U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DLGAP5 DLG associated protein 5 [ Homo sapiens (human) ]

Gene ID: 9787, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
DLGAP5provided by HGNC
Official Full Name
DLG associated protein 5provided by HGNC
Primary source
HGNC:HGNC:16864
See related
Ensembl:ENSG00000126787 MIM:617859; AllianceGenome:HGNC:16864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLG7; HURP
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in several cellular components, including centrosome; cytosol; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 9.4), testis (RPKM 9.1) and 12 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
14q22.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55148135..55191585, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49353325..49396782, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55614853..55658303, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8427 Neighboring gene Sharpr-MPRA regulatory region 5571 Neighboring gene galectin 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:55657493-55658046 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:55658047-55658599 Neighboring gene uncharacterized LOC105370508 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:55662229-55662728 Neighboring gene uncharacterized LOC107984708

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. High Expression of DLGAP5 Indicates Poor Prognosis and Immunotherapy in Lung Adenocarcinoma and Promotes Proliferation through Regulation of the Cell Cycle. Tang X, et al. Dis Markers, 2023. PMID 36712920, Free PMC Article
  2. DLGAP5 knockdown inactivates the Wnt/β-catenin signal to repress endometrial cancer cell malignant activities. Chen R, et al. Environ Toxicol, 2023 Mar. PMID 36454672
  3. Whole Genome Transcriptomic Analysis of Ovary Granulosa Cells Revealed an Anti-Apoptosis Regulatory Gene DLGAP5 in Polycystic Ovary Syndrome. Deng Y, et al. Front Endocrinol (Lausanne), 2022. PMID 35370991, Free PMC Article
  4. Pan-cancer analysis and experiments with cell lines reveal that the slightly elevated expression of DLGAP5 is involved in clear cell renal cell carcinoma progression. Feng Y, et al. Life Sci, 2021 Dec 15. PMID 34687756
  5. The expression of hepatoma upregulated protein in human endometrium during the menstrual cycle. Takahashi A, et al. Gynecol Endocrinol, 2021 Feb. PMID 32840162

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1 and serves as a therapeutic target.
    Title: DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1 and serves as a therapeutic target.
  2. DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11.
    Title: DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11.
  3. circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557.
    Title: circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557.
  4. DLGAP5 promotes gallbladder cancer migration and tumor-associated macrophage M2 polarization by activating cAMP.
    Title: DLGAP5 promotes gallbladder cancer migration and tumor-associated macrophage M2 polarization by activating cAMP.
  5. DLGAP5 knockdown inactivates the Wnt/beta-catenin signal to repress endometrial cancer cell malignant activities.
    Title: DLGAP5 knockdown inactivates the Wnt/β-catenin signal to repress endometrial cancer cell malignant activities.
  6. High Expression of DLGAP5 Indicates Poor Prognosis and Immunotherapy in Lung Adenocarcinoma and Promotes Proliferation through Regulation of the Cell Cycle.
    Title: High Expression of DLGAP5 Indicates Poor Prognosis and Immunotherapy in Lung Adenocarcinoma and Promotes Proliferation through Regulation of the Cell Cycle.
  7. Whole Genome Transcriptomic Analysis of Ovary Granulosa Cells Revealed an Anti-Apoptosis Regulatory Gene DLGAP5 in Polycystic Ovary Syndrome.
    Title: Whole Genome Transcriptomic Analysis of Ovary Granulosa Cells Revealed an Anti-Apoptosis Regulatory Gene DLGAP5 in Polycystic Ovary Syndrome.
  8. Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas.
    Title: Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas.
  9. Pan-cancer analysis and experiments with cell lines reveal that the slightly elevated expression of DLGAP5 is involved in clear cell renal cell carcinoma progression.
    Title: Pan-cancer analysis and experiments with cell lines reveal that the slightly elevated expression of DLGAP5 is involved in clear cell renal cell carcinoma progression.
  10. The expression of hepatoma upregulated protein in human endometrium during the menstrual cycle.
    Title: The expression of hepatoma upregulated protein in human endometrium during the menstrual cycle.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of circulating galectin-3.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA0008

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic chromosome movement towards spindle pole NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
disks large-associated protein 5
Names
DAP-5
discs large homolog associated protein 5
discs, large homolog 7
disks large-associated protein DLG7
hepatoma up-regulated protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146015.2 → NP_001139487.1  disks large-associated protein 5 isoform b

    See identical proteins and their annotated locations for NP_001139487.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform b) has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK299338, BM788630, BX248255
    Consensus CDS
    CCDS53897.1
    UniProtKB/TrEMBL
    A8K732
    Related
    ENSP00000378815.2, ENST00000395425.6
    Conserved Domains (1) summary
    pfam03359
    Location:432 → 599
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. NM_014750.5 → NP_055565.3  disks large-associated protein 5 isoform a

    See identical proteins and their annotated locations for NP_055565.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AB076695, BC010658
    Consensus CDS
    CCDS9723.1
    UniProtKB/Swiss-Prot
    A8MTM6, B4DRM8, Q15398, Q86T11, Q8NG58
    UniProtKB/TrEMBL
    A8K732
    Related
    ENSP00000247191.2, ENST00000247191.7
    Conserved Domains (1) summary
    pfam03359
    Location:432 → 599
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    55148135..55191585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021840.3 → XP_016877329.1  disks large-associated protein 5 isoform X1

    UniProtKB/Swiss-Prot
    A8MTM6, B4DRM8, Q15398, Q86T11, Q8NG58
    UniProtKB/TrEMBL
    A8K732
    Conserved Domains (1) summary
    pfam03359
    Location:432 → 599
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. XM_047432016.1 → XP_047287972.1  disks large-associated protein 5 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    49353325..49396782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377137.1 → XP_054233112.1  disks large-associated protein 5 isoform X1

    UniProtKB/Swiss-Prot
    A8MTM6, B4DRM8, Q15398, Q86T11, Q8NG58

  2. XM_054377138.1 → XP_054233113.1  disks large-associated protein 5 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15398.2 GenPept UniProtKB/Swiss-Prot:Q15398

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous