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ELMO1 engulfment and cell motility 1 [ Homo sapiens (human) ]

Gene ID: 9844, updated on 5-Mar-2024

Summary

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Official Symbol
ELMO1provided by HGNC
Official Full Name
engulfment and cell motility 1provided by HGNC
Primary source
HGNC:HGNC:16286
See related
Ensembl:ENSG00000155849 MIM:606420; AllianceGenome:HGNC:16286
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CED12; CED-12; ELMO-1
Summary
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Broad expression in brain (RPKM 17.7), thyroid (RPKM 16.1) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See ELMO1 in Genome Data Viewer
Location:
7p14.2-p14.1
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (36852906..37449326, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (36993255..37589754, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (36892511..37488929, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36655105-36655606 Neighboring gene acyloxyacyl hydrolase Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:36693505-36694049 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:36701053-36701595 Neighboring gene AOAH intronic transcript 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:36802118-36803317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25844 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:36894293-36894794 Neighboring gene NANOG hESC enhancer GRCh37_chr7:36908573-36909127 Neighboring gene uncharacterized LOC105375235 Neighboring gene nucleophosmin 1 pseudogene 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25847 Neighboring gene MPRA-validated peak6484 silencer Neighboring gene Sharpr-MPRA regulatory region 8653 Neighboring gene microRNA 1200 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:37052330-37053529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25849 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:37071299-37072498 Neighboring gene ELMO1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25851 Neighboring gene NANOG hESC enhancer GRCh37_chr7:37156919-37157420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:37193283-37193902 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein S17 pseudogene 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25852 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:37243623-37244822 Neighboring gene origin-enriched sequence 8 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:37287752-37288372 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:37288373-37288992 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:37318405-37318906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:37318907-37319406 Neighboring gene Sharpr-MPRA regulatory region 7000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:37392751-37393252 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:37393979-37395178 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:37415805-37417004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25858 Neighboring gene RNA, U6 small nuclear 565, pseudogene Neighboring gene uncharacterized LOC124900242 Neighboring gene ribosomal protein S10 pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18103 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:37569874-37570374 Neighboring gene Sharpr-MPRA regulatory region 7218 Neighboring gene NECAP endocytosis associated 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25859 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:37745514-37745731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18106 Neighboring gene G protein-coupled receptor 141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Engulfment and cell motility protein 1 fosters reprogramming of tumor-associated macrophages in colorectal cancer. Wen B, et al. Cancer Sci, 2023 Feb. PMID 36310143, Free PMC Article
  2. Engulfment and Cell Motility 1 (ELMO1) Regulates Tumor Cell Behavior and Predicts Prognosis in Colorectal Cancer. Park YL, et al. Anticancer Res, 2022 Nov. PMID 36288887
  3. Role of ELMO1 in inflammation and cancer-clinical implications. Tocci S, et al. Cell Oncol (Dordr), 2022 Aug. PMID 35668246
  4. Association of ELMO1 gene polymorphism and diabetic nephropathy among Egyptian patients with type 2 diabetes mellitus. Bayoumy NMK, et al. Diabetes Metab Res Rev, 2020 Jul. PMID 32043290
  5. Association of single nucleotide polymorphism (rs741301) of the ELMO1 gene with diabetic kidney disease in Polish patients with type 2 diabetes: a pilot study. Kwiendacz H, et al. Endokrynol Pol, 2020. PMID 31909452

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis.
    Title: Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis.
  2. Engulfment and cell motility protein 1 fosters reprogramming of tumor-associated macrophages in colorectal cancer.
    Title: Engulfment and cell motility protein 1 fosters reprogramming of tumor-associated macrophages in colorectal cancer.
  3. Engulfment and Cell Motility 1 (ELMO1) Regulates Tumor Cell Behavior and Predicts Prognosis in Colorectal Cancer.
    Title: Engulfment and Cell Motility 1 (ELMO1) Regulates Tumor Cell Behavior and Predicts Prognosis in Colorectal Cancer.
  4. Role of ELMO1 in inflammation and cancer-clinical implications.
    Title: Role of ELMO1 in inflammation and cancer-clinical implications.
  5. The single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes.
    Title: The single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes.
  6. TNF-alpha-mediated m(6)A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis.
    Title: TNF-α-mediated m(6)A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis.
  7. Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy.
    Title: Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy.
  8. Association of ELMO1 gene polymorphism and diabetic nephropathy among Egyptian patients with type 2 diabetes mellitus.
    Title: Association of ELMO1 gene polymorphism and diabetic nephropathy among Egyptian patients with type 2 diabetes mellitus.
  9. ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.
    Title: ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.
  10. Association of single nucleotide polymorphism (rs741301) of the ELMO1 gene with diabetic kidney disease in Polish patients with type 2 diabetes: a pilot study.
    Title: Association of single nucleotide polymorphism (rs741301) of the ELMO1 gene with diabetic kidney disease in Polish patients with type 2 diabetes: a pilot study.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
EBI GWAS Catalog
A genome-wide association study of the Protein C anticoagulant pathway.
EBI GWAS Catalog
Genetic variants associated with breast size also influence breast cancer risk.
EBI GWAS Catalog
Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population.
EBI GWAS Catalog
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
EBI GWAS Catalog
Genome-wide association study of smoking behaviours in patients with COPD.
EBI GWAS Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
EBI GWAS Catalog
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef Interaction of HIV-1 Nef with a protein complex, which includes Rac2, DOCK2, and ELMO1, activates Rac activity in T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0281, MGC126406

