U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TESMIN testis expressed metallothionein like protein [ Homo sapiens (human) ]

Gene ID: 9633, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TESMINprovided by HGNC
Official Full Name
testis expressed metallothionein like proteinprovided by HGNC
Primary source
HGNC:HGNC:7446
See related
Ensembl:ENSG00000132749 MIM:604374; AllianceGenome:HGNC:7446
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTL5; MTLT; CXCDC2
Summary
Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 13.9), bone marrow (RPKM 1.4) and 2 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11q13.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (68704796..68751520, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (68710920..68757642, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68474908..68518988, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68278329-68278907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68278908-68279485 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:68307752-68308457 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68310718-68311218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68311219-68311719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68351250-68351750 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:68370649-68370853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68376961-68377462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68377463-68377962 Neighboring gene NANOG hESC enhancer GRCh37_chr11:68390073-68390603 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:68399697-68400286 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:68400287-68400875 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:68400876-68401464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68419596-68420268 Neighboring gene uncharacterized LOC107984343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68450731-68451406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68452083-68452758 Neighboring gene Sharpr-MPRA regulatory region 1260 Neighboring gene NANOG hESC enhancer GRCh37_chr11:68462220-68462721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68474187-68474945 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68479758-68480258 Neighboring gene galanin and GMAP prepropeptide Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68518115-68519100 Neighboring gene uncharacterized LOC124902699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68531008-68531810 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:68549035-68550234 Neighboring gene carnitine palmitoyltransferase 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68565881-68566380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68609778-68610303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5144 Neighboring gene uncharacterized LOC124902700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3685

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma. Huang Y, et al. Bioengineered, 2022 Mar. PMID 35249447, Free PMC Article
  2. Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes. Matsuura T, et al. J Inorg Biochem, 2002 Jan 15. PMID 11803038
  3. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. Sugihara T, et al. Genomics, 1999 Apr 1. PMID 10191092
  4. Native tesmin is a 60-kilodalton protein that undergoes dynamic changes in its localization during spermatogenesis in mice. Sutou S, et al. Biol Reprod, 2003 May. PMID 12606435
  5. Tesmin transcription is regulated differently during male and female meiosis. Olesen C, et al. Mol Reprod Dev, 2004 Jan. PMID 14648882

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical Significance and Functional Insights of Tesmin in Hepatocellular Carcinoma.
    Title: Clinical Significance and Functional Insights of Tesmin in Hepatocellular Carcinoma.
  2. Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.
    Title: Metallothionein-like 5 expression is correlated with poor prognosis and promotes proliferation of cervical squamous cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular monoatomic cation homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in male meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to metal ion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tesmin
Names
CXC domain containing 2
metallothionein-like 5, testis-specific (tesmin)
testis-specific metallothionein-like protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039656.1 → NP_001034745.1  tesmin isoform b

    See identical proteins and their annotated locations for NP_001034745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the C-terminus compared to isoform a.
    Source sequence(s)
    AP003096, BC027593, BM790577
    Consensus CDS
    CCDS44661.1
    UniProtKB/Swiss-Prot
    Q9Y4I5
    Related
    ENSP00000440968.1, ENST00000544963.1

  2. NM_004923.3 → NP_004914.2  tesmin isoform a

    See identical proteins and their annotated locations for NP_004914.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    BC064579, BM790577
    Consensus CDS
    CCDS8184.1
    UniProtKB/Swiss-Prot
    A8K8J3, Q4G182, Q6P2E2, Q8NCC8, Q9Y4I5
    Related
    ENSP00000255087.5, ENST00000255087.10
    Conserved Domains (1) summary
    pfam03638
    Location:367 → 404
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    68704796..68751520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018588.2 → XP_016874077.1  tesmin isoform X2

  2. XM_011545402.2 → XP_011543704.1  tesmin isoform X1

    See identical proteins and their annotated locations for XP_011543704.1

    Conserved Domains (1) summary
    pfam03638
    Location:367 → 404
    TCR; Tesmin/TSO1-like CXC domain, cysteine-rich domain

  3. XM_047427921.1 → XP_047283877.1  tesmin isoform X3

  4. XM_047427924.1 → XP_047283880.1  tesmin isoform X6

  5. XM_047427923.1 → XP_047283879.1  tesmin isoform X5

  6. XM_047427922.1 → XP_047283878.1  tesmin isoform X4

RNA

  1. XR_007062529.1 RNA Sequence

  2. XR_007062530.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    68710920..68757642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370606.1 → XP_054226581.1  tesmin isoform X2

  2. XM_054370605.1 → XP_054226580.1  tesmin isoform X1

  3. XM_054370607.1 → XP_054226582.1  tesmin isoform X3

  4. XM_054370610.1 → XP_054226585.1  tesmin isoform X6

  5. XM_054370609.1 → XP_054226584.1  tesmin isoform X5

  6. XM_054370608.1 → XP_054226583.1  tesmin isoform X4

RNA

  1. XR_008488496.1 RNA Sequence

  2. XR_008488497.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y4I5.2 GenPept UniProtKB/Swiss-Prot:Q9Y4I5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous