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CD70 CD70 molecule [ Homo sapiens (human) ]

Gene ID: 970, updated on 1-Mar-2024

Summary

Official Symbol
CD70provided by HGNC
Official Full Name
CD70 moleculeprovided by HGNC
Primary source
HGNC:HGNC:11937
See related
Ensembl:ENSG00000125726 MIM:602840; AllianceGenome:HGNC:11937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD27L; LPFS3; CD27-L; CD27LG; TNFSF7; TNLG8A
Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CD70 in Genome Data Viewer
Location:
19p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6581648..6591150, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6571316..6593751, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6581659..6591161, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13841 Neighboring gene TGFBR1 pseudogene 1 Neighboring gene MPRA-validated peak3304 silencer Neighboring gene chloride intracellular channel 4 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6577143-6577827 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6579197-6579879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6585724-6586478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6586479-6587231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13849 Neighboring gene ribosomal protein L7 pseudogene 50 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6631163-6631664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13857 Neighboring gene TNF superfamily member 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CD70 antigen
Names
CD27 ligand
Ki-24 antigen
surface antigen CD70
tumor necrosis factor ligand 8A
tumor necrosis factor ligand superfamily member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252.5NP_001243.1  CD70 antigen isoform 1

    See identical proteins and their annotated locations for NP_001243.1

    Status: REVIEWED

    Source sequence(s)
    AC008760, KC877696
    Consensus CDS
    CCDS12170.1
    UniProtKB/Swiss-Prot
    B4DPR8, P32970, Q53XX4, Q96J57
    UniProtKB/TrEMBL
    A0A0U5JA32
    Related
    ENSP00000245903.2, ENST00000245903.4
    Conserved Domains (1) summary
    smart00207
    Location:73191
    TNF; Tumour necrosis factor family
  2. NM_001330332.2NP_001317261.1  CD70 antigen isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC008760, AK298467
    Consensus CDS
    CCDS82283.1
    UniProtKB/Swiss-Prot
    P32970
    Related
    ENSP00000395294.2, ENST00000423145.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    6581648..6591150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    6571316..6593751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322747.1XP_054178722.1  CD70 antigen isoform X1

    UniProtKB/Swiss-Prot
    B4DPR8, P32970, Q53XX4, Q96J57
    UniProtKB/TrEMBL
    A0A0U5JA32
  2. XM_054322748.1XP_054178723.1  CD70 antigen isoform X1

    UniProtKB/Swiss-Prot
    B4DPR8, P32970, Q53XX4, Q96J57
    UniProtKB/TrEMBL
    A0A0U5JA32