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nrdI dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947158, updated on 19-Sep-2024

Summary

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Official Symbol
nrdI
Official Full Name
dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI
Primary source
ECOCYC:G7402
Locus tag
b2674
See related
ASAP:ABE-0008804
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2668; ygaO
Summary
NrdI is a flavodoxin that mediates maintenance of the diferric-tyrosyl radical cofactor of NrdF, the subunit of the class Ib ribonucleotide reductase . [More information is available at EcoCyc: G7402].
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Genomic context

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Sequence:
NC_000913.3 (2800965..2801375)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2002 domain-containing protein YgaC Neighboring gene DUF883 domain-containing protein YgaM Neighboring gene glutaredoxin-like protein NrdH Neighboring gene ribonucleoside-diphosphate reductase 2 subunit alpha Neighboring gene ribonucleoside-diphosphate reductase 2 subunit beta Neighboring gene glycine betaine ABC transporter ATP binding subunit ProV Neighboring gene glycine betaine ABC transporter membrane subunit ProW

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis for activation of class Ib ribonucleotide reductase. Boal AK, et al. Science, 2010 Sep 17. PMID 20688982, Free PMC Article
  2. An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Cotruvo JA Jr, et al. Biochemistry, 2010 Feb 16. PMID 20070127, Free PMC Article
  3. NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Cotruvo JA Jr, et al. Proc Natl Acad Sci U S A, 2008 Sep 23. PMID 18799738, Free PMC Article
  4. Expression analysis of the nrdHIEF operon from Escherichia coli. Conditions that trigger the transcript level in vivo. Monje-Casas F, et al. J Biol Chem, 2001 May 25. PMID 11278973
  5. Characterization of Escherichia coli NrdH. A glutaredoxin-like protein with a thioredoxin-like activity profile. Jordan A, et al. J Biol Chem, 1997 Jul 18. PMID 9218434

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2800965..2801375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417160.1 dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417160.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1MQP8
    Conserved Domains (1) summary
    PRK03600
    Location:1 → 134
    nrdI; class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI
Nucleotide Protein
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