11322959
  4. Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Gendrel AV, et al. Mol Cell Biol, 2013 Aug. PMID 23754746, Free PMC Article
  5. CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. Elbert A, et al. J Neurosci, 2019 Jan 2. PMID 30377227, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protocadherin beta 21

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053146.3 → NP_444376.1  protocadherin beta 21 precursor

    See identical proteins and their annotated locations for NP_444376.1

    Status: VALIDATED

    Source sequence(s)
    AC020967
    Consensus CDS
    CCDS29186.1
    UniProtKB/TrEMBL
    Q3UYA2, Q91V48
    Related
    ENSMUSP00000056424.5, ENSMUST00000061405.6
    Conserved Domains (4) summary
    cd11304
    Location:245 → 341
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:370 → 448
    CA; Cadherin repeats
    pfam08266
    Location:30 → 110
    Cadherin_2; Cadherin-like
    pfam16492
    Location:687 → 769
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    37646678..37650260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools