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PICK1 protein interacting with PRKCA 1 [ Homo sapiens (human) ]

Gene ID: 9463, updated on 11-Apr-2024

Summary

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Official Symbol
PICK1provided by HGNC
Official Full Name
protein interacting with PRKCA 1provided by HGNC
Primary source
HGNC:HGNC:9394
See related
Ensembl:ENSG00000100151 MIM:605926; AllianceGenome:HGNC:9394
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PICK; PRKCABP
Summary
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 10.0), testis (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
22q13.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38057255..38075701)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38518878..38537327)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38453262..38471708)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase II, I and III subunit F Neighboring gene MPRA-validated peak4487 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38378831-38379668 Neighboring gene VISTA enhancer hs564 Neighboring gene SRY-box transcription factor 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38392633-38393194 Neighboring gene VISTA enhancer hs486 Neighboring gene microRNA 4534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38424434-38424934 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:38427029-38428228 Neighboring gene VISTA enhancer hs491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38438297-38438796 Neighboring gene VISTA enhancer hs492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38446442-38446942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38446943-38447443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38452863-38453488 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38453489-38454112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38470967-38471468 Neighboring gene uncharacterized LOC105373027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38476553-38477334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38479675-38480456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38482017-38482796 Neighboring gene solute carrier family 16 member 8 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38494339-38494893

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Scaffold Protein PICK1 as a Target in Chronic Pain. Sørensen AT, et al. Cells, 2022 Apr 7. PMID 35455935, Free PMC Article
  2. Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis. Andersen RC, et al. J Clin Invest, 2022 Mar 1. PMID 35077398, Free PMC Article
  3. Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer. Zhou Y, et al. Med Oncol, 2021 Mar 4. PMID 33660148
  4. PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval. Yong XLH, et al. Cell Rep, 2020 Oct 27. PMID 33113376
  5. A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain. Christensen NR, et al. EMBO Mol Med, 2020 Jun 8. PMID 32352640, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
    Title: Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.
  2. Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.
    Title: Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells.
  3. The Scaffold Protein PICK1 as a Target in Chronic Pain.
    Title: The Scaffold Protein PICK1 as a Target in Chronic Pain.
  4. Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.
    Title: Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.
  5. Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.
    Title: Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.
  6. PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
    Title: PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval.
  7. Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.
    Title: Protein interacting with C-kinase 1 is involved in epithelial-mesenchymal transformation and suppresses progress of gastric cancer.
  8. PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
    Title: PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
  9. A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
    Title: A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
  10. Arf1, AP1, and PICK1 are key coordinators of actin polymerization.
    Title: The Host GTPase Arf1 and Its Effectors AP1 and PICK1 Stimulate Actin Polymerization and Exocytosis To Promote Entry of Listeria monocytogenes.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC15204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Arp2/3 complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables G protein-coupled receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables membrane curvature sensor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase C binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to decreased oxygen levels ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendritic spine maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendritic spine maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendritic spine organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glial cell development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-term synaptic depression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monoamine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuronal ion channel clustering TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PRKCA-binding protein
Names
protein interacting with C kinase 1
protein kinase C-alpha-binding protein

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039583.1 → NP_001034672.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_001034672.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561, CN482899
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    B3KS52, O95906, Q9NRD5
    UniProtKB/TrEMBL
    B3KM22
    Related
    ENSP00000385205.3, ENST00000404072.7
    Conserved Domains (2) summary
    cd07659
    Location:146 → 360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:19 → 99
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

  2. NM_001039584.1 → NP_001034673.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_001034673.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    B3KS52, O95906, Q9NRD5
    UniProtKB/TrEMBL
    B3KM22
    Related
    ENST00000484021.5
    Conserved Domains (2) summary
    cd07659
    Location:146 → 360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:19 → 99
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

  3. NM_012407.4 → NP_036539.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_036539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    B3KS52, O95906, Q9NRD5
    UniProtKB/TrEMBL
    B3KM22
    Related
    ENSP00000349465.3, ENST00000356976.8
    Conserved Domains (2) summary
    cd07659
    Location:146 → 360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:19 → 99
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    38057255..38075701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441609.1 → XP_047297565.1  PRKCA-binding protein isoform X1

  2. XM_047441610.1 → XP_047297566.1  PRKCA-binding protein isoform X1

  3. XM_011530517.4 → XP_011528819.1  PRKCA-binding protein isoform X1

    UniProtKB/TrEMBL
    B3KM22
    Conserved Domains (2) summary
    cd07659
    Location:147 → 342
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:19 → 99
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

  4. XM_047441611.1 → XP_047297567.1  PRKCA-binding protein isoform X2

  5. XM_047441613.1 → XP_047297569.1  PRKCA-binding protein isoform X4

  6. XM_047441612.1 → XP_047297568.1  PRKCA-binding protein isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38518878..38537327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326142.1 → XP_054182117.1  PRKCA-binding protein isoform X1

  2. XM_054326143.1 → XP_054182118.1  PRKCA-binding protein isoform X1

  3. XM_054326141.1 → XP_054182116.1  PRKCA-binding protein isoform X1

  4. XM_054326144.1 → XP_054182119.1  PRKCA-binding protein isoform X2

  5. XM_054326146.1 → XP_054182121.1  PRKCA-binding protein isoform X4

  6. XM_054326145.1 → XP_054182120.1  PRKCA-binding protein isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRD5.2 GenPept UniProtKB/Swiss-Prot:Q9NRD5

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