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Trim16 tripartite motif-containing 16 [ Mus musculus (house mouse) ]

Gene ID: 94092, updated on 28-Oct-2024

Summary

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Official Symbol
Trim16provided by MGI
Official Full Name
tripartite motif-containing 16provided by MGI
Primary source
MGI:MGI:2137356
See related
Ensembl:ENSMUSG00000047821 AllianceGenome:MGI:2137356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EBBP; 9130006M08Rik
Summary
Predicted to enable DNA binding activity; NACHT domain binding activity; and interleukin-1 binding activity. Located in cytoplasm. Is expressed in central nervous system and genitourinary system. Orthologous to several human genes including TRIM16 (tripartite motif containing 16). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in colon adult (RPKM 13.4), lung adult (RPKM 10.4) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Trim16 in Genome Data Viewer
Location:
11 B2; 11 38.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62711034..62733774)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62820198..62842948)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 286 Neighboring gene zinc finger protein 286, opposite strand Neighboring gene predicted gene, 24151 Neighboring gene STARR-seq mESC enhancer starr_29718 Neighboring gene F-box and WD-40 domain protein 10 Neighboring gene STARR-seq mESC enhancer starr_29719 Neighboring gene STARR-positive B cell enhancer ABC_E1826 Neighboring gene trans-golgi network vesicle protein 23B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy. Liu J, et al. Circ Res, 2022 May 13. PMID 35437018
  2. Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1. Wang L, et al. Cell Metab, 2021 Jul 6. PMID 34146477
  3. TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1. Ren X, et al. Exp Cell Res, 2020 Jun 1. PMID 32251645
  4. Heterozygous loss of keratinocyte TRIM16 expression increases melanocytic cell lesions and lymph node metastasis. Sutton SK, et al. J Cancer Res Clin Oncol, 2019 Sep. PMID 31342168, Free PMC Article
  5. TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling. Shi M, et al. Biochem Biophys Res Commun, 2022 Dec 3. PMID 36208489

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling.
    Title: TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling.
  2. The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy.
    Title: The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy.
  3. Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.
    Title: Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.
  4. TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.
    Title: TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.
  5. TRIM16 expression in keratinocytes is involved in cross talk between keratinocytes and melanocytes, and has a role in melanoma tumorigenesis.
    Title: Heterozygous loss of keratinocyte TRIM16 expression increases melanocytic cell lesions and lymph node metastasis.
  6. we demonstrate that genetic variation in Trim16 leads to its strain-dependent expression, which alters susceptibility to bleomycin-induced pulmonary fibrosis in mice.
    Title: Positional cloning reveals strain-dependent expression of Trim16 to alter susceptibility to bleomycin-induced pulmonary fibrosis in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables NACHT domain binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-1 binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 16
Names
E3 ubiquitin-protein ligase TRIM16
estrogen-responsive B box protein
tripartite motif protein 16
NP_444399.2
XP_006534643.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053169.2 → NP_444399.2  tripartite motif-containing protein 16

    See identical proteins and their annotated locations for NP_444399.2

    Status: VALIDATED

    Source sequence(s)
    AK053139, AK087112, BB033733
    Consensus CDS
    CCDS24832.1
    UniProtKB/Swiss-Prot
    Q7TPY6, Q8C332, Q8C6V0, Q99PP9
    UniProtKB/TrEMBL
    Q5SVT2
    Related
    ENSMUSP00000055542.6, ENSMUST00000055006.12
    Conserved Domains (2) summary
    pfam00643
    Location:117 → 157
    zf-B_box; B-box zinc finger
    cd12890
    Location:357 → 538
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62711034..62733774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534580.5 → XP_006534643.1  tripartite motif-containing protein 16 isoform X1

    UniProtKB/Swiss-Prot
    Q7TPY6, Q8C332, Q8C6V0, Q99PP9
    Related
    ENSMUSP00000104343.2, ENSMUST00000108703.2
    Conserved Domains (4) summary
    pfam05483
    Location:87 → 275
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd12890
    Location:270 → 451
    SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
    cd19769
    Location:33 → 78
    Bbox2_TRIM16-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM16, TRIM29, TRIM47 and similar proteins
    cl00034
    Location:1 → 26
    Bbox_SF; B-box-type zinc finger superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PP9.2 GenPept UniProtKB/Swiss-Prot:Q99PP9

Gene LinkOut

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