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tdcA DNA-binding transcriptional activator TdcA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947494, updated on 19-Sep-2024

Summary

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Official Symbol
tdcA
Official Full Name
DNA-binding transcriptional activator TdcA
Primary source
ECOCYC:EG10989
Locus tag
b3118
See related
ASAP:ABE-0010252
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3107
Summary
During anaerobiosis, TdcA participates in controlling genes (tdc operon) involved in transport and metabolism of threonine and serine . [More information is available at EcoCyc: EG10989].
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Genomic context

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Sequence:
NC_000913.3 (3266127..3267065, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene threonine/serine:H(+) symporter Neighboring gene catabolic threonine dehydratase Neighboring gene DNA-binding transcriptional activator TdcR Neighboring gene protein YhaB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TdcA, a transcriptional activator of the tdcABC operon of Escherichia coli, is a member of the LysR family of proteins. Ganduri YL, et al. Mol Gen Genet, 1993 Sep. PMID 8413189
  2. Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase. Rodrigues GA, et al. Mol Cell Biol, 1993 Nov. PMID 8413267, Free PMC Article
  3. Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA. Gonidakis S, et al. Aging (Albany NY), 2011 Mar. PMID 21464517, Free PMC Article
  4. Molecular cloning and expression of the biodegradative threonine dehydratase gene (tdc) of Escherichia coli K12. Goss TJ, et al. Mol Gen Genet, 1985. PMID 3003533
  5. Multiple elements controlling adherence of enterohemorrhagic Escherichia coli O157:H7 to HeLa cells. Torres AG, et al. Infect Immun, 2003 Sep. PMID 12933841, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data are consistent with the hypothesis that ArcA and TdcA function in the same genetic pathway to increase lifespan and enhance oxidative stress resistance in the ubiG mutant
    Title: Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA.
  2. Transcriptional analysis revealed that tdcA expression in Escherichia coli is higher under anaerobic than aerobic growth conditions, but the opposite is true in Salmonella typhimurium.
    Title: Comparison of tdcA expression between Escherichia coli and Salmonella enterica serovar Typhimurium.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-threonine catabolic process to propionate IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional activator TdcA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3266127..3267065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417588.1 DNA-binding transcriptional activator TdcA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417588.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1N0A7, A0A5B9APT9, A0A895NZZ6
    Conserved Domains (1) summary
    PRK10341
    Location:1 → 312
    PRK10341; transcriptional regulator TdcA
Nucleotide Protein
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