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ZRANB2 zinc finger RANBP2-type containing 2 [ Homo sapiens (human) ]

Gene ID: 9406, updated on 5-Mar-2024

Summary

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Official Symbol
ZRANB2provided by HGNC
Official Full Name
zinc finger RANBP2-type containing 2provided by HGNC
Primary source
HGNC:HGNC:13058
See related
Ensembl:ENSG00000132485 MIM:604347; AllianceGenome:HGNC:13058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIS; ZIS1; ZIS2; ZNF265
Summary
Enables RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 47.3), lymph node (RPKM 37.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p31.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (71063291..71081035, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (70941292..70959042, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (71528974..71546718, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71172243-71172742 Neighboring gene MPRA-validated peak284 silencer Neighboring gene long intergenic non-protein coding RNA 1788 Neighboring gene uncharacterized LOC102724572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71429249-71429748 Neighboring gene prostaglandin E receptor 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:71512913-71513496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1198 Neighboring gene ZRANB2 antisense RNA 1 Neighboring gene uncharacterized LOC105378795 Neighboring gene ZRANB2 divergent transcript Neighboring gene microRNA 186 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:71927989-71928559 Neighboring gene neuronal growth regulator 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:72203394-72203980 Neighboring gene NEGR1 intronic transcript 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome. Yang YH, et al. Mol Biol Rep, 2013 Sep. PMID 23666063
  2. Crystallization of a ZRANB2-RNA complex. Loughlin FE, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Dec 1. PMID 19052380, Free PMC Article
  3. The structure of the zinc finger domain from human splicing factor ZNF265 fold. Plambeck CA, et al. J Biol Chem, 2003 Jun 20. PMID 12657633
  4. Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene. Nakano M, et al. Gene, 1998 Dec 28. PMID 9931435
  5. ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin. Tanaka I, et al. Nucleic Acids Res, 2020 Mar 18. PMID 31943118, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data identify Aletrnative splicing programs controlled by ZRANB2 and SYF2 and converging on ECT2, that participate to breast cancer cell resistance to doxorubicin.
    Title: ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin.
  2. ZRANB2 is part of the supraspliceosome and causes differential splicing of numerous primary transcripts, some of which might have a role in cancer.
    Title: ZRANB2 localizes to supraspliceosomes and influences the alternative splicing of multiple genes in the transcriptome.
  3. Crystallization of a ZRANB2-RNA complex
    Title: Crystallization of a ZRANB2-RNA complex.
  4. sites responsible for MRNA binding have been characterized.
    Title: The structure of the zinc finger domain from human splicing factor ZNF265 fold.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41119, DKFZp686J1831, DKFZp686N09117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
zinc finger Ran-binding domain-containing protein 2
Names
zinc finger protein 265
zinc finger, RAN-binding domain containing 2
zinc-finger, splicing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005455.5 → NP_005446.2  zinc finger Ran-binding domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_005446.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, which results in an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL136945, AL512443, BC039814, BU677906, DA523601
    Consensus CDS
    CCDS660.1
    UniProtKB/Swiss-Prot
    O95218
    Related
    ENSP00000254821.6, ENST00000254821.10
    Conserved Domains (2) summary
    smart00547
    Location:67 → 91
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:13 → 34
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

  2. NM_203350.3 → NP_976225.1  zinc finger Ran-binding domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_976225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AF065391, AL512443, BC033648, BU677906, DA523601
    Consensus CDS
    CCDS659.1
    UniProtKB/Swiss-Prot
    D3DQ75, O95218, Q53GS3, Q59F92, Q5VV33, Q5VV34, Q8IXN6, Q9UP63
    Related
    ENSP00000359958.3, ENST00000370920.8
    Conserved Domains (2) summary
    smart00547
    Location:67 → 91
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:13 → 34
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    71063291..71081035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434733.1 → XP_047290689.1  zinc finger Ran-binding domain-containing protein 2 isoform X1

    Related
    ENSP00000482026.1, ENST00000611683.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    70941292..70959042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339678.1 → XP_054195653.1  zinc finger Ran-binding domain-containing protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95218.2 GenPept UniProtKB/Swiss-Prot:O95218

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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