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KIF20B kinesin family member 20B [ Homo sapiens (human) ]

Gene ID: 9585, updated on 2-Nov-2024

Summary

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Official Symbol
KIF20Bprovided by HGNC
Official Full Name
kinesin family member 20Bprovided by HGNC
Primary source
HGNC:HGNC:7212
See related
Ensembl:ENSG00000138182 MIM:605498; AllianceGenome:HGNC:7212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT90; MPP1; KRMP1; MPP-1; MPHOSPH1
Summary
Enables several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 5.3), lymph node (RPKM 5.3) and 24 other tissues See more
Orthologs
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Genomic context

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See KIF20B in Genome Data Viewer
Location:
10q23.31
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (89701590..89774934)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (90585487..90658826)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91461347..91534691)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene pantothenate kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2594 Neighboring gene PANK1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr10:91453141-91453642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2595 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:91460993-91461508 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:91461509-91462025 Neighboring gene tigger transposable element derived 2 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr10:91500841-91501342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2596 Neighboring gene MT-ND5 pseudogene 42 Neighboring gene uncharacterized LOC105378424 Neighboring gene long intergenic non-protein coding RNA 865

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer. Mbugua RW, et al. Int J Oncol, 2024 Apr. PMID 38426627
  2. Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1). Fritzler MJ, et al. J Investig Med, 2000 Jan. PMID 10695267
  3. Kinesin-6 KIF20B is required for efficient cytokinetic furrowing and timely abscission in human cells. Janisch KM, et al. Mol Biol Cell, 2018 Jan 15. PMID 29167382, Free PMC Article
  4. Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation. Li ZY, et al. Mol Med Rep, 2019 Mar. PMID 30664160, Free PMC Article
  5. KIF20B Correlates with LUAD Progression and Is an Independent Risk Factor. Yang J, et al. Crit Rev Eukaryot Gene Expr, 2024. PMID 38305288

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF20B Correlates with LUAD Progression and Is an Independent Risk Factor.
    Title: KIF20B Correlates with LUAD Progression and Is an Independent Risk Factor.
  2. Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer.
    Title: Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer.
  3. USP7 Regulates Cytokinesis through FBXO38 and KIF20B.
    Title: USP7 Regulates Cytokinesis through FBXO38 and KIF20B.
  4. the high level of KIF20B in oral squamous cell carcinoma was significantly associated with poor clinicopathological features and survival. KIF20B might promote cancer development through enhancing cell proliferation in vitro, and might be a potential biomarker of oral squamous cell carcinoma.
    Title: Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation.
  5. KIF20B may be a potential biomarker and promising treatment target for CRC.
    Title: Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.
  6. KIF20B has a cell-autonomous role in cytokinesis. KIF20B depletion affects the speed of both furrow ingression and abscission. It localizes to microtubules of the central spindle and midbody throughout cytokinesis, at sites distinct from the other Kinesin-6 family members.
    Title: Kinesin-6 KIF20B is required for efficient cytokinetic furrowing and timely abscission in human cells.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
  8. MPP1 is a new mitotic molecular motor required for completion of cytokinesis
    Title: M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434B0435, DKFZp434P0810

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables WW domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitotic cytokinetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic nuclear division NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle midzone ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF20B
Names
M-phase phosphoprotein 1
cancer/testis antigen 90
kinesin-related motor interacting with PIN1
mitotic kinesin-like protein
mitotic kinesin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284259.2 → NP_001271188.1  kinesin-like protein KIF20B isoform 1

    See identical proteins and their annotated locations for NP_001271188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL157389, AL157400
    Consensus CDS
    CCDS60590.1
    UniProtKB/Swiss-Prot
    A8MXM7, O43277, Q09471, Q2KQ73, Q32NE1, Q561V3, Q58EX8, Q5T9M8, Q5T9M9, Q5T9N0, Q5T9N1, Q7KZ68, Q7Z5E0, Q7Z5E1, Q7Z6M9, Q86X82, Q96Q89, Q9H3R8, Q9H6Q9, Q9H755, Q9NTC1, Q9UFR5
    Related
    ENSP00000360793.3, ENST00000371728.8
    Conserved Domains (4) summary
    COG1196
    Location:629 → 1455
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01368
    Location:57 → 477
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:64 → 479
    Kinesin; Kinesin motor domain
    cl19219
    Location:1268 → 1357
    DUF342; Protein of unknown function (DUF342)

  2. NM_001382506.1 → NP_001369435.1  kinesin-like protein KIF20B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL157389, AL157400
    Conserved Domains (4) summary
    COG1196
    Location:558 → 1361
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:1430 → 1716
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd01368
    Location:57 → 406
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    cd21786
    Location:529 → 583
    RBD_KIF20B; RAB6 binding domain (RBD) found in kinesin-like protein KIF20B, and similar proteins

  3. NM_016195.4 → NP_057279.2  kinesin-like protein KIF20B isoform 2

    See identical proteins and their annotated locations for NP_057279.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to isoform 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AL157389, AL157400
    Consensus CDS
    CCDS7407.1
    Related
    ENSP00000260753.4, ENST00000260753.8
    Conserved Domains (4) summary
    COG1196
    Location:673 → 1392
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01368
    Location:57 → 477
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:64 → 479
    Kinesin; Kinesin motor domain
    cl19219
    Location:1228 → 1317
    DUF342; Protein of unknown function (DUF342)

RNA

  1. NR_168374.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157389, AL157400

  2. NR_168375.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL157389, AL157400

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    89701590..89774934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    90585487..90658826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96Q89.3 GenPept UniProtKB/Swiss-Prot:Q96Q89

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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