ibpB small heat shock protein IbpB [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: ibpB
Official Full Name: small heat shock protein IbpB
Primary source: ECOCYC:EG11535
Locus tag: b3686
See related: ASAP:ABE-0012054
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3678; hslS; htpE
Summary: RpoH regulon. [More information is available at EcoGene: EG11535]. IbpB is a small heat shock protein that binds to aggregated proteins and inclusion bodies formed during heterologous protein expression . [More information is available at EcoCyc: EG11535].
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Genomic context

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Sequence:: NC_000913.3 (3866469..3866897, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IbpAB small heat shock proteins are not host factors for bacteriophage varphiX174 replication.
Title: IbpAB small heat shock proteins are not host factors for bacteriophage ϕX174 replication.
An RNA thermometer in its 5' untranslated region, forming a secondary structure upstream of ibpB is functional in vitro but not in vivo, suggesting downregulation of ibpB expression in the presence of IbpA.
Title: Multiple layers of control govern expression of the Escherichia coli ibpAB heat-shock operon.
The authors report that IbpA and IbpB, the sHSPs of Escherichia coli, are substrates for the AAA+ Lon protease.
Title: The IbpA and IbpB small heat-shock proteins are substrates of the AAA+ Lon protease.
The lack of IbpAB proteins in E. coli cells results in endogenous oxidative stress and overproduction of extracellular indole, which inhibits the growth of the biofilm at the air-liquid interface.
Title: Escherichia coli heat-shock proteins IbpA and IbpB affect biofilm formation by influencing the level of extracellular indole.
N-terminus verified by Edman degradation on complete protein
Title: Two novel heat shock genes encoding proteins produced in response to heterologous protein expression in Escherichia coli.
the flexible termini appear to be essential for small heat shock protein IbpB to generate various temperature-responsive oligomers, which exhibit various levels of chaperone-like activities, by interlinking or separating the dimer building blocks
Title: The essential role of the flexible termini in the temperature-responsiveness of the oligomeric state and chaperone-like activity for the polydisperse small heat shock protein IbpB from Escherichia coli.
IbpA cooperates with IbpB in stabilization of thermally aggregated proteins in a disaggregation competent state
Title: The small heat shock protein IbpA of Escherichia coli cooperates with IbpB in stabilization of thermally aggregated proteins in a disaggregation competent state.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stress response to copper ion	IMP Inferred from Mutant Phenotype more info	PubMed