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Ptprr protein tyrosine phosphatase, receptor type, R [ Rattus norvegicus (Norway rat) ]

Gene ID: 94202, updated on 17-Aug-2024

Summary

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Official Symbol
Ptprrprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Rprovided by RGD
Primary source
RGD:620780
See related
EnsemblRapid:ENSRNOG00000004483 AllianceGenome:RGD:620780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pcptp1; R-PTP-R; PC12-PTP1
Summary
Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Involved in neuron differentiation. Predicted to be located in cell junction; cytosol; and plasma membrane. Orthologous to human PTPRR (protein tyrosine phosphatase receptor type R). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905857.1 and NW_007905858.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]
Expression
Biased expression in Brain (RPKM 85.0), Heart (RPKM 53.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (53548611..53815632)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (51662595..51929605)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (59039717..59325925)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479872 Neighboring gene uncharacterized LOC102551482 Neighboring gene uncharacterized LOC120093592 Neighboring gene TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, pseudogene 1 Neighboring gene uncharacterized LOC120093594 Neighboring gene uncharacterized LOC120093595 Neighboring gene protein tyrosine phosphatase, receptor type, B Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction between chicken protein tyrosine phosphatase 1 (CPTP1)-like rat protein phosphatase 1 (PTP1) and p60(v-src) in v-src-transformed Rat-1 fibroblasts. Jung EJ, et al. Exp Mol Med, 2002 Dec 31. PMID 12526090
  2. A neuronal protein tyrosine phosphatase induced by nerve growth factor. Sharma E, et al. J Biol Chem, 1995 Jan 6. PMID 7814416
  3. Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase. Shiozuka K, et al. Gene, 1995 Sep 11. PMID 7557444
  4. A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. Blanco-Aparicio C, et al. J Cell Biol, 1999 Dec 13. PMID 10601328, Free PMC Article
  5. Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Lin G, et al. Genes Dev, 2011 Jul 1. PMID 21724833, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERBB2 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERBB2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neuron differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
NOT involved_in regulation of homophilic cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase R
Names
protein-tyrosine phosphatase PCPTP1
tyrosine phosphatase CBPTP
NP_001106861.1
NP_446046.2
XP_063120425.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113390.1 → NP_001106861.1  receptor-type tyrosine-protein phosphatase R isoform 2

    See identical proteins and their annotated locations for NP_001106861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two 5' exons but has an alternate 5' UTR exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    BC089186, D64050
    UniProtKB/TrEMBL
    A0A0G2JYG7, A6IGM2
    Related
    ENSRNOP00000070648.2, ENSRNOT00000085073.3
    Conserved Domains (2) summary
    smart00194
    Location:270 → 522
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:295 → 522
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_053594.2 → NP_446046.2  receptor-type tyrosine-protein phosphatase R isoform 1 precursor

    See identical proteins and their annotated locations for NP_446046.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC089186, D38292, D64050
    UniProtKB/Swiss-Prot
    O08617, Q62695, Q63419
    UniProtKB/TrEMBL
    A6IGM0, G3V6L5
    Related
    ENSRNOP00000006401.3, ENSRNOT00000006401.6
    Conserved Domains (2) summary
    smart00194
    Location:391 → 643
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:416 → 643
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    53548611..53815632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264355.1 → XP_063120425.1  receptor-type tyrosine-protein phosphatase R isoform X1

    UniProtKB/Swiss-Prot
    O08617, Q62695, Q63419
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08617.2 GenPept UniProtKB/Swiss-Prot:O08617

Gene LinkOut

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