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TJP2 tight junction protein 2 [ Homo sapiens (human) ]

Gene ID: 9414, updated on 3-Nov-2024

Summary

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Official Symbol
TJP2provided by HGNC
Official Full Name
tight junction protein 2provided by HGNC
Primary source
HGNC:HGNC:11828
See related
Ensembl:ENSG00000119139 MIM:607709; AllianceGenome:HGNC:11828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZO2; X104; FHCA1; PFIC4; DFNA51; DUP9q21.11; C9DUPq21.11
Summary
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in lung (RPKM 15.3), fat (RPKM 14.2) and 25 other tissues See more
Orthologs
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Genomic context

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See TJP2 in Genome Data Viewer
Location:
9q21.11
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (69121264..69255208)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (81294639..81423094)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (71736180..71870124)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr9.764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28445 Neighboring gene Sharpr-MPRA regulatory region 187 Neighboring gene Friedreich ataxia repeat instability region Neighboring gene protein kinase cAMP-activated catalytic subunit gamma Neighboring gene Sharpr-MPRA regulatory region 4997 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:71660286-71661281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71669749-71670250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71670251-71670750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:71681521-71682120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:71683371-71683870 Neighboring gene frataxin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:71703383-71703883 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:71705161-71706130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71731558-71732058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71732059-71732559 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:71735458-71736416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:71745576-71746105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28446 Neighboring gene uncharacterized LOC124902175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28447 Neighboring gene Sharpr-MPRA regulatory region 4978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71856696-71857196 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71857197-71857697 Neighboring gene uncharacterized LOC124902176 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:71897736-71898504 Neighboring gene NANOG hESC enhancer GRCh37_chr9:71898508-71899009 Neighboring gene Sharpr-MPRA regulatory region 15637 Neighboring gene BRAF-activated non-protein coding RNA Neighboring gene endosomal transmembrane epsin interactor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma. Chlenski A, et al. Int J Cancer, 1999 Jul 2. PMID 10360833
  2. Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma. Li T, et al. Exp Ther Med, 2017 Oct. PMID 29042928, Free PMC Article
  3. Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues. Chlenski A, et al. Biochim Biophys Acta, 2000 Oct 2. PMID 11018256
  4. ZO-2, a tight junction protein involved in gene expression, proliferation, apoptosis, and cell size regulation. González-Mariscal L, et al. Ann N Y Acad Sci, 2017 Jun. PMID 28415133
  5. Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2. Glaunsinger BA, et al. EMBO J, 2001 Oct 15. PMID 11598001, Free PMC Article

See all (189) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP.
    Title: p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP.
  2. Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD.
    Title: Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD.
  3. TJP2 hepatobiliary disorders: Novel variants and clinical diversity.
    Title: TJP2 hepatobiliary disorders: Novel variants and clinical diversity.
  4. New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report.
    Title: New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report.
  5. Supra-molecular assembly and positioning of tight junctions as continuous networks of adhesion strands are dependent on the membrane-associated scaffolding proteins ZO1 and ZO2.
    Title: Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions.
  6. It is a potential target of miR-543.
    Title: miR-543 promoted the cell proliferation and invasion of nasopharyngeal carcinoma by targeting the JAM-A.
  7. Results suggested that a reduction in CLDN18-dependent ZO-2 expression enhances MMP2 expression in lung adenocarcinoma cells, resulting in the promotion of the cell migration.
    Title: ZO-2 Suppresses Cell Migration Mediated by a Reduction in Matrix Metalloproteinase 2 in Claudin-18-Expressing Lung Adenocarcinoma A549 Cells.
  8. Mutations in the genes responsible for PFIC may be involved in both young and adults with cryptogenic cholestasis in a considerable number of cases, including in heterozygous status.
    Title: Cryptogenic cholestasis in young and adults: ATP8B1, ABCB11, ABCB4, and TJP2 gene variants analysis by high-throughput sequencing.
  9. Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS
    Title: Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse.
  10. A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39
    Title: Genetic profiling of children with advanced cholestatic liver disease.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cholestasis, progressive familial intrahepatic, 4
MedGen: C2931067 OMIM: 615878 GeneReviews: Not available
not available
Hypercholanemia, familial 1
MedGen: C5542604 OMIM: 607748 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
EBI GWAS Catalog
Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Treatment of cultured human brain endothelial cells with HIV-1 gp120 results in increased permeability of the endothelial monolayer and causes disruption and downregulation of the tight junction proteins ZO-1, ZO-2, and occludin in these cells PubMed
Tat tat Exposure of brain micro vascular endothelial cells to HIV-1 Tat results in a decrease of claudin-1, claudin-5, and zonula occludens-2 expression and cellular redistribution of claudin-5, suggesting potential disturbance of the blood-brain barrier by Tat PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26306

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of endothelial intestinal barrier IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intestinal absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of blood-brain barrier NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of blood-brain barrier permeability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane permeability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tight junction protein ZO-2
Names
Friedreich ataxia region gene X104 (tight junction protein ZO-2)
zona occludens 2
zonula occludens protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016342.2 RefSeqGene

    Range
    78371..159302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1201

mRNA and Protein(s)

  1. NM_001170414.2 → NP_001163885.1  tight junction protein ZO-2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences include a distinct 5' UTR and translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AA724570, AI738923, AK295016, CX865985, DA270962, DB196171
    UniProtKB/TrEMBL
    B7Z2R3
    Related
    ENSP00000496877.1, ENST00000647986.1
    Conserved Domains (5) summary
    cd12027
    Location:581 → 643
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:677 → 856
    GuKc; Guanylate kinase homologues
    COG0265
    Location:279 → 369
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:276 → 359
    PDZ; PDZ domain (Also known as DHR or GLGF)

  2. NM_001170415.1 → NP_001163886.1  tight junction protein ZO-2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences include a distinct 5' UTR and translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK302483, AL358113, DC325189
    Consensus CDS
    CCDS55315.1
    UniProtKB/TrEMBL
    A0A3B3ITE1
    Related
    ENSP00000442090.1, ENST00000535702.6
    Conserved Domains (5) summary
    cd12027
    Location:608 → 670
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:704 → 883
    GuKc; Guanylate kinase homologues
    COG0265
    Location:306 → 396
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:303 → 386
    PDZ; PDZ domain (Also known as DHR or GLGF)

  3. NM_001170416.2 → NP_001163887.1  tight junction protein ZO-2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AL358113
    Consensus CDS
    CCDS55316.1
    UniProtKB/TrEMBL
    A0A3B3ITE1
    Related
    ENSP00000438262.1, ENST00000539225.2
    Conserved Domains (5) summary
    cd12027
    Location:635 → 697
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:731 → 910
    GuKc; Guanylate kinase homologues
    COG0265
    Location:333 → 423
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:63 → 148
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:330 → 413
    PDZ; PDZ domain (Also known as DHR or GLGF)

  4. NM_001369870.1 → NP_001356799.1  tight junction protein ZO-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL162730, AL358113, AL590238
    UniProtKB/TrEMBL
    A0A3B3ITE1
    Conserved Domains (6) summary
    cd12027
    Location:579 → 641
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:675 → 854
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:160 → 251
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:121 → 203
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:276 → 359
    PDZ; PDZ domain (Also known as DHR or GLGF)

  5. NM_001369871.1 → NP_001356800.1  tight junction protein ZO-2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL358113, AL590238
    UniProtKB/TrEMBL
    A0A3B3ITE1
    Conserved Domains (6) summary
    cd12027
    Location:581 → 643
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:677 → 856
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:160 → 251
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:121 → 203
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:276 → 359
    PDZ; PDZ domain (Also known as DHR or GLGF)

  6. NM_001369872.1 → NP_001356801.1  tight junction protein ZO-2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL358113
    UniProtKB/TrEMBL
    A0A3B3ISZ5
    Related
    ENSP00000497539.1, ENST00000649943.1
    Conserved Domains (6) summary
    cd12027
    Location:604 → 666
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:700 → 879
    GuKc; Guanylate kinase homologues
    smart00228
    Location:303 → 385
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:183 → 274
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:144 → 226
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

  7. NM_001369873.1 → NP_001356802.1  tight junction protein ZO-2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL358113
    UniProtKB/TrEMBL
    B7Z954
    Conserved Domains (6) summary
    cd12027
    Location:604 → 666
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:700 → 879
    GuKc; Guanylate kinase homologues
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:183 → 274
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:144 → 226
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:299 → 382
    PDZ; PDZ domain (Also known as DHR or GLGF)

  8. NM_001369874.1 → NP_001356803.1  tight junction protein ZO-2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL358113
    Consensus CDS
    CCDS94416.1
    UniProtKB/TrEMBL
    A0A3B3IU51, B7Z2R3
    Related
    ENSP00000498068.1, ENST00000649134.1
    Conserved Domains (6) summary
    cd12027
    Location:608 → 670
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:704 → 883
    GuKc; Guanylate kinase homologues
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:187 → 278
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:148 → 230
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:303 → 386
    PDZ; PDZ domain (Also known as DHR or GLGF)

  9. NM_001369875.1 → NP_001356804.1  tight junction protein ZO-2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL358113
    UniProtKB/TrEMBL
    A0A3B3ITE1
    Related
    ENSP00000497861.1, ENST00000650084.1
    Conserved Domains (6) summary
    cd12027
    Location:608 → 670
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:704 → 883
    GuKc; Guanylate kinase homologues
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:187 → 278
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:148 → 230
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:303 → 386
    PDZ; PDZ domain (Also known as DHR or GLGF)

