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ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) [ Homo sapiens (human) ]

Gene ID: 957, updated on 5-Mar-2024

Summary

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Official Symbol
ENTPD5provided by HGNC
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 5 (inactive)provided by HGNC
Primary source
HGNC:HGNC:3367
See related
Ensembl:ENSG00000187097 MIM:603162; AllianceGenome:HGNC:3367
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCPH; CD39L4; NTPDase-5
Summary
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]
Expression
Broad expression in liver (RPKM 43.1), colon (RPKM 29.4) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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See ENTPD5 in Genome Data Viewer
Location:
14q24.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73955329..74019288, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68162983..68226953, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74422032..74485991, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74318268-74318670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8721 Neighboring gene prostaglandin reductase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8722 Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:74416687-74417687 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74418757-74419055 Neighboring gene coenzyme Q6, monooxygenase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74459045-74459546 Neighboring gene Sharpr-MPRA regulatory region 8014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5926 Neighboring gene Sharpr-MPRA regulatory regions 4216 and 10298 Neighboring gene ribosomal protein L41 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36659 Neighboring gene basal body orientation factor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74530601-74530820 Neighboring gene aldehyde dehydrogenase 6 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8725 Neighboring gene RNY4 pseudogene 21 Neighboring gene lin-52 DREAM MuvB core complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ENTPD5 splice variants: novel players in cancer? Arruga F. Purinergic Signal, 2021 Sep. PMID 34272651, Free PMC Article
  2. ENTPD5: identification of splicing variants and their impact on cancer survival. de Campos RP, et al. Purinergic Signal, 2021 Sep. PMID 34075526, Free PMC Article
  3. [ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics]. Wang H, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2021 Apr 20. PMID 33963715, Free PMC Article
  4. ENTPD5 induces apoptosis in lung cancer cells via regulating caspase 3 expression. Xue Y, et al. PLoS One, 2015. PMID 25794010, Free PMC Article
  5. NTPDase5/PCPH as a new target in highly aggressive tumors: a systematic review. Bracco PA, et al. Biomed Res Int, 2014. PMID 25045656, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation.
    Title: The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation.
  2. ENTPD5 splice variants: novel players in cancer?
    Title: ENTPD5 splice variants: novel players in cancer?
  3. ENTPD5: identification of splicing variants and their impact on cancer survival.
    Title: ENTPD5: identification of splicing variants and their impact on cancer survival.
  4. [ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics].
    Title: [ENTPD5 gene is highly expressed in epithelial ovarian cancer: analysis based on Oncomine database and bioinformatics].
  5. ENTPD5 is a mediator of mutant p53 gain of function activity in clonogenic growth, architectural tissue remodeling, migration, invasion, and lung colonization in lung cancer and its mouse models
    Title: Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.
  6. Results suggest that ENTPD5 affects lung cancer apoptosis via Caspase 3 pathway, and can be potentially used to monitor prognosis or to guide appropriate therapeutic regimens.
    Title: ENTPD5 induces apoptosis in lung cancer cells via regulating caspase 3 expression.
  7. The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets.
    Title: NTPDase5/PCPH as a new target in highly aggressive tumors: a systematic review.
  8. These results strongly suggest that the mt-PCPH ( ENTPD5)oncoprotein may regulate the cellular energy levels and subsequent chemoresistance by an NTPDase-independent mechanism
    Title: The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family.
  9. Upregulation of ENTPD5 is associated with altered metabolism in gliomablastoma multiforme.
    Title: ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme.
  10. The elevation of ENTPD5 activity therefore protects AKT-active cancer cells from protein-overloading-induced endoplasmic reticulum stress and the resulting growth arrest and apoptosis.
    Title: ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC163357, MGC163359

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables CDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables IDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_positive_effect 'de novo' post-translational protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in UDP catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_positive_effect UDP-glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_positive_effect protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nucleoside diphosphate phosphatase ENTPD5
Names
CD39 antigen-like 4
CD39-like 4
ER-UDPase
GDPase ENTPD5
NTPDase 5
Pcph proto-oncogene protein
UDPase ENTPD5
guanosine-diphosphatase ENTPD5
inosine diphosphate phosphatase ENTPD5
nucleoside diphosphatase
proto-oncogene CPH
uridine-diphosphatase ENTPD5
NP_001240.1
NP_001308913.1
NP_001308914.1
NP_001308915.1
NP_001308916.1
NP_001308917.1
NP_001317118.1
NP_001369185.1
NP_001369186.1
NP_001369187.1
NP_001369188.1
NP_001369189.1
NP_001369191.1
NP_001369192.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001249.5 → NP_001240.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001240.1

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    A1L4C5, O75356, Q96RX0
    Related
    ENSP00000335246.6, ENST00000334696.11
    Conserved Domains (1) summary
    cl17037
    Location:39 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_001321984.2 → NP_001308913.1  nucleoside diphosphate phosphatase ENTPD5 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Conserved Domains (1) summary
    cl17037
    Location:39 → 400
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. NM_001321985.3 → NP_001308914.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    A1L4C5, O75356, Q96RX0
    Conserved Domains (1) summary
    cl17037
    Location:39 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. NM_001321986.3 → NP_001308915.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    A1L4C5, O75356, Q96RX0
    Conserved Domains (1) summary
    cl17037
    Location:39 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  5. NM_001321987.3 → NP_001308916.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    A1L4C5, O75356, Q96RX0
    Conserved Domains (1) summary
    cl17037
    Location:39 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  6. NM_001321988.3 → NP_001308917.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    A1L4C5, O75356, Q96RX0
    Conserved Domains (1) summary
    cl17037
    Location:39 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  7. NM_001330189.2 → NP_001317118.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484, AW028387
    Consensus CDS
    CCDS81825.1
    UniProtKB/TrEMBL
    G3V4I0
    Conserved Domains (1) summary
    cl17037
    Location:39 → 404
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  8. NM_001382256.1 → NP_001369185.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    A1L4C5, O75356, Q96RX0
    Conserved Domains (1) summary
    cl17037
    Location:39 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  9. NM_001382257.1 → NP_001369186.1  nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS9825.1
    UniProtKB/Swiss-Prot
    A1L4C5, O75356, Q96RX0
    Conserved Domains (1) summary
    cl17037
    Location:39 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  10. NM_001382258.1 → NP_001369187.1  nucleoside diphosphate phosphatase ENTPD5 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Conserved Domains (1) summary
    cl17037
    Location:39 → 410
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  11. NM_001382259.1 → NP_001369188.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS81825.1
    UniProtKB/TrEMBL
    G3V4I0
    Related
    ENSP00000451810.1, ENST00000557325.5
    Conserved Domains (1) summary
    cl17037
    Location:39 → 404
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  12. NM_001382260.1 → NP_001369189.1  nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Consensus CDS
    CCDS81825.1
    UniProtKB/TrEMBL
    G3V4I0
    Conserved Domains (1) summary
    cl17037
    Location:39 → 404
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  13. NM_001382262.1 → NP_001369191.1  nucleoside diphosphate phosphatase ENTPD5 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Conserved Domains (1) summary
    cl17037
    Location:39 → 396
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  14. NM_001382263.1 → NP_001369192.1  nucleoside diphosphate phosphatase ENTPD5 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005480, AC005484
    Conserved Domains (1) summary
    cl17037
    Location:39 → 377
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    73955329..74019288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    68162983..68226953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75356.1 GenPept UniProtKB/Swiss-Prot:O75356

Gene LinkOut

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