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Deptor DEP domain containing MTOR-interacting protein [ Mus musculus (house mouse) ]

Gene ID: 97998, updated on 2-Nov-2024

Summary

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Official Symbol
Deptorprovided by MGI
Official Full Name
DEP domain containing MTOR-interacting proteinprovided by MGI
Primary source
MGI:MGI:2146322
See related
Ensembl:ENSMUSG00000022419 AllianceGenome:MGI:2146322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Depdc6
Summary
Predicted to enable phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Predicted to be active in lysosomal membrane. Is expressed in brain and lung. Orthologous to human DEPTOR (DEP domain containing MTOR interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 11.6), subcutaneous fat pad adult (RPKM 8.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Deptor in Genome Data Viewer
Location:
15 D1; 15 21.96 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54975824..55122667)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (55112317..55259273)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr15:54903568-54903869 Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene predicted gene, 41325 Neighboring gene STARR-positive B cell enhancer ABC_E3139 Neighboring gene predicted gene 9920 Neighboring gene predicted gene, 26296 Neighboring gene predicted gene, 35312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DEPTOR exacerbates bone-fat imbalance in osteoporosis by transcriptionally modulating BMSC differentiation. Ouyang Z, et al. Biomed Pharmacother, 2022 Jul. PMID 35609371
  2. DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance. Caron A, et al. Am J Physiol Regul Integr Comp Physiol, 2016 Jun 1. PMID 27097662, Free PMC Article
  3. DEPTOR Deficiency-Mediated mTORc1 Hyperactivation in Vascular Endothelial Cells Promotes Angiogenesis. Ding Y, et al. Cell Physiol Biochem, 2018. PMID 29614494
  4. DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis. Chen S, et al. Stem Cell Res Ther, 2018 Jul 4. PMID 29973283, Free PMC Article
  5. DEPTOR Prevents Osteoarthritis Development Via Interplay With TRC8 to Reduce Endoplasmic Reticulum Stress in Chondrocytes. Li K, et al. J Bone Miner Res, 2021 Feb. PMID 32916025

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells.
    Title: The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells.
  2. DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice.
    Title: DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice.
  3. High glucose-stimulated enhancer of zeste homolog-2 (EZH2) forces suppression of deptor to cause glomerular mesangial cell pathology.
    Title: High glucose-stimulated enhancer of zeste homolog-2 (EZH2) forces suppression of deptor to cause glomerular mesangial cell pathology.
  4. Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis.
    Title: Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis.
  5. miRNA-182/Deptor/mTOR axis regulates autophagy to reduce intestinal ischaemia/reperfusion injury.
    Title: miRNA-182/Deptor/mTOR axis regulates autophagy to reduce intestinal ischaemia/reperfusion injury.
  6. Helicobacter pylori promote inflammation and host defense through the cagA-dependent activation of mTORC1.
    Title: Helicobacter pylori promote inflammation and host defense through the cagA-dependent activation of mTORC1.
  7. DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals.
    Title: DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals.
  8. DEPTOR is a novel protein that functions in CD4(+) T cells to augment immunoregulation in vitro and in vivo
    Title: DEPTOR modulates activation responses in CD4(+) T cells and enhances immunoregulation following transplantation.
  9. findings demonstrate the roles and mechanisms of DEPTOR in the regulation of the renal physiology and pathology, and demonstrate that the loss of DEPTOR in the proximal tubules protects against cisplatin-induced acute kidney injury.
    Title: Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.
  10. Study revealed a novel function of DEPTOR in osteogenic differentiation by inhibiting MEG3-mediated activation of BMP4 signaling, which suggested that DEPTOR could be a therapeutic target for bone loss diseases and skeletal tissue regeneration.
    Title: DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (6)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4200

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC2 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC2 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell size IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
DEP domain-containing mTOR-interacting protein
Names
DEP domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037937.4 → NP_001033026.1  DEP domain-containing mTOR-interacting protein isoform b

    See identical proteins and their annotated locations for NP_001033026.1

    Status: VALIDATED

    Source sequence(s)
    AC124659
    Consensus CDS
    CCDS27475.1
    UniProtKB/TrEMBL
    B2ZRS7, B2ZRS8
    Related
    ENSMUSP00000023056.8, ENSMUST00000023056.8
    Conserved Domains (3) summary
    cd00992
    Location:327 → 391
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04441
    Location:121 → 205
    DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
    cl02442
    Location:29 → 105
    DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

  2. NM_145470.4 → NP_663445.2  DEP domain-containing mTOR-interacting protein isoform a

    See identical proteins and their annotated locations for NP_663445.2

    Status: VALIDATED

    Source sequence(s)
    AC124659
    Consensus CDS
    CCDS27474.1
    UniProtKB/Swiss-Prot
    Q3UM00, Q3UT08, Q570Y9
    UniProtKB/TrEMBL
    B2ZRS3, B2ZRS8
    Related
    ENSMUSP00000094167.4, ENSMUST00000096433.10
    Conserved Domains (3) summary
    cd00992
    Location:339 → 403
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04441
    Location:133 → 217
    DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
    cd04442
    Location:36 → 117
    DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    54975824..55122667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q570Y9.2 GenPept UniProtKB/Swiss-Prot:Q570Y9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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