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B3galt5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 [ Mus musculus (house mouse) ]

Gene ID: 93961, updated on 2-Nov-2024

Summary

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Official Symbol
B3galt5provided by MGI
Official Full Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5provided by MGI
Primary source
MGI:MGI:2136878
See related
Ensembl:ENSMUSG00000074892 AllianceGenome:MGI:2136878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b3Galt-V; 1190002B21Rik
Summary
Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Acts upstream of or within response to bacterium. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and visual system. Orthologous to human B3GALT5 (beta-1,3-galactosyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 35.5), cerebellum adult (RPKM 6.1) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See B3galt5 in Genome Data Viewer
Location:
16 C4; 16 56.88 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (96037001..96121059)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (96235801..96319859)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Leber congenital amaurosis 5-like Neighboring gene STARR-positive B cell enhancer ABC_E7483 Neighboring gene predicted gene, 53923 Neighboring gene SH3-binding domain glutamic acid-rich protein Neighboring gene STARR-seq mESC enhancer starr_41616 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:96495129-96495238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:96514185-96514338 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96562962-96563262 Neighboring gene predicted gene, 41510 Neighboring gene immunoglobulin superfamily, member 5 Neighboring gene integrin beta 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase. Zhou D, et al. J Biol Chem, 2000 Jul 28. PMID 10837462
  2. Endogenous retrovirus long terminal repeats as ready-to-use mobile promoters: the case of primate beta3GAL-T5. Dunn CA, et al. Gene, 2005 Dec 30. PMID 16112824
  3. Developmental regulation of beta-1,3-galactosyltransferase-1 gene expression in mouse brain. Zhu D, et al. FEBS Lett, 2003 Mar 13. PMID 12633872
  4. Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon. Taniguchi M, et al. Mucosal Immunol, 2023 Oct. PMID 37385587
  5. Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21. Pletcher MT, et al. Genomics, 2001 May 15. PMID 11374901

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. case study of the endogenous retrovirus long terminal repeat promoter of this enzyme, beta1,3-galactosyltransferase 5
    Title: Endogenous retrovirus long terminal repeats as ready-to-use mobile promoters: the case of primate beta3GAL-T5.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,3-galactosyltransferase 5
Names
SSEA-3 synthase
UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
b3Gal-T5
beta-1,3-GalTase 5
beta-3-Gx-T5
beta3Gal-T5
beta3GalT5
stage-specific embryonic antigen 3 synthase
NP_001116465.1
NP_001345318.1
NP_001345319.1
NP_149161.1
XP_006523180.1
XP_036016084.1
XP_036016085.1
XP_036016086.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122993.1 → NP_001116465.1  beta-1,3-galactosyltransferase 5

    See identical proteins and their annotated locations for NP_001116465.1

    Status: VALIDATED

    Source sequence(s)
    AC154258, AK004442, BC047347, BY124193
    Consensus CDS
    CCDS28356.1
    UniProtKB/Swiss-Prot
    Q9JI67
    Related
    ENSMUSP00000109431.3, ENSMUST00000113800.9
    Conserved Domains (1) summary
    cl21608
    Location:69 → 259
    Galactosyl_T; Galactosyltransferase

  2. NM_001358389.1 → NP_001345318.1  beta-1,3-galactosyltransferase 5

    Status: VALIDATED

    Source sequence(s)
    AC154258, AC165170
    Consensus CDS
    CCDS28356.1
    UniProtKB/Swiss-Prot
    Q9JI67
    Conserved Domains (1) summary
    cl21608
    Location:69 → 259
    Galactosyl_T; Galactosyltransferase

  3. NM_001358390.1 → NP_001345319.1  beta-1,3-galactosyltransferase 5

    Status: VALIDATED

    Source sequence(s)
    AC154258, AC165170
    Consensus CDS
    CCDS28356.1
    UniProtKB/Swiss-Prot
    Q9JI67
    Conserved Domains (1) summary
    cl21608
    Location:69 → 259
    Galactosyl_T; Galactosyltransferase

  4. NM_033149.3 → NP_149161.1  beta-1,3-galactosyltransferase 5

    See identical proteins and their annotated locations for NP_149161.1

    Status: VALIDATED

    Source sequence(s)
    AC154258, AK004442, BC047347, BY124193, DN172993
    Consensus CDS
    CCDS28356.1
    UniProtKB/Swiss-Prot
    Q9JI67
    Related
    ENSMUSP00000097096.4, ENSMUST00000099497.4
    Conserved Domains (1) summary
    cl21608
    Location:69 → 259
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    96037001..96121059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523117.2 → XP_006523180.1  beta-1,3-galactosyltransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006523180.1

    UniProtKB/Swiss-Prot
    Q9JI67
    Conserved Domains (1) summary
    cl21608
    Location:69 → 259
    Galactosyl_T; Galactosyltransferase

  2. XM_036160191.1 → XP_036016084.1  beta-1,3-galactosyltransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9JI67
    Conserved Domains (1) summary
    cl21608
    Location:69 → 259
    Galactosyl_T; Galactosyltransferase

  3. XM_036160193.1 → XP_036016086.1  beta-1,3-galactosyltransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9JI67
    Conserved Domains (1) summary
    cl21608
    Location:69 → 259
    Galactosyl_T; Galactosyltransferase

  4. XM_036160192.1 → XP_036016085.1  beta-1,3-galactosyltransferase 5 isoform X1

    UniProtKB/Swiss-Prot
    Q9JI67
    Conserved Domains (1) summary
    cl21608
    Location:69 → 259
    Galactosyl_T; Galactosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JI67.1 GenPept UniProtKB/Swiss-Prot:Q9JI67

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