U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CHIKVgp1 nonstructural polyprotein [ Chikungunya virus ]

Gene ID: 956309, updated on 18-Jul-2024

Summary

Go to the top of the page Help
Gene symbol
CHIKVgp1
Gene description
nonstructural polyprotein
Locus tag
CHIKVgp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Chikungunya virus (strain: S27-African prototype)
Lineage
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes; Martellivirales; Togaviridae; Alphavirus
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_004162.2 (77..7501)

NC_004162.2Genomic Context describing neighboring genes Neighboring gene structural polyprotein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_004162.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3. Remenyi R, et al. J Virol, 2018 Aug 15. PMID 29875241, Free PMC Article
  2. The C-terminal domain of chikungunya virus nsP2 independently governs viral RNA replication, cytopathicity, and inhibition of interferon signaling. Fros JJ, et al. J Virol, 2013 Sep. PMID 23864632, Free PMC Article
  3. Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity. Das PK, et al. J Biol Chem, 2014 Feb 28. PMID 24407286, Free PMC Article
  4. Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus. Nguyen PT, et al. J Mol Model, 2014 May. PMID 24756552, Free PMC Article
  5. Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2. Utt A, et al. J Virol, 2015 Mar. PMID 25552719, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.
    Title: The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.
  2. Chikungunya Virus' High Genomic Plasticity Enables Rapid Adaptation to Restrictive A549 Cells.
    Title: Chikungunya Virus' High Genomic Plasticity Enables Rapid Adaptation to Restrictive A549 Cells.
  3. Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1.
    Title: Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1.
  4. NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
    Title: NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
  5. Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity.
    Title: Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity.
  6. Capping pores of alphavirus nsP1 gate membranous viral replication factories.
    Title: Capping pores of alphavirus nsP1 gate membranous viral replication factories.
  7. Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.
    Title: Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein.
  8. Palmitoylated Cysteines in Chikungunya Virus nsP1 Are Critical for Targeting to Cholesterol-Rich Plasma Membrane Microdomains with Functional Consequences for Viral Genome Replication.
    Title: Palmitoylated Cysteines in Chikungunya Virus nsP1 Are Critical for Targeting to Cholesterol-Rich Plasma Membrane Microdomains with Functional Consequences for Viral Genome Replication.
  9. In conclusion, the non-structural protein 4-R82S mutation provides a greater selective advantage in human cells than in Aedes albopictus, which may explain its apparent natural selection during Chikungunya virus spread in Southeast Asia.
    Title: An amino acid change in nsP4 of chikungunya virus confers fitness advantage in human cell lines rather than in Aedes albopictus.
  10. The authors demonstrate that CD2AP interaction with hypervariable domains of Chikungunya virus nsP3 is mediated by its SH3-A and SH3-C domains, and this leaves the SH3-B domain available for interaction with other cellular factor(s).
    Title: Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 protein.
Submit: New GeneRIF Correction See all GeneRIFs (34)

General protein information

Go to the top of the page Help
Preferred Names
nonstructural polyprotein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004162.2 Reference assembly

    Range
    77..7501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_690588.1 nonstructural polyprotein [Chikungunya virus]

    See identical proteins and their annotated locations for NP_690588.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8JUX6
    UniProtKB/TrEMBL
    A0A068FNV2, D7R997
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.