  10. NM_004817.4 → NP_004808.2  tight junction protein ZO-2 isoform 1

    See identical proteins and their annotated locations for NP_004808.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AL358113, BC027592, DB090695, L27476
    Consensus CDS
    CCDS6627.1
    UniProtKB/Swiss-Prot
    A2A3H9, B7Z2R8, B7Z7T6, F5H301, F5H886, Q15883, Q5VXL0, Q5VXL1, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1, Q9UDY2
    UniProtKB/TrEMBL
    A0A3B3ITE1
    Related
    ENSP00000366453.4, ENST00000377245.9
    Conserved Domains (5) summary
    cd12027
    Location:604 → 666
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:700 → 879
    GuKc; Guanylate kinase homologues
    COG0265
    Location:302 → 392
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:299 → 382
    PDZ; PDZ domain (Also known as DHR or GLGF)

  11. NM_201629.3 → NP_963923.1  tight junction protein ZO-2 isoform 2

    See identical proteins and their annotated locations for NP_963923.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the 3' coding region, compared to variant (1). The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA724570, AK295016, AK304447, AL358113, DB090695
    Consensus CDS
    CCDS6628.1
    UniProtKB/TrEMBL
    B7Z2R3
    Related
    ENSP00000345893.4, ENST00000348208.9
    Conserved Domains (5) summary
    cd12027
    Location:604 → 666
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:700 → 879
    GuKc; Guanylate kinase homologues
    COG0265
    Location:302 → 392
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:299 → 382
    PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    69121264..69255208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519206.3 → XP_011517508.1  tight junction protein ZO-2 isoform X1

    See identical proteins and their annotated locations for XP_011517508.1

    UniProtKB/TrEMBL
    A0A3B3ITE1
    Conserved Domains (6) summary
    cd12027
    Location:581 → 643
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:677 → 856
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:160 → 251
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:121 → 203
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:276 → 359
    PDZ; PDZ domain (Also known as DHR or GLGF)

  2. XM_011519208.3 → XP_011517510.1  tight junction protein ZO-2 isoform X1

    See identical proteins and their annotated locations for XP_011517510.1

    UniProtKB/TrEMBL
    A0A3B3ITE1
    Conserved Domains (6) summary
    cd12027
    Location:581 → 643
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:677 → 856
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:160 → 251
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:121 → 203
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:276 → 359
    PDZ; PDZ domain (Also known as DHR or GLGF)

  3. XM_047424090.1 → XP_047280046.1  tight junction protein ZO-2 isoform X1

  4. XM_047424095.1 → XP_047280051.1  tight junction protein ZO-2 isoform X2

  5. XM_047424091.1 → XP_047280047.1  tight junction protein ZO-2 isoform X1

  6. XM_011519207.3 → XP_011517509.1  tight junction protein ZO-2 isoform X1

    See identical proteins and their annotated locations for XP_011517509.1

    UniProtKB/TrEMBL
    A0A3B3ITE1
    Related
    ENSP00000489860.1, ENST00000636438.1
    Conserved Domains (6) summary
    cd12027
    Location:581 → 643
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:677 → 856
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:160 → 251
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:121 → 203
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:276 → 359
    PDZ; PDZ domain (Also known as DHR or GLGF)

  7. XM_047424092.1 → XP_047280048.1  tight junction protein ZO-2 isoform X1

  8. XM_011519209.3 → XP_011517511.1  tight junction protein ZO-2 isoform X1

    See identical proteins and their annotated locations for XP_011517511.1

    UniProtKB/TrEMBL
    A0A3B3ITE1
    Conserved Domains (6) summary
    cd12027
    Location:581 → 643
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:677 → 856
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:160 → 251
    SF-CC1; splicing factor, CC1-like family
    TIGR01642
    Location:121 → 203
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    pfam00595
    Location:276 → 359
    PDZ; PDZ domain (Also known as DHR or GLGF)

  9. XM_047424094.1 → XP_047280050.1  tight junction protein ZO-2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    81294639..81423094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364197.1 → XP_054220172.1  tight junction protein ZO-2 isoform X1

  2. XM_054364195.1 → XP_054220170.1  tight junction protein ZO-2 isoform X1

  3. XM_054364196.1 → XP_054220171.1  tight junction protein ZO-2 isoform X1

  4. XM_054364202.1 → XP_054220177.1  tight junction protein ZO-2 isoform X2

  5. XM_054364194.1 → XP_054220169.1  tight junction protein ZO-2 isoform X1

  6. XM_054364198.1 → XP_054220173.1  tight junction protein ZO-2 isoform X1

  7. XM_054364200.1 → XP_054220175.1  tight junction protein ZO-2 isoform X1

  8. XM_054364199.1 → XP_054220174.1  tight junction protein ZO-2 isoform X1

  9. XM_054364201.1 → XP_054220176.1  tight junction protein ZO-2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001170630.1: Suppressed sequence

    Description
    NM_001170630.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UDY2.2 GenPept UniProtKB/Swiss-Prot:Q9UDY2

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