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MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [ Homo sapiens (human) ]

Gene ID: 9448, updated on 28-Oct-2024

Summary

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Official Symbol
MAP4K4provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4provided by HGNC
Primary source
HGNC:HGNC:6866
See related
Ensembl:ENSG00000071054 MIM:604666; AllianceGenome:HGNC:6866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGK; NIK; MEKKK4; FLH21957; HEL-S-31
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 42.7), fat (RPKM 25.1) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See MAP4K4 in Genome Data Viewer
Location:
2q11.2
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101697707..101894690)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102156317..102352940)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102314169..102511152)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102150441-102151230 Neighboring gene uncharacterized LOC105373514 Neighboring gene PRCP pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr2:102182961-102183536 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:102224391-102224936 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:102225481-102226024 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:102226025-102226568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16302 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102304849-102305051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16304 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:102358485-102359214 Neighboring gene Sharpr-MPRA regulatory region 8953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102422933-102423868 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102424513-102425121 Neighboring gene Sharpr-MPRA regulatory region 3767 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:102509916-102510686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16305 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102552199-102552715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102599375-102599875 Neighboring gene long intergenic non-protein coding RNA 1127 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102637443-102637636 Neighboring gene interleukin 1 receptor type 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastoma. Santhana Kumar K, et al. Springerplus, 2015. PMID 25625039, Free PMC Article
  2. Bioinformatics and Experimental Analyses Reveal MAP4K4 as a Potential Marker for Gastric Cancer. Zhang J, et al. Genes (Basel), 2022 Oct 3. PMID 36292671, Free PMC Article
  3. Integrated exome and transcriptome analysis prioritizes MAP4K4 de novo frameshift variants in autism spectrum disorder as a novel disease-gene association. Cesana M, et al. Hum Genet, 2023 Mar. PMID 36469137, Free PMC Article
  4. MAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility. Wan C, et al. Cells, 2022 Nov 28. PMID 36497065, Free PMC Article
  5. Lowered HGK expression inhibits cell invasion and adhesion in hepatocellular carcinoma cell line HepG2. Han SX, et al. World J Gastroenterol, 2010 Sep 28. PMID 20857524, Free PMC Article

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Signaling in Liver and Metabolic Diseases.
    Title: Role of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Signaling in Liver and Metabolic Diseases.
  2. Syndromic craniosynostosis caused by a novel missense variant in MAP4K4: Expanding the genotype-phenotype relationship in RASopathies.
    Title: Syndromic craniosynostosis caused by a novel missense variant in MAP4K4: Expanding the genotype-phenotype relationship in RASopathies.
  3. MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1.
    Title: MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1.
  4. FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner.
    Title: FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner.
  5. MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFbeta2-Smad2/3 signaling pathway in cervical cancer.
    Title: MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer.
  6. CircCPSF6 promotes hepatocellular carcinoma cancer progression by regulating MAP4K4 through sponging miR-145-5p.
    Title: CircCPSF6 promotes hepatocellular carcinoma cancer progression by regulating MAP4K4 through sponging miR-145-5p.
  7. Evaluation of the Role of MAP4K4 in Focal Adhesion Dynamics and Regulation of Cell Migration of Breast Cancer Cell Line MDA-MB-231.
    Title: Evaluation of the Role of MAP4K4 in Focal Adhesion Dynamics and Regulation of Cell Migration of Breast Cancer Cell Line MDA-MB-231.
  8. MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage.
    Title: MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage.
  9. Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish.
    Title: Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish.
  10. Integrated exome and transcriptome analysis prioritizes MAP4K4 de novo frameshift variants in autism spectrum disorder as a novel disease-gene association.
    Title: Integrated exome and transcriptome analysis prioritizes MAP4K4 de novo frameshift variants in autism spectrum disorder as a novel disease-gene association.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10410, FLJ20373, FLJ90111, KIAA0687

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables creatine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in microvillus assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell-matrix adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ARF protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of focal adhesion disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of keratinocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 4
Names
HPK/GCK-like kinase HGK
MAPK/ERK kinase kinase kinase 4
MEK kinase kinase 4
Ste20 group protein kinase HGK
epididymis secretory protein Li 31
hepatocyte progenitor kinase-like/germinal center kinase-like kinase
nck-interacting kinase
NP_001229488.1
NP_001229489.1
NP_001371405.1
NP_001371406.1
NP_001371407.1
NP_001371410.1
NP_001371411.1
NP_001371412.1
NP_001371413.1
NP_001371414.1
NP_001371415.1
NP_001371416.1
NP_001371417.1
NP_001371419.1
NP_001371420.1
NP_001371421.1
NP_001371422.1
NP_001371423.1
NP_001371424.1
NP_001371425.1
NP_001371426.1
NP_001371435.1
NP_001371436.1
NP_001371437.1
NP_001371438.1
NP_001371449.1
NP_001371472.1
NP_001371477.1
NP_001371478.1
NP_001371479.1
NP_001371480.1
NP_001371481.1
NP_001371482.1
NP_001371483.1
NP_001371484.1
NP_001371485.1
NP_001371486.1
NP_001371487.1
NP_001371488.1
NP_001371489.1
NP_001371490.1
NP_001371491.1
NP_001371492.1
NP_001371493.1
NP_001371496.1
NP_001371501.1
NP_001371508.1
NP_001381931.1
NP_004825.3
NP_663719.2
NP_663720.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242559.2 → NP_001229488.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

    See identical proteins and their annotated locations for NP_001229488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses two alternate in-frame splice sites and lacks an alternate in-frame exon in the central coding region, compared to variant 2. The encoded isoform (4) is shorter than isoform 2. The 5' UTR of this variant is incomplete due to a lack of 5'-complete transcripts representing this variant, and the presence of splicing ambiguity in the 5' UTR.
    Source sequence(s)
    AC005035, AC007005, AY212247, BU625485, DB086475
    Consensus CDS
    CCDS56130.1
    UniProtKB/Swiss-Prot
    E7ESS2, O75172, O95819, Q9NST7
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Related
    ENSP00000314363.6, ENST00000347699.8
    Conserved Domains (2) summary
    smart00036
    Location:921 → 1219
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001242560.2 → NP_001229489.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons but includes two different alternate in-frame exons in the central coding region, compared to variant 2. The encoded isoform (5) is shorter than isoform 2.
    Source sequence(s)
    AC005035, AC007005, AK296396, BU625485, DR002278
    Consensus CDS
    CCDS92823.1
    UniProtKB/TrEMBL
    B7Z3V5, E7EN19
    Related
    ENSP00000392830.2, ENST00000425019.6
    Conserved Domains (3) summary
    smart00036
    Location:917 → 1215
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001384476.1 → NP_001371405.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:947 → 1245
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001384477.1 → NP_001371406.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:1010 → 1308
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001384478.1 → NP_001371407.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:840 → 1138
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  6. NM_001384481.1 → NP_001371410.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Conserved Domains (2) summary
    smart00036
    Location:986 → 1292
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  7. NM_001384482.1 → NP_001371411.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Related
    ENSP00000389752.1, ENST00000413150.6
    Conserved Domains (2) summary
    smart00036
    Location:837 → 1135
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  8. NM_001384483.1 → NP_001371412.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:931 → 1229
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  9. NM_001384484.1 → NP_001371413.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:948 → 1246
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  10. NM_001384485.1 → NP_001371414.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:948 → 1254
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  11. NM_001384486.1 → NP_001371415.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Conserved Domains (2) summary
    smart00036
    Location:989 → 1287
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  12. NM_001384487.1 → NP_001371416.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:978 → 1276
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  13. NM_001384488.1 → NP_001371417.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Conserved Domains (2) summary
    smart00036
    Location:988 → 1286
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  14. NM_001384490.1 → NP_001371419.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:871 → 1169
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  15. NM_001384491.1 → NP_001371420.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:916 → 1214
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  16. NM_001384492.1 → NP_001371421.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Conserved Domains (2) summary
    smart00036
    Location:1034 → 1332
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  17. NM_001384493.1 → NP_001371422.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:1012 → 1310
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  18. NM_001384494.1 → NP_001371423.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Related
    ENSP00000387370.1, ENST00000456652.5
    Conserved Domains (2) summary
    smart00036
    Location:870 → 1168
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  19. NM_001384495.1 → NP_001371424.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:904 → 1202
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  20. NM_001384496.1 → NP_001371425.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:932 → 1238
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  21. NM_001384497.1 → NP_001371426.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Conserved Domains (2) summary
    smart00036
    Location:1063 → 1361
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  22. NM_001384506.1 → NP_001371435.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Conserved Domains (2) summary
    smart00036
    Location:1002 → 1300
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  23. NM_001384507.1 → NP_001371436.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Conserved Domains (2) summary
    smart00036
    Location:925 → 1223
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  24. NM_001384508.1 → NP_001371437.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:946 → 1244
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  25. NM_001384509.1 → NP_001371438.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:977 → 1275
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  26. NM_001384520.1 → NP_001371449.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Conserved Domains (2) summary
    smart00036
    Location:968 → 1266
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  27. NM_001384543.1 → NP_001371472.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Conserved Domains (2) summary
    smart00036
    Location:971 → 1269
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  28. NM_001384548.1 → NP_001371477.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:983 → 1281
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  29. NM_001384549.1 → NP_001371478.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z388
    Conserved Domains (2) summary
    smart00036
    Location:895 → 1193
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  30. NM_001384550.1 → NP_001371479.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:910 → 1208
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  31. NM_001384551.1 → NP_001371480.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    H7C360
    Conserved Domains (2) summary
    smart00036
    Location:885 → 1183
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  32. NM_001384552.1 → NP_001371481.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:938 → 1236
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  33. NM_001384553.1 → NP_001371482.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z388
    Conserved Domains (2) summary
    smart00036
    Location:1001 → 1299
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  34. NM_001384554.1 → NP_001371483.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:905 → 1211
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  35. NM_001384555.1 → NP_001371484.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z388
    Conserved Domains (2) summary
    smart00036
    Location:1003 → 1301
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  36. NM_001384556.1 → NP_001371485.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:936 → 1234
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  37. NM_001384557.1 → NP_001371486.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    H7C360
    Related
    ENSP00000409720.1, ENST00000417294.5
    Conserved Domains (2) summary
    smart00036
    Location:882 → 1180
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  38. NM_001384558.1 → NP_001371487.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:908 → 1206
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  39. NM_001384559.1 → NP_001371488.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 46

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z388
    Conserved Domains (2) summary
    smart00036
    Location:894 → 1192
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  40. NM_001384560.1 → NP_001371489.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 47

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    H7C360
    Conserved Domains (2) summary
    smart00036
    Location:859 → 1157
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  41. NM_001384561.1 → NP_001371490.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 48

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:831 → 1129
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  42. NM_001384562.1 → NP_001371491.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 49

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:937 → 1235
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  43. NM_001384563.1 → NP_001371492.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 50

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z388
    Conserved Domains (2) summary
    smart00036
    Location:1000 → 1298
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  44. NM_001384564.1 → NP_001371493.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 51

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    A0A0D9SEY1
    Conserved Domains (2) summary
    smart00036
    Location:1023 → 1321
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  45. NM_001384567.1 → NP_001371496.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 52

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z388
    Conserved Domains (2) summary
    smart00036
    Location:972 → 1270
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  46. NM_001384572.1 → NP_001371501.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 53

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    B7Z3V5
    Conserved Domains (2) summary
    smart00036
    Location:939 → 1237
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  47. NM_001384579.1 → NP_001371508.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 54

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    UniProtKB/TrEMBL
    H7C360
    Conserved Domains (2) summary
    smart00036
    Location:916 → 1214
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:6 → 280
    PKc_like; Protein Kinases, catalytic domain

  48. NM_001395002.1 → NP_001381931.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 55

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005
    Consensus CDS
    CCDS92821.1
    UniProtKB/TrEMBL
    A0A0D9SEY1, G5E948
    Related
    ENSP00000313644.6, ENST00000324219.9
    Conserved Domains (2) summary
    smart00036
    Location:1066 → 1364
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  49. NM_004834.5 → NP_004825.3  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_004825.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two alternate in-frame exons but includes a different in-frame exon in the central coding region, and uses an alternate in-frame splice site in both the central and 3' coding regions, compared to variant 2. The encoded isoform (1) is shorter than isoform 2.
    Source sequence(s)
    AC005035, AC007005, AF096300, BU625485, DR002278
    Consensus CDS
    CCDS82487.1
    UniProtKB/TrEMBL
    B7Z3V5
    Related
    ENSP00000489579.1, ENST00000634702.1
    Conserved Domains (2) summary
    smart00036
    Location:839 → 1145
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06636
    Location:8 → 289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

  50. NM_145686.4 → NP_663719.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_663719.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC005035, AC007005, BC064691, BU625485, DR002278
    Consensus CDS
    CCDS74546.1
    UniProtKB/TrEMBL
    H7C360
    Related
    ENSP00000343658.5, ENST00000350878.9
    Conserved Domains (2) summary
    smart00036
    Location:955 → 1253
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  51. NM_145687.4 → NP_663720.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

    See identical proteins and their annotated locations for NP_663720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon but includes a different in-frame exon in the central coding region, compared to variant 2. The encoded isoform (3) is shorter than isoform 2. The 5' UTR of this variant is incomplete due to a lack of 5'-complete transcripts representing this variant, and the presence of splicing ambiguity in the 5' UTR.
    Source sequence(s)
    AB014587, AC005035, AC007005, BU625485, DB086475
    Consensus CDS
    CCDS92822.1
    UniProtKB/TrEMBL
    H7C360, V9HWH3
    Related
    ENSP00000486116.2, ENST00000625522.3
    Conserved Domains (2) summary
    smart00036
    Location:894 → 1192
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_169279.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005

  2. NR_169280.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005

  3. NR_169281.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005

  4. NR_169282.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005035, AC007005

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101697707..101894690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    102156317..102352940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95819.2 GenPept UniProtKB/Swiss-Prot:O95819

Gene LinkOut

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