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Med15 mediator complex subunit 15 [ Mus musculus (house mouse) ]

Gene ID: 94112, updated on 2-Nov-2024

Summary

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Official Symbol
Med15provided by MGI
Official Full Name
mediator complex subunit 15provided by MGI
Primary source
MGI:MGI:2137379
See related
Ensembl:ENSMUSG00000012114 AllianceGenome:MGI:2137379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcqap; mPcqap; A230074L19Rik
Summary
Predicted to enable transcription coregulator activity. Acts upstream of or within somatic stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of core mediator complex. Is expressed in several structures, including branchial arch; central nervous system; facial prominence; limb; and limb bud. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MED15 (mediator complex subunit 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 37.3), small intestine adult (RPKM 28.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Med15 in Genome Data Viewer
Location:
16 A3; 16 10.94 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17469072..17540811, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17651208..17722947, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17619324-17619507 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene STARR-seq mESC enhancer starr_40259 Neighboring gene coiled-coil domain containing 74A Neighboring gene calcyclin binding protein pseudogene Neighboring gene ribosomal protein L26, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E5529 Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene copy 8 Neighboring gene biorientation of chromosomes in cell division 1, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit. Berti L, et al. Genomics, 2001 Jun 15. PMID 11414760
  2. Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. Tan C, et al. PLoS Genet, 2021 Sep. PMID 34506481, Free PMC Article
  3. A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Maynard TM, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14614146, Free PMC Article
  4. Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Kolonay DW, et al. Front Cell Dev Biol, 2024. PMID 38690566, Free PMC Article
  5. Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration. Li X, et al. Life Sci, 2023 May 1. PMID 36878279

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 15
Names
PC2 glutamine/Q-rich-associated protein
positive cofactor 2 glutamine/Q-rich-associated protein
positive cofactor 2, multiprotein complex, glutamine/Q-rich-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040683.2 → NP_001035773.1  mediator of RNA polymerase II transcription subunit 15 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC087802, AC115733, AK131186
    Consensus CDS
    CCDS37273.1
    UniProtKB/TrEMBL
    E9Q7C1, Q6KAM1
    Related
    ENSMUSP00000079737.7, ENSMUST00000080936.14
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 745
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  2. NM_001285884.1 → NP_001272813.1  mediator of RNA polymerase II transcription subunit 15 isoform c

    See identical proteins and their annotated locations for NP_001272813.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC087802, AC115733
    Consensus CDS
    CCDS88892.1
    UniProtKB/TrEMBL
    Q3TE00, Q6KAM1
    Related
    ENSMUSP00000156291.2, ENSMUST00000232236.2
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 762
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  3. NM_001285886.1 → NP_001272815.1  mediator of RNA polymerase II transcription subunit 15 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences. These differences result in the use of a alternate start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC087802, AC115733
    Consensus CDS
    CCDS88891.1
    UniProtKB/TrEMBL
    A0A338P730, Q3TLG6
    Related
    ENSMUSP00000156242.2, ENSMUST00000232645.2
    Conserved Domains (1) summary
    pfam09606
    Location:259 → 635
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  4. NM_001358404.1 → NP_001345333.1  mediator of RNA polymerase II transcription subunit 15 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform e, which is shorter than isoform a.
    Source sequence(s)
    AC087802, AC115733
    UniProtKB/TrEMBL
    Q6KAM1
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 714
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  5. NM_033609.3 → NP_291087.2  mediator of RNA polymerase II transcription subunit 15 isoform a

    See identical proteins and their annotated locations for NP_291087.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC087802, AC115733, AK142224
    Consensus CDS
    CCDS37274.1
    UniProtKB/Swiss-Prot
    G3X8S4, Q924H2
    UniProtKB/TrEMBL
    Q6KAM1
    Related
    ENSMUSP00000012259.8, ENSMUST00000012259.9
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 785
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17469072..17540811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317174.2 → XP_017172663.1  mediator of RNA polymerase II transcription subunit 15 isoform X7

    UniProtKB/TrEMBL
    Q6KAM1
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 702
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  2. XM_017317173.2 → XP_017172662.1  mediator of RNA polymerase II transcription subunit 15 isoform X4

    UniProtKB/TrEMBL
    Q6KAM1
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 742
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  3. XM_006522783.4 → XP_006522846.1  mediator of RNA polymerase II transcription subunit 15 isoform X11

    UniProtKB/TrEMBL
    Q6KAM1
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 674
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  4. XM_017317172.3 → XP_017172661.1  mediator of RNA polymerase II transcription subunit 15 isoform X2

    UniProtKB/TrEMBL
    Q6KAM1
    Conserved Domains (1) summary
    pfam09606
    Location:17 → 775
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  5. XM_017317175.2 → XP_017172664.1  mediator of RNA polymerase II transcription subunit 15 isoform X13

    UniProtKB/TrEMBL
    Q3TLG6
    Conserved Domains (1) summary
    pfam09606
    Location:343 → 631
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  6. XM_036160194.1 → XP_036016087.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

    UniProtKB/TrEMBL
    Q80UN2
    Conserved Domains (1) summary
    pfam09606
    Location:416 → 704
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  7. XM_036160198.1 → XP_036016091.1  mediator of RNA polymerase II transcription subunit 15 isoform X14

    UniProtKB/TrEMBL
    Q80UN2
    Conserved Domains (1) summary
    pfam09606
    Location:296 → 584
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  8. XM_030249350.2 → XP_030105210.1  mediator of RNA polymerase II transcription subunit 15 isoform X10

    UniProtKB/TrEMBL
    Q6KAM1
    Conserved Domains (1) summary
    pfam09606
    Location:1 → 676
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  9. XM_006522779.5 → XP_006522842.1  mediator of RNA polymerase II transcription subunit 15 isoform X3

    UniProtKB/TrEMBL
    Q6KAM1
    Conserved Domains (1) summary
    pfam09606
    Location:1 → 759
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  10. XM_036160195.1 → XP_036016088.1  mediator of RNA polymerase II transcription subunit 15 isoform X6

    UniProtKB/TrEMBL
    Q80UN2
    Conserved Domains (1) summary
    pfam09606
    Location:416 → 704
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  11. XM_036160197.1 → XP_036016090.1  mediator of RNA polymerase II transcription subunit 15 isoform X12

    UniProtKB/TrEMBL
    Q3TLG6
    Conserved Domains (1) summary
    pfam09606
    Location:360 → 648
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  12. XM_030249349.2 → XP_030105209.1  mediator of RNA polymerase II transcription subunit 15 isoform X9

    UniProtKB/TrEMBL
    Q3TLG6
    Conserved Domains (1) summary
    pfam09606
    Location:1 → 688
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  13. XM_030249346.2 → XP_030105206.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

    UniProtKB/TrEMBL
    Q6KAM1
    Conserved Domains (1) summary
    pfam09606
    Location:23 → 784
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  14. XM_030249348.2 → XP_030105208.1  mediator of RNA polymerase II transcription subunit 15 isoform X5

    UniProtKB/TrEMBL
    Q3TLG6
    Conserved Domains (1) summary
    pfam09606
    Location:23 → 713
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  15. XM_036160196.1 → XP_036016089.1  mediator of RNA polymerase II transcription subunit 15 isoform X8

    UniProtKB/TrEMBL
    Q6KAM1
    Conserved Domains (1) summary
    pfam09606
    Location:23 → 701
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RNA

  1. XR_004939258.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924H2.3 GenPept UniProtKB/Swiss-Prot:Q924H2

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