U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LZTS3 leucine zipper tumor suppressor family member 3 [ Homo sapiens (human) ]

Gene ID: 9762, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
LZTS3provided by HGNC
Official Full Name
leucine zipper tumor suppressor family member 3provided by HGNC
Primary source
HGNC:HGNC:30139
See related
Ensembl:ENSG00000088899 MIM:610484; AllianceGenome:HGNC:30139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PROSAPIP1
Summary
Predicted to enable PDZ domain binding activity and protein self-association. Predicted to be involved in protein homooligomerization and regulation of dendritic spine morphogenesis. Predicted to be located in postsynaptic density. Predicted to be active in dendritic spine. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 17.2), kidney (RPKM 9.1) and 19 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LZTS3 in Genome Data Viewer
Location:
20p13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3162617..3173549, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3193522..3204462, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3143263..3154195, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 555, pseudogene Neighboring gene UBOX5 antisense RNA 1 Neighboring gene U-box domain containing 5 Neighboring gene FAST kinase domains 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12614 Neighboring gene uncharacterized LOC107985414 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:3163335-3163502 Neighboring gene DDRGK domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3183418-3184016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17476 Neighboring gene inosine triphosphatase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. In silico characterization of LZTS3, a potential tumor suppressor. Teufel A, et al. Oncol Rep, 2005 Aug. PMID 16012743
  2. Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275. Feng J, et al. Bioengineered, 2021 Dec. PMID 33315502, Free PMC Article
  3. Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies. Grabrucker AM, et al. Trends Cell Biol, 2011 Oct. PMID 21840719
  4. ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. Wendholt D, et al. J Biol Chem, 2006 May 12. PMID 16522626
  5. Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders. Li J, et al. Cell Syst, 2015 Nov 25. PMID 26949739, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LZTS3/TAGLN Suppresses Cancer Progression in Human Colorectal Adenocarcinoma Through Regulating Cell Proliferation, Migration, and Actin Cytoskeleton.
    Title: LZTS3/TAGLN Suppresses Cancer Progression in Human Colorectal Adenocarcinoma Through Regulating Cell Proliferation, Migration, and Actin Cytoskeleton.
  2. Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275.
    Title: Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275.
  3. We thus propose a model where ProSAP/Shank proteins are in the center of a postsynaptic signaling pathway that is disrupted in several neuropsychiatric disorders.
    Title: Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA0552, RP5-1187M17.10

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
leucine zipper putative tumor suppressor 3
Names
ProSAP/Shank-interacting protein 1
leucine zipper, putative tumor suppressor family member 3
proline rich synapse associated protein interacting protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282533.2 → NP_001269462.1  leucine zipper putative tumor suppressor 3 isoform 2

    See identical proteins and their annotated locations for NP_001269462.1

    Status: VALIDATED

    Source sequence(s)
    AB011124, AL121891, BC038860, BU684906, HY126776
    Consensus CDS
    CCDS63218.1
    UniProtKB/Swiss-Prot
    O60299
    Related
    ENSP00000353496.3, ENST00000360342.7
    Conserved Domains (2) summary
    pfam06818
    Location:392 → 591
    Fez1; Fez1
    cl25742
    Location:322 → 451
    ERM; Ezrin/radixin/moesin family

  2. NM_001365618.1 → NP_001352547.1  leucine zipper putative tumor suppressor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Consensus CDS
    CCDS13049.1
    UniProtKB/Swiss-Prot
    A2A2Q7, D3DVX6, O60299, Q8IXX8
    Related
    ENSP00000338166.6, ENST00000337576.7
    Conserved Domains (2) summary
    COG1196
    Location:318 → 515
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:438 → 638
    Fez1

  3. NM_001367609.1 → NP_001354538.1  leucine zipper putative tumor suppressor 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Conserved Domains (2) summary
    COG1196
    Location:348 → 545
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:468 → 668
    Fez1

  4. NM_001388189.1 → NP_001375118.1  leucine zipper putative tumor suppressor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Consensus CDS
    CCDS13049.1
    UniProtKB/Swiss-Prot
    A2A2Q7, D3DVX6, O60299, Q8IXX8
    Conserved Domains (2) summary
    COG1196
    Location:318 → 515
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:438 → 638
    Fez1

  5. NM_001388190.1 → NP_001375119.1  leucine zipper putative tumor suppressor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Consensus CDS
    CCDS13049.1
    UniProtKB/Swiss-Prot
    A2A2Q7, D3DVX6, O60299, Q8IXX8
    Conserved Domains (2) summary
    COG1196
    Location:318 → 515
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:438 → 638
    Fez1

  6. NM_001388191.1 → NP_001375120.1  leucine zipper putative tumor suppressor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Consensus CDS
    CCDS13049.1
    UniProtKB/Swiss-Prot
    A2A2Q7, D3DVX6, O60299, Q8IXX8
    Related
    ENSP00000332123.3, ENST00000329152.7
    Conserved Domains (2) summary
    COG1196
    Location:318 → 515
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:438 → 638
    Fez1

  7. NM_001388192.1 → NP_001375121.1  leucine zipper putative tumor suppressor 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Conserved Domains (2) summary
    COG1196
    Location:348 → 524
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:451 → 647
    Fez1

  8. NM_001388193.1 → NP_001375122.1  leucine zipper putative tumor suppressor 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Conserved Domains (2) summary
    COG1196
    Location:318 → 494
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:421 → 617
    Fez1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    3162617..3173549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529408.4 → XP_011527710.1  leucine zipper putative tumor suppressor 3 isoform X1

    See identical proteins and their annotated locations for XP_011527710.1

    Conserved Domains (2) summary
    COG1196
    Location:348 → 545
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:468 → 668
    Fez1

  2. XM_011529409.4 → XP_011527711.1  leucine zipper putative tumor suppressor 3 isoform X1

    See identical proteins and their annotated locations for XP_011527711.1

    Conserved Domains (2) summary
    COG1196
    Location:348 → 545
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:468 → 668
    Fez1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    3193522..3204462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324275.1 → XP_054180250.1  leucine zipper putative tumor suppressor 3 isoform X2

  2. XM_054324273.1 → XP_054180248.1  leucine zipper putative tumor suppressor 3 isoform X1

  3. XM_054324277.1 → XP_054180252.1  leucine zipper putative tumor suppressor 3 isoform X3

    UniProtKB/Swiss-Prot
    A2A2Q7, D3DVX6, O60299, Q8IXX8

  4. XM_054324276.1 → XP_054180251.1  leucine zipper putative tumor suppressor 3 isoform X3

    UniProtKB/Swiss-Prot
    A2A2Q7, D3DVX6, O60299, Q8IXX8

  5. XM_054324274.1 → XP_054180249.1  leucine zipper putative tumor suppressor 3 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014731.2: Suppressed sequence

    Description
    NM_014731.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60299.1 GenPept UniProtKB/Swiss-Prot:O60299

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous