U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Madd MAP-kinase activating death domain [ Rattus norvegicus (Norway rat) ]

Gene ID: 94193, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Maddprovided by RGD
Official Full Name
MAP-kinase activating death domainprovided by RGD
Primary source
RGD:619922
See related
EnsemblRapid:ENSRNOG00000012568 AllianceGenome:RGD:619922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RabGEF; RabGEP
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of growth hormone secretion and negative regulation of pancreatic amylase secretion. Located in synaptic vesicle. Is active in synapse. Biomarker of transient cerebral ischemia. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 155.6), Spleen (RPKM 101.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Madd in Genome Data Viewer
Location:
3q24
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97570141..97613688, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77114330..77157865, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (79960301..80003023, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101909 Neighboring gene Spi-1 proto-oncogene Neighboring gene myosin binding protein C3 Neighboring gene transfer RNA alanine (anticodon AGC) 34 Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel function of the C-terminal lipid moieties of Rab3A small G protein implicated in Ca2+-dependent exocytosis--inhibition of interaction with GTP and reduction of this inhibition by phospholipid. Jin-no Y, et al. Genes Cells, 1997 Apr. PMID 9224661
  2. Purification and properties of Rab3 GEP (DENN/MADD). Sakisaka T, et al. Methods Enzymol, 2005. PMID 16473592
  3. The onset of apoptosis of neurons induced by ischemia-reperfusion injury is delayed by transient period of hypertension in rats. Smrcka M, et al. Physiol Res, 2003. PMID 12625816
  4. DENN, a novel human gene differentially expressed in normal and neoplastic cells. Chow VT, et al. DNA Seq, 1996. PMID 8988362
  5. Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins. Wada M, et al. J Biol Chem, 1997 Feb 14. PMID 9020086

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings indicated that Madd functions as a guanine nucleotide exchange factor for Rab27 in parotid acinar cells and regulates isoproterenol-stimulated amylase release.
    Title: MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterograde synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of growth hormone secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of pancreatic amylase secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rab protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
MAP kinase-activating death domain protein
Names
Rab3 GDP/GTP exchange protein
rab3 GDP/GTP exchange factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429606.1 → NP_001416535.1  MAP kinase-activating death domain protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6A7E5

  2. NM_001429607.1 → NP_001416536.1  MAP kinase-activating death domain protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZSL5

  3. NM_001429608.1 → NP_001416537.1  MAP kinase-activating death domain protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_001429609.1 → NP_001416538.1  MAP kinase-activating death domain protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  5. NM_001429610.1 → NP_001416539.1  MAP kinase-activating death domain protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  6. NM_001429611.1 → NP_001416540.1  MAP kinase-activating death domain protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  7. NM_001429612.1 → NP_001416541.1  MAP kinase-activating death domain protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  8. NM_001429613.1 → NP_001416542.1  MAP kinase-activating death domain protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2KA27

  9. NM_001429614.1 → NP_001416543.1  MAP kinase-activating death domain protein isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  10. NM_053585.3 → NP_446037.1  MAP kinase-activating death domain protein isoform 1

    See identical proteins and their annotated locations for NP_446037.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    O08873
    UniProtKB/TrEMBL
    A0A8L2Q8M9, A6HNA9
    Related
    ENSRNOP00000017360.5, ENSRNOT00000017360.8
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    97570141..97613688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284778.1 → XP_063140848.1  MAP kinase-activating death domain protein isoform X32

