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ZNF646 zinc finger protein 646 [ Homo sapiens (human) ]

Gene ID: 9726, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF646provided by HGNC
Official Full Name
zinc finger protein 646provided by HGNC
Primary source
HGNC:HGNC:29004
See related
Ensembl:ENSG00000167395 MIM:619299; AllianceGenome:HGNC:29004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 13.8), spleen (RPKM 4.2) and 23 other tissues See more
Orthologs
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Genomic context

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See ZNF646 in Genome Data Viewer
Location:
16p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31072687..31084196)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31460383..31471624)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31085743..31095517)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31001361-31002004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31002005-31002648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7407 Neighboring gene syntaxin 1B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31011808-31012308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31012309-31012809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31021995-31022496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31044203-31044714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31045227-31045737 Neighboring gene syntaxin 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31074971-31075598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31075599-31076226 Neighboring gene zinc finger protein 668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31084437-31085237 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31085443-31085976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31085977-31086509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31099941-31100441 Neighboring gene serine protease 53 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31104343-31105051 Neighboring gene zinc finger protein ENSP00000375192-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10748 Neighboring gene vitamin K epoxide reductase complex subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 646

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014699.4 → NP_055514.3  zinc finger protein 646

    See identical proteins and their annotated locations for NP_055514.3

    Status: VALIDATED

    Source sequence(s)
    AC135050, BC035589
    Consensus CDS
    CCDS10702.1
    UniProtKB/Swiss-Prot
    O15015, Q8IVD8
    Related
    ENSP00000300850.5, ENST00000300850.5
    Conserved Domains (3) summary
    sd00017
    Location:1232 → 1252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:75 → 97
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1718 → 1743
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    31072687..31084196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434956.1 → XP_047290912.1  zinc finger protein 646 isoform X1

    UniProtKB/Swiss-Prot
    O15015, Q8IVD8

  2. XM_011545990.3 → XP_011544292.1  zinc finger protein 646 isoform X1

    See identical proteins and their annotated locations for XP_011544292.1

    UniProtKB/Swiss-Prot
    O15015, Q8IVD8
    Conserved Domains (3) summary
    sd00017
    Location:1232 → 1252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:75 → 97
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1718 → 1743
    zf-H2C2_2; Zinc-finger double domain

  3. XM_005255712.5 → XP_005255769.1  zinc finger protein 646 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:222 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1232 → 1252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1718 → 1743
    zf-H2C2_2; Zinc-finger double domain

  4. XM_005255710.5 → XP_005255767.1  zinc finger protein 646 isoform X1

    See identical proteins and their annotated locations for XP_005255767.1

    UniProtKB/Swiss-Prot
    O15015, Q8IVD8
    Conserved Domains (3) summary
    sd00017
    Location:1232 → 1252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:75 → 97
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1718 → 1743
    zf-H2C2_2; Zinc-finger double domain

  5. XM_047434957.1 → XP_047290913.1  zinc finger protein 646 isoform X2

  6. XM_005255711.5 → XP_005255768.1  zinc finger protein 646 isoform X1

    See identical proteins and their annotated locations for XP_005255768.1

    UniProtKB/Swiss-Prot
    O15015, Q8IVD8
    Conserved Domains (3) summary
    sd00017
    Location:1232 → 1252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:75 → 97
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1718 → 1743
    zf-H2C2_2; Zinc-finger double domain

  7. XM_047434958.1 → XP_047290914.1  zinc finger protein 646 isoform X2

RNA

  1. XR_001752041.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    31460383..31471624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314489.1 → XP_054170464.1  zinc finger protein 646 isoform X1

    UniProtKB/Swiss-Prot
    O15015, Q8IVD8

  2. XM_054314491.1 → XP_054170466.1  zinc finger protein 646 isoform X2

  3. XM_054314488.1 → XP_054170463.1  zinc finger protein 646 isoform X1

    UniProtKB/Swiss-Prot
    O15015, Q8IVD8

  4. XM_054314492.1 → XP_054170467.1  zinc finger protein 646 isoform X2

  5. XM_054314490.1 → XP_054170465.1  zinc finger protein 646 isoform X1

    UniProtKB/Swiss-Prot
    O15015, Q8IVD8

  6. XM_054314493.1 → XP_054170468.1  zinc finger protein 646 isoform X2

RNA

  1. XR_008484753.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15015.2 GenPept UniProtKB/Swiss-Prot:O15015

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