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CHIKVgp2 structural polyprotein [ Chikungunya virus ]

Gene ID: 956308, updated on 18-Jul-2024

Summary

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Gene symbol
CHIKVgp2
Gene description
structural polyprotein
Locus tag
CHIKVgp2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Chikungunya virus (strain: S27-African prototype)
Lineage
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes; Martellivirales; Togaviridae; Alphavirus
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Genomic context

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Sequence:
NC_004162.2 (7567..11313)

NC_004162.2Genomic Context describing neighboring genes Neighboring gene nonstructural polyprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004162.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Emerging Chikungunya Virus Variants at the E1-E1 Interglycoprotein Spike Interface Impact Virus Attachment and Inflammation. Rangel MV, et al. J Virol, 2022 Feb 23. PMID 34935436, Free PMC Article
  2. Functional dissection of the alphavirus capsid protease: sequence requirements for activity. Thomas S, et al. Virol J, 2010 Nov 18. PMID 21087473, Free PMC Article
  3. Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography. Voss JE, et al. Nature, 2010 Dec 2. PMID 21124458
  4. Entomological investigation and control of a chikungunya cluster in Singapore. Tan CH, et al. Vector Borne Zoonotic Dis, 2011 Apr. PMID 21395419, Free PMC Article
  5. Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence. Tsetsarkin KA, et al. PLoS Pathog, 2011 Dec. PMID 22174678, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chikungunya Virus' High Genomic Plasticity Enables Rapid Adaptation to Restrictive A549 Cells.
    Title: Chikungunya Virus' High Genomic Plasticity Enables Rapid Adaptation to Restrictive A549 Cells.
  2. Emerging Chikungunya Virus Variants at the E1-E1 Interglycoprotein Spike Interface Impact Virus Attachment and Inflammation.
    Title: Emerging Chikungunya Virus Variants at the E1-E1 Interglycoprotein Spike Interface Impact Virus Attachment and Inflammation.
  3. Identification of Peptide Binders to Truncated Recombinant Chikungunya Virus Envelope Protein 2 Using Phage Display Technology and Their In Silico Characterization.
    Title: Identification of Peptide Binders to Truncated Recombinant Chikungunya Virus Envelope Protein 2 Using Phage Display Technology and Their In Silico Characterization.
  4. Continual circulation of ECSA genotype and identification of a novel mutation I317V in the E1 gene of Chikungunya viral strains in southern India during 2015-2016.
    Title: Continual circulation of ECSA genotype and identification of a novel mutation I317V in the E1 gene of Chikungunya viral strains in southern India during 2015-2016.
  5. Conformational changes in Chikungunya virus E2 protein upon heparan sulfate receptor binding explain mechanism of E2-E1 dissociation during viral entry.
    Title: Conformational changes in Chikungunya virus E2 protein upon heparan sulfate receptor binding explain mechanism of E2-E1 dissociation during viral entry.
  6. identifed amino acid residues required for nuclear export and, using replicon systems, showed that mutating the nuclear export sequence of CHIKV capsid protein blocks host protein access to the nucleus
    Title: Mutation of a Conserved Nuclear Export Sequence in Chikungunya Virus Capsid Protein Disrupts Host Cell Nuclear Import.
  7. Structure reveals a chymotrypsin-like protease fold with a conserved hydrophobic pocket in capsid protein for interaction with the cytoplasmic tail of E2.
    Title: Structure-function insights into chikungunya virus capsid protein: Small molecules targeting capsid hydrophobic pocket.
  8. Three novel 6K transmembrane protein-derived epitopes are presented by the common HLA class I molecule, HLA-A*0201.
    Title: Complex antigen presentation pathway for an HLA-A*0201-restricted epitope from Chikungunya 6K protein.
  9. Domains A and B of E2 bound to all cells tested, independently of their permissiveness to Chikungunya Virus infection.
    Title: Identification of Functional Determinants in the Chikungunya Virus E2 Protein.
  10. There are five host proteins interact with E1 and three host proteins interact with E2.
    Title: Host-pathogen interactome analysis of Chikungunya virus envelope proteins E1 and E2.
Submit: New GeneRIF Correction See all GeneRIFs (23)

General protein information

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Preferred Names
structural polyprotein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004162.2 Reference assembly

    Range
    7567..11313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_690589.2 structural polyprotein [Chikungunya virus]

    See identical proteins and their annotated locations for NP_690589.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q80S29, Q8JUX5, Q8QR21
    UniProtKB/TrEMBL
    D7R998
Nucleotide Protein
Heading Accession and Version

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