  2. XM_063284754.1 → XP_063140824.1  MAP kinase-activating death domain protein isoform X2

  3. XM_063284759.1 → XP_063140829.1  MAP kinase-activating death domain protein isoform X7

  4. XM_063284757.1 → XP_063140827.1  MAP kinase-activating death domain protein isoform X5

  5. XM_063284765.1 → XP_063140835.1  MAP kinase-activating death domain protein isoform X13

  6. XM_063284755.1 → XP_063140825.1  MAP kinase-activating death domain protein isoform X3

  7. XM_063284751.1 → XP_063140821.1  MAP kinase-activating death domain protein isoform X1

  8. XM_063284764.1 → XP_063140834.1  MAP kinase-activating death domain protein isoform X12

  9. XM_063284758.1 → XP_063140828.1  MAP kinase-activating death domain protein isoform X6

  10. XM_063284762.1 → XP_063140832.1  MAP kinase-activating death domain protein isoform X10

  11. XM_063284767.1 → XP_063140837.1  MAP kinase-activating death domain protein isoform X16

  12. XM_063284756.1 → XP_063140826.1  MAP kinase-activating death domain protein isoform X4

  13. XM_063284760.1 → XP_063140830.1  MAP kinase-activating death domain protein isoform X8

  14. XM_063284776.1 → XP_063140846.1  MAP kinase-activating death domain protein isoform X28

    Related
    ENSRNOP00000087537.2, ENSRNOT00000111515.2

  15. XM_063284772.1 → XP_063140842.1  MAP kinase-activating death domain protein isoform X24

  16. XM_063284766.1 → XP_063140836.1  MAP kinase-activating death domain protein isoform X15

  17. XM_063284771.1 → XP_063140841.1  MAP kinase-activating death domain protein isoform X23

  18. XM_039106011.2 → XP_038961939.1  MAP kinase-activating death domain protein isoform X14

    UniProtKB/TrEMBL
    A0A8I5ZTV3
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  19. XM_063284763.1 → XP_063140833.1  MAP kinase-activating death domain protein isoform X11

  20. XM_039106022.2 → XP_038961950.1  MAP kinase-activating death domain protein isoform X22

    UniProtKB/TrEMBL
    A0A8L2Q8M9
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  21. XM_039106019.2 → XP_038961947.1  MAP kinase-activating death domain protein isoform X19

    UniProtKB/TrEMBL
    A0A8L2Q8M9
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  22. XM_039106028.2 → XP_038961956.1  MAP kinase-activating death domain protein isoform X29

    UniProtKB/TrEMBL
    A0A8I5ZTV3
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  23. XM_039106021.2 → XP_038961949.1  MAP kinase-activating death domain protein isoform X21

    UniProtKB/TrEMBL
    A0A8I5ZTV3
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  24. XM_063284770.1 → XP_063140840.1  MAP kinase-activating death domain protein isoform X20

  25. XM_063284761.1 → XP_063140831.1  MAP kinase-activating death domain protein isoform X9

    Related
    ENSRNOP00000075233.2, ENSRNOT00000079394.3

  26. XM_039106031.2 → XP_038961959.1  MAP kinase-activating death domain protein isoform X31

    UniProtKB/TrEMBL
    A0A8L2Q8M9
    Conserved Domains (3) summary
    smart00801
    Location:485 → 553
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:172 → 401
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:7 → 97
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  27. XM_063284777.1 → XP_063140847.1  MAP kinase-activating death domain protein isoform X30

  28. XM_063284773.1 → XP_063140843.1  MAP kinase-activating death domain protein isoform X25

  29. XM_063284775.1 → XP_063140845.1  MAP kinase-activating death domain protein isoform X27

  30. XM_063284793.1 → XP_063140863.1  MAP kinase-activating death domain protein isoform X47

  31. XM_063284774.1 → XP_063140844.1  MAP kinase-activating death domain protein isoform X26

  32. XM_063284768.1 → XP_063140838.1  MAP kinase-activating death domain protein isoform X17

  33. XM_063284753.1 → XP_063140823.1  MAP kinase-activating death domain protein isoform X1

  34. XM_063284752.1 → XP_063140822.1  MAP kinase-activating death domain protein isoform X1

  35. XM_063284769.1 → XP_063140839.1  MAP kinase-activating death domain protein isoform X18

  36. XM_063284792.1 → XP_063140862.1  MAP kinase-activating death domain protein isoform X46

  37. XM_063284781.1 → XP_063140851.1  MAP kinase-activating death domain protein isoform X35

  38. XM_063284780.1 → XP_063140850.1  MAP kinase-activating death domain protein isoform X34

    UniProtKB/TrEMBL
    A0A8I5Y5V9

  39. XM_063284787.1 → XP_063140857.1  MAP kinase-activating death domain protein isoform X41

  40. XM_063284785.1 → XP_063140855.1  MAP kinase-activating death domain protein isoform X39

  41. XM_063284786.1 → XP_063140856.1  MAP kinase-activating death domain protein isoform X40

  42. XM_063284783.1 → XP_063140853.1  MAP kinase-activating death domain protein isoform X37

  43. XM_063284779.1 → XP_063140849.1  MAP kinase-activating death domain protein isoform X33

    Related
    ENSRNOP00000076460.2, ENSRNOT00000111613.2

  44. XM_063284790.1 → XP_063140860.1  MAP kinase-activating death domain protein isoform X44

  45. XM_063284789.1 → XP_063140859.1  MAP kinase-activating death domain protein isoform X43

  46. XM_063284788.1 → XP_063140858.1  MAP kinase-activating death domain protein isoform X42

  47. XM_063284784.1 → XP_063140854.1  MAP kinase-activating death domain protein isoform X38

  48. XM_063284782.1 → XP_063140852.1  MAP kinase-activating death domain protein isoform X36

  49. XM_063284791.1 → XP_063140861.1  MAP kinase-activating death domain protein isoform X45

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08873.1 GenPept UniProtKB/Swiss-Prot:O08873

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous