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KIAA0408 KIAA0408 [ Homo sapiens (human) ]

Gene ID: 9729, updated on 5-Mar-2024

Summary

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Official Symbol
KIAA0408provided by HGNC
Official Full Name
KIAA0408provided by HGNC
Primary source
HGNC:HGNC:21636
See related
Ensembl:ENSG00000189367 MIM:619236; AllianceGenome:HGNC:21636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 13.3), fat (RPKM 8.5) and 14 other tissues See more
Orthologs
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Genomic context

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Location:
6q22.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (127438406..127459389, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (128627332..128648316, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (127759551..127780534, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cornichon family AMPA receptor auxiliary protein 4 pseudogene Neighboring gene SOGA3-KIAA0408 readthrough Neighboring gene ribosomal protein L17 pseudogene 23 Neighboring gene uncharacterized LOC124901399 Neighboring gene Sharpr-MPRA regulatory region 7566 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:127802337-127803536 Neighboring gene MTCL family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25041 Neighboring gene uncharacterized LOC107986642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:127835952-127836476

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. Ishikawa K, et al. DNA Res, 1997 Oct 31. PMID 9455477
  2. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677
  3. A comprehensive resource of interacting protein regions for refining human transcription factor networks. Miyamoto-Sato E, et al. PLoS One, 2010 Feb 24. PMID 20195357, Free PMC Article
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL, et al. Hum Mol Genet, 2014 Aug 1. PMID 24705354, Free PMC Article
  5. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. Yeung ML, et al. J Biol Chem, 2009 Jul 17. PMID 19460752, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of uncharacterized protein KIAA0408 by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough SOGA3-KIAA0408

Readthrough gene: SOGA3-KIAA0408, Included gene: MTCL3

Homology

Clone Names

  • FLJ43995

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein KIAA0408

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014702.5 → NP_055517.3  uncharacterized protein KIAA0408

    See identical proteins and their annotated locations for NP_055517.3

    Status: VALIDATED

    Source sequence(s)
    AK125983, AL096711, AL596809
    Consensus CDS
    CCDS34531.1
    UniProtKB/Swiss-Prot
    B3KRE5, E1P573, O43158, Q5TF20, Q6ZU52, Q7L2M2
    Related
    ENSP00000435150.2, ENST00000483725.8
    Conserved Domains (1) summary
    pfam14818
    Location:1 → 139
    DUF4482; Domain of unknown function (DUF4482)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    127438406..127459389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    128627332..128648316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZU52.1 GenPept UniProtKB/Swiss-Prot:Q6ZU52

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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