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Nhsl3 NHS like 3 [ Mus musculus (house mouse) ]

Gene ID: 97130, updated on 2-Nov-2024

Summary

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Official Symbol
Nhsl3provided by MGI
Official Full Name
NHS like 3provided by MGI
Primary source
MGI:MGI:2140651
See related
Ensembl:ENSMUSG00000050390 AllianceGenome:MGI:2140651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C77080; mKIAA1522
Summary
Predicted to be involved in cell differentiation. Orthologous to human NHSL3 (NHS like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 89.1), duodenum adult (RPKM 85.4) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Nhsl3 in Genome Data Viewer
Location:
4 D2.2; 4 63.11 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129113371..129155194, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129219578..129261404, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene S100P binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3517 Neighboring gene STARR-seq mESC enhancer starr_11478 Neighboring gene tyrosyl-tRNA synthetase 1 Neighboring gene STARR-seq mESC enhancer starr_11480 Neighboring gene STARR-seq mESC enhancer starr_11482 Neighboring gene predicted gene 12976 Neighboring gene STARR-positive B cell enhancer ABC_E7991 Neighboring gene syncoilin Neighboring gene retinoblastoma binding protein 4, chromatin remodeling factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129012802-129012911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129013051-129013391 Neighboring gene zinc finger and BTB domain containing 8 opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
  2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
NHS-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033189.4 → NP_001028361.1  NHS-like protein 3 isoform a

    See identical proteins and their annotated locations for NP_001028361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS18686.1
    UniProtKB/Swiss-Prot
    A2A7S8
    Related
    ENSMUSP00000062395.6, ENSMUST00000052602.6
    Conserved Domains (1) summary
    PRK14951
    Location:847 → 1006
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

  2. NM_001285865.2 → NP_001272794.1  NHS-like protein 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS71475.1
    UniProtKB/Swiss-Prot
    A2A7S8
    Related
    ENSMUSP00000095483.4, ENSMUST00000097873.10
    Conserved Domains (1) summary
    PRK14951
    Location:802 → 961
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

  3. NM_001285866.2 → NP_001272795.1  NHS-like protein 3 isoform c

    See identical proteins and their annotated locations for NP_001272795.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS71474.1
    UniProtKB/Swiss-Prot
    A2A7S8, A2A7S9, Q3U356, Q3U437, Q3V3N0, Q6ZPN9, Q8K0K8
    Related
    ENSMUSP00000101666.2, ENSMUST00000106051.8
    Conserved Domains (1) summary
    PRK14951
    Location:790 → 949
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

  4. NM_001285867.2 → NP_001272796.1  NHS-like protein 3 isoform d

    See identical proteins and their annotated locations for NP_001272796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL606977, AL607123
    UniProtKB/Swiss-Prot
    A2A7S8
    Conserved Domains (1) summary
    PRK14951
    Location:677 → 836
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129113371..129155194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A7S8.1 GenPept UniProtKB/Swiss-Prot:A2A7S8

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