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IGDCC3 immunoglobulin superfamily DCC subclass member 3 [ Homo sapiens (human) ]

Gene ID: 9543, updated on 3-Apr-2024

Summary

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Official Symbol
IGDCC3provided by HGNC
Official Full Name
immunoglobulin superfamily DCC subclass member 3provided by HGNC
Primary source
HGNC:HGNC:9700
See related
Ensembl:ENSG00000174498 MIM:604184; AllianceGenome:HGNC:9700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PUNC; HsT18880
Summary
Predicted to act upstream of or within neuromuscular process controlling balance. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta (RPKM 4.0), testis (RPKM 2.0) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
15q22.31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65327127..65378002, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (63136500..63187366, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65619465..65670340, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:65588516-65589427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65593529-65594044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6555 Neighboring gene RNA, U5A small nuclear 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9595 Neighboring gene RNA, U5B small nuclear 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65618173-65618716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65624736-65625408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65626438-65627016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65627017-65627595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65628175-65628752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65647365-65647867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65647868-65648370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65648371-65648873 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65655395-65656260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65659717-65660580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65660581-65661444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65677106-65677717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9598 Neighboring gene immunoglobulin superfamily DCC subclass member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65702937-65703594 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65707062-65707929 Neighboring gene uncharacterized LOC124903510 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:65710136-65710346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9600 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:65715563-65716097 Neighboring gene dipeptidyl peptidase 8 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65809274-65809827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9601

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genomic structure and chromosomal localization of the mouse gene Punc. Salbaum JM. Mamm Genome, 1999 Feb. PMID 9922388
  2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily DCC subclass member 3
Names
putative neuronal cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004884.4 → NP_004875.2  immunoglobulin superfamily DCC subclass member 3 precursor

    See identical proteins and their annotated locations for NP_004875.2

    Status: VALIDATED

    Source sequence(s)
    AC105129, AI740721, BC067107
    Consensus CDS
    CCDS10205.1
    UniProtKB/Swiss-Prot
    O95215, Q8IVU1
    Related
    ENSP00000332773.4, ENST00000327987.9
    Conserved Domains (6) summary
    cd00096
    Location:347 → 414
    Ig; Immunoglobulin domain
    smart00410
    Location:244 → 326
    IG_like; Immunoglobulin like
    cd00063
    Location:424 → 517
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:331 → 417
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:522 → 603
    fn3; Fibronectin type III domain
    cl11960
    Location:44 → 135
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    65327127..65378002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522241.3 → XP_011520543.3  immunoglobulin superfamily DCC subclass member 3 isoform X1

  2. XM_011522244.2 → XP_011520546.1  immunoglobulin superfamily DCC subclass member 3 isoform X3

    UniProtKB/TrEMBL
    B3KTG6
    Conserved Domains (6) summary
    cd00096
    Location:210 → 277
    Ig; Immunoglobulin domain
    smart00410
    Location:107 → 189
    IG_like; Immunoglobulin like
    cd00063
    Location:287 → 380
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:194 → 280
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:385 → 466
    fn3; Fibronectin type III domain
    cl11960
    Location:6 → 90
    Ig; Immunoglobulin domain

  3. XM_011522243.1 → XP_011520545.1  immunoglobulin superfamily DCC subclass member 3 isoform X2

    UniProtKB/TrEMBL
    B3KTG6
    Conserved Domains (6) summary
    cd00096
    Location:224 → 291
    Ig; Immunoglobulin domain
    smart00410
    Location:121 → 203
    IG_like; Immunoglobulin like
    cd00063
    Location:301 → 394
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:208 → 294
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:399 → 480
    fn3; Fibronectin type III domain
    cl11960
    Location:20 → 104
    Ig; Immunoglobulin domain

  4. XM_047433374.1 → XP_047289330.1  immunoglobulin superfamily DCC subclass member 3 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    63136500..63187366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379257.1 → XP_054235232.1  immunoglobulin superfamily DCC subclass member 3 isoform X1

  2. XM_054379259.1 → XP_054235234.1  immunoglobulin superfamily DCC subclass member 3 isoform X3

  3. XM_054379258.1 → XP_054235233.1  immunoglobulin superfamily DCC subclass member 3 isoform X2

  4. XM_054379260.1 → XP_054235235.1  immunoglobulin superfamily DCC subclass member 3 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IVU1.2 GenPept UniProtKB/Swiss-Prot:Q8IVU1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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