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rac protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell motility IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phagocytosis, engulfment IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
engulfment and cell motility protein 1
Names
ced-12 homolog 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039459.3 → NP_001034548.1  engulfment and cell motility protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001034548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC007349, BC064635, BI600726
    Consensus CDS
    CCDS5450.1
    UniProtKB/Swiss-Prot
    Q92556
    Related
    ENSP00000379355.2, ENST00000396040.6
    Conserved Domains (1) summary
    cd13359
    Location:66 → 195
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

  2. NM_001206480.2 → NP_001193409.1  engulfment and cell motility protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001193409.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC007349, AF398885, AK314349, DA238090, DA312397
    Consensus CDS
    CCDS5449.1
    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5
    Related
    ENSP00000394458.1, ENST00000448602.5
    Conserved Domains (3) summary
    cd13359
    Location:546 → 675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 279
    DUF3361; Domain of unknown function (DUF3361)

  3. NM_001206482.2 → NP_001193411.1  engulfment and cell motility protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001193411.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AC007349, AK291784
    Consensus CDS
    CCDS5449.1
    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5
    Related
    ENSP00000406952.1, ENST00000442504.5
    Conserved Domains (3) summary
    cd13359
    Location:546 → 675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 279
    DUF3361; Domain of unknown function (DUF3361)

  4. NM_014800.11 → NP_055615.8  engulfment and cell motility protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055615.8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 4 and 5 encode the same isoform.
    Source sequence(s)
    AC007349, AC078843, AL136787
    Consensus CDS
    CCDS5449.1
    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5
    Related
    ENSP00000312185.4, ENST00000310758.9
    Conserved Domains (3) summary
    cd13359
    Location:546 → 675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 279
    DUF3361; Domain of unknown function (DUF3361)

  5. NM_130442.4 → NP_569709.1  engulfment and cell motility protein 1 isoform 2

    See identical proteins and their annotated locations for NP_569709.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC007349, BC077074, DC366992
    UniProtKB/Swiss-Prot
    Q92556
    Related
    ENSP00000379360.3, ENST00000396045.7
    Conserved Domains (1) summary
    cd13359
    Location:66 → 195
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

RNA

  1. NR_038120.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' exon structure and lacks an alternate internal exon compared to variant 1 and lacks an alternate internal exon compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007349, AK301151

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    36852906..37449326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515654.3 → XP_011513956.1  engulfment and cell motility protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011513956.1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5
    Conserved Domains (3) summary
    cd13359
    Location:546 → 675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 279
    DUF3361; Domain of unknown function (DUF3361)

  2. XM_005249919.4 → XP_005249976.1  engulfment and cell motility protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005249976.1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5
    Conserved Domains (3) summary
    cd13359
    Location:546 → 675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 279
    DUF3361; Domain of unknown function (DUF3361)

  3. XM_047421086.1 → XP_047277042.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  4. XM_047421087.1 → XP_047277043.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  5. XM_047421088.1 → XP_047277044.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  6. XM_024447008.2 → XP_024302776.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5
    Conserved Domains (3) summary
    cd13359
    Location:546 → 675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 279
    DUF3361; Domain of unknown function (DUF3361)

  7. XM_017012839.2 → XP_016868328.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5
    Conserved Domains (3) summary
    cd13359
    Location:546 → 675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 279
    DUF3361; Domain of unknown function (DUF3361)

  8. XM_006715805.2 → XP_006715868.1  engulfment and cell motility protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006715868.1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5
    Conserved Domains (3) summary
    cd13359
    Location:546 → 675
    PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
    pfam04727
    Location:303 → 481
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:116 → 279
    DUF3361; Domain of unknown function (DUF3361)

  9. XM_047421089.1 → XP_047277045.1  engulfment and cell motility protein 1 isoform X2

  10. XM_047421091.1 → XP_047277047.1  engulfment and cell motility protein 1 isoform X3

  11. XM_047421090.1 → XP_047277046.1  engulfment and cell motility protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    36993255..37589754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359429.1 → XP_054215404.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  2. XM_054359427.1 → XP_054215402.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  3. XM_054359426.1 → XP_054215401.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  4. XM_054359430.1 → XP_054215405.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  5. XM_054359431.1 → XP_054215406.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  6. XM_054359425.1 → XP_054215400.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  7. XM_054359428.1 → XP_054215403.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  8. XM_054359424.1 → XP_054215399.1  engulfment and cell motility protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4D1X6, Q29R79, Q6ZTJ0, Q92556, Q96PB0, Q9H0I1
    UniProtKB/TrEMBL
    A4D1X5

  9. XM_054359432.1 → XP_054215407.1  engulfment and cell motility protein 1 isoform X2

  10. XM_054359434.1 → XP_054215409.1  engulfment and cell motility protein 1 isoform X3

  11. XM_054359433.1 → XP_054215408.1  engulfment and cell motility protein 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92556.2 GenPept UniProtKB/Swiss-Prot:Q92556

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