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nrdE ribonucleoside-diphosphate reductase 2 subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947155, updated on 19-Sep-2024

Summary

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Official Symbol
nrdE
Official Full Name
ribonucleoside-diphosphate reductase 2 subunit alpha
Primary source
ECOCYC:EG20257
Locus tag
b2675
See related
ASAP:ABE-0008806
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2669
Summary
nrdE is a nonessential gene. [More information is available at EcoGene: EG20257]. Expression of the nrdHIEF operon is increased by hydroxyurea and oxidative stress . [More information is available at EcoCyc: EG20257].
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Genomic context

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Sequence:
NC_000913.3 (2801348..2803492)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF883 domain-containing protein YgaM Neighboring gene glutaredoxin-like protein NrdH Neighboring gene dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI Neighboring gene ribonucleoside-diphosphate reductase 2 subunit beta Neighboring gene glycine betaine ABC transporter ATP binding subunit ProV Neighboring gene glycine betaine ABC transporter membrane subunit ProW

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation. Martin JE, et al. Mol Microbiol, 2011 Apr. PMID 21338418, Free PMC Article
  2. A second class I ribonucleotide reductase in Enterobacteriaceae: characterization of the Salmonella typhimurium enzyme. Jordan A, et al. Proc Natl Acad Sci U S A, 1994 Dec 20. PMID 7809142, Free PMC Article
  3. Bacterial transposon Tn7 utilizes two different classes of target sites. Kubo KM, et al. J Bacteriol, 1990 May. PMID 2158980, Free PMC Article
  4. NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Cotruvo JA Jr, et al. Proc Natl Acad Sci U S A, 2008 Sep 23. PMID 18799738, Free PMC Article
  5. Expression analysis of the nrdHIEF operon from Escherichia coli. Conditions that trigger the transcript level in vivo. Monje-Casas F, et al. J Biol Chem, 2001 May 25. PMID 11278973

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thus NrdEF supports DNA replication when iron is unavailable to activate the housekeeping NrdAB enzyme.
    Title: The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation.
  2. Functional long-range proton-coupled electron transfer in ribonucleoside diphosphate reductase occurs via an optimized pathway of amino acids spanning >35 A across the alpha:beta interface.
    Title: Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in deoxyribonucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within nucleobase-containing small molecule interconversion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribonucleoside diphosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ribonucleoside-diphosphate reductase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoside-diphosphate reductase complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of ribonucleoside-diphosphate reductase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ribonucleoside-diphosphate reductase 2 subunit alpha
NP_417161.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2801348..2803492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417161.1 ribonucleoside-diphosphate reductase 2 subunit alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417161.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EHH1
    Conserved Domains (1) summary
    PRK08188
    Location:1 → 714
    PRK08188; ribonucleotide-diphosphate reductase subunit alpha; Validated
Nucleotide Protein
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