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aer aerotaxis receptor [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945301, updated on 19-Sep-2024

Summary

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Official Symbol
aer
Official Full Name
aerotaxis receptor
Primary source
ECOCYC:G7595
Locus tag
b3072
See related
ASAP:ABE-0010087
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
air; ECK3062; yqjJ
Summary
Energy taxis includes aerotaxis, redox taxis and glycerol taxis. aer is up-regulated by FlhCD and CRP. aer mutants are down for genes involved in anaerobic respiration and the Entner-Doudoroff pathway. [More information is available at EcoGene: EG12955]. The flavoprotein Aer is one of two sensory proteins which mediate the aerotactic response in Escherichia coli. [More information is available at EcoCyc: G7595].
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Genomic context

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Sequence:
NC_000913.3 (3217556..3219076, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADPH-dependent ferric-chelate reductase Neighboring gene DNA-binding transcriptional repressor NfeR Neighboring gene putrescine aminotransferase Neighboring gene putative tRNA-binding protein YgjH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In search of higher energy: metabolism-dependent behaviour in bacteria. Taylor BL, et al. Mol Microbiol, 1998 May. PMID 9643537
  2. Aerotactic responses in bacteria to photoreleased oxygen. Yu HS, et al. FEMS Microbiol Lett, 2002 Dec 17. PMID 12480110
  3. An alternative strategy for adaptation in bacterial behavior. Taylor BL. J Bacteriol, 2004 Jun. PMID 15175278, Free PMC Article
  4. Interactions between the PAS and HAMP domains of the Escherichia coli aerotaxis receptor Aer. Watts KJ, et al. J Bacteriol, 2004 Nov. PMID 15489456, Free PMC Article
  5. The Aer protein of Escherichia coli forms a homodimer independent of the signaling domain and flavin adenine dinucleotide binding. Ma Q, et al. J Bacteriol, 2004 Nov. PMID 15489458, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blue light is a universal signal for Escherichia coli chemoreceptors.
    Title: Blue Light Is a Universal Signal for Escherichia coli Chemoreceptors.
  2. Oxidized Aer activates CheA, whereas ASQ Aer reversibly inhibits CheA.
    Title: Bacterial Energy Sensor Aer Modulates the Activity of the Chemotaxis Kinase CheA Based on the Redox State of the Flavin Cofactor.
  3. These studies demonstrated trigonal interactions among the F1 linkers from three Aer monomers, presumably within trimer-of-dimer units, as well as binary interactions between subunits.
    Title: Role of the F1 region in the Escherichia coli aerotaxis receptor Aer.
  4. Gain-of-function mutations are associated with the signalling pathway in the PAS domain of Aer.
    Title: Gain-of-function mutations cluster in distinct regions associated with the signalling pathway in the PAS domain of the aerotaxis receptor, Aer.
  5. The aer mutant exhibited a decreased ability to colonize the intestine when compared to wild-type cells.
    Title: An Escherichia coli aer mutant exhibits a reduced ability to colonize the streptomycin-treated mouse large intestine.
  6. Data confirmed that the Aer HAMP domain is composed of two alpha-helices separated by a structured loop and significance of the HAMP and proximal signaling domain structure for signal transduction is discussed.
    Title: Structure-function relationships in the HAMP and proximal signaling domains of the aerotaxis receptor Aer.
  7. the overall membrane organization of Aer included a maximum of three Aer dimers, did not swap neighbors over time, and appeared to be constrained by interactions in the cytosolic signaling domain.
    Title: Organization of the aerotaxis receptor aer in the membrane of Escherichia coli.
  8. Either the PAS or signalling domains could be deleted from the non-signalling subunit of the Aer heterodimer, but removing 16 residues from the C-terminus of the signalling subunit abolished aerotaxis.
    Title: Minimal requirements for oxygen sensing by the aerotaxis receptor Aer.
  9. EilA activates the genetically linked high molecular weight bacterial surface protein Air
    Title: EilA, a HilA-like regulator in enteroaggregative Escherichia coli.
  10. strong Aer responses to oxygen are associated with redox changes in NADH dehydrogenase I
    Title: Differentiation between electron transport sensing and proton motive force sensing by the Aer and Tsr receptors for aerotaxis.
Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive aerotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aerotaxis receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3217556..3219076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417543.1 aerotaxis receptor [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417543.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8R5H2
    Conserved Domains (2) summary
    smart00283
    Location:259 → 506
    MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
    pfam08447
    Location:30 → 115
    PAS_3; PAS fold
Nucleotide Protein
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