Slc27a1 solute carrier family 27 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc27a1provided by RGD
Official Full Name: solute carrier family 27 member 1provided by RGD
Primary source: RGD:620927
See related: EnsemblRapid:ENSRNOG00000018170 AllianceGenome:RGD:620927
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FATP; FATP-1
Summary: Predicted to enable several functions, including fatty acid-CoA ligase activity; monocarboxylic acid transmembrane transporter activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including glycerophospholipid biosynthetic process; monocarboxylic acid transport; and regulation of lipid biosynthetic process. Predicted to act upstream of or within several processes, including adiponectin-activated signaling pathway; positive regulation of heat generation; and response to insulin. Located in caveola and mitochondrial inner membrane. Biomarker of familial hyperlipidemia; glucose intolerance; hyperinsulinism; myocardial infarction; and obesity. Orthologous to human SLC27A1 (solute carrier family 27 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 168.8), Heart (RPKM 85.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18311859..18337024)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18278984..18300173)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (19997823..20016193)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Fatp1 in skeletal muscle increased the rate of long-chain fatty acid transport and channelled these lipids to oxidation, not to intramuscular lipid accumulation.
Title: Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc27a1 (e-PCR), detects polymorphism
- UniSTS:507227

RH127318 (e-PCR)
- UniSTS:210628

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables biotin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables biotin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fatty acid transmembrane transporter activity	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oleate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables oleoyl-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oleoyl-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables oleoyl-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables very long-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables very long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in biotin import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in biotin import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in biotin transport	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in glucose import in response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in glucose import in response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid transport across blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid import into cell	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-chain fatty acid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within medium-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylserine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heat generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of heat generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cold	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cold	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: long-chain fatty acid transport protein 1

Names: arachidonate--CoA ligase; fatty acid transport protein 1; long-chain-fatty-acid--CoA ligase; solute carrier family 27 (fatty acid transporter), member 1; very long-chain acyl-CoA synthetase

NP_446032.2

EC 6.2.1.15

EC 6.2.1.3

XP_006253015.1

EC 6.2.1.15

EC 6.2.1.3

XP_006253016.1

EC 6.2.1.15

EC 6.2.1.3

XP_008769378.3

EC 6.2.1.15

EC 6.2.1.3

XP_038950805.2

EC 6.2.1.15

EC 6.2.1.3

XP_063131863.1

EC 6.2.1.15

EC 6.2.1.3

XP_063131864.1

EC 6.2.1.15

EC 6.2.1.3

XP_063131865.1

EC 6.2.1.15

EC 6.2.1.3

XP_063131866.1

EC 6.2.1.15

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428638.1 → NP_001415567.1 long-chain fatty acid transport protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

F7EPC1, Q6GMM8
NM_001428639.1 → NP_001415568.1 long-chain fatty acid transport protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

F7EPC1, Q6GMM8
NM_053580.3 → NP_446032.2 long-chain fatty acid transport protein 1

See identical proteins and their annotated locations for NP_446032.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

P97849

UniProtKB/TrEMBL

F7EPC1, Q6GMM8

Related

ENSRNOP00000077487.2, ENSRNOT00000095535.2

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

18311859..18337024

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275796.1 → XP_063131866.1 long-chain fatty acid transport protein 1 isoform X3

UniProtKB/TrEMBL

F7EPC1, Q6GMM8
XM_063275795.1 → XP_063131865.1 long-chain fatty acid transport protein 1 isoform X3

UniProtKB/TrEMBL

F7EPC1, Q6GMM8
XM_006252954.2 → XP_006253016.1 long-chain fatty acid transport protein 1 isoform X3

Conserved Domains (1) summary

cl17068
Location:104 → 611

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_006252953.5 → XP_006253015.1 long-chain fatty acid transport protein 1 isoform X2

UniProtKB/Swiss-Prot

P97849

UniProtKB/TrEMBL

A0A8I5YCE2

Related

ENSRNOP00000083160.2, ENSRNOT00000101879.2

Conserved Domains (2) summary

PRK08279
Location:45 → 649

PRK08279; long-chain-acyl-CoA synthetase; Validated

cl17068
Location:107 → 614

AFD_class_I; Adenylate forming domain, Class I superfamily
XM_063275793.1 → XP_063131863.1 long-chain fatty acid transport protein 1 isoform X1

Related

ENSRNOP00000024659.4, ENSRNOT00000024659.6
XM_008771156.4 → XP_008769378.3 long-chain fatty acid transport protein 1 isoform X1
XM_063275794.1 → XP_063131864.1 long-chain fatty acid transport protein 1 isoform X1
XM_039094877.2 → XP_038950805.2 long-chain fatty acid transport protein 1 isoform X1