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zapC cell division protein ZapC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945552, updated on 19-Sep-2024

Summary

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Official Symbol
zapC
Official Full Name
cell division protein ZapC
Primary source
ECOCYC:G6486
Locus tag
b0946
See related
ASAP:ABE-0003204
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0937; ycbW
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Genomic context

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Sequence:
NC_000913.3 (1005952..1006494)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YcbV Neighboring gene putative fimbrial chaperone YcbF Neighboring gene dihydroorotate dehydrogenase, type 2 Neighboring gene 6-N-hydroxylaminopurine resistance protein Neighboring gene fused 23S rRNA m(2)G2445 methyltransferase and 23S rRNA m(7)G2069 methyltransferase Neighboring gene ATP-binding protein Uup

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli. Durand-Heredia JM, et al. J Bacteriol, 2011 Mar. PMID 21216995, Free PMC Article
  2. Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. Schumacher MA, et al. J Biol Chem, 2016 Jan 29. PMID 26655719, Free PMC Article
  3. Crystal structure of the Z-ring associated cell division protein ZapC from Escherichia coli. Ortiz C, et al. FEBS Lett, 2015 Dec 21. PMID 26619764, Free PMC Article
  4. Identification of Escherichia coli ZapC (YcbW) as a component of the division apparatus that binds and bundles FtsZ polymers. Hale CA, et al. J Bacteriol, 2011 Mar. PMID 21216997, Free PMC Article
  5. Interaction network containing conserved and essential protein complexes in Escherichia coli. Butland G, et al. Nature, 2005 Feb 3. PMID 15690043

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors report the identification of an FtsZ stabilizer, ZapC (Z-associated protein C), in a protein localization screen conducted with E. coli.
    Title: Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli.
  2. ZapC binds the large FtsZ globular core rather than C-terminal tail, and the presence of two adjacent pockets suggests possible mechanisms for ZapC-mediated FtsZ bundling
    Title: Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC.
  3. Binding of YcbW (ZapC) to FtsZ promotes lateral interactions between FtsZ polymers and suppresses FtsZ GTPase activity.
    Title: Identification of Escherichia coli ZapC (YcbW) as a component of the division apparatus that binds and bundles FtsZ polymers.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within FtsZ-dependent cytokinesis EXP
Inferred from Experiment
more info
 PubMed 
involved_in FtsZ-dependent cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell septum assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in division septum assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cell division protein ZapC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1005952..1006494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415466.4 cell division protein ZapC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415466.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7NQX7, W1WDG5
    Conserved Domains (1) summary
    pfam07126
    Location:2 → 167
    ZapC; Cell-division protein ZapC
Nucleotide Protein
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