TRIL TLR4 interactor with leucine rich repeats [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRILprovided by HGNC
Official Full Name: TLR4 interactor with leucine rich repeatsprovided by HGNC
Primary source: HGNC:HGNC:22200
See related: Ensembl:ENSG00000255690 MIM:613356; AllianceGenome:HGNC:22200
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010]
Orthologs: mouse all
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Genomic context

Location:: 7p14.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (28953358..28958330, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (29090882..29095853, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (28992974..28997946, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l.
Title: Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l.
Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL)
Title: Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).
Observational study of gene-disease association. (HuGE Navigator)
Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH45431 (e-PCR)
- UniSTS:67109

A004Y37 (e-PCR)
- UniSTS:38705

D3S1315 (e-PCR), detects polymorphism
- UniSTS:66129

RH91399 (e-PCR)
- UniSTS:88491

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of lipopolysaccharide receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of lipopolysaccharide receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TLR4 interactor with leucine rich repeats

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014817.4 → NP_055632.2 TLR4 interactor with leucine rich repeats precursor

See identical proteins and their annotated locations for NP_055632.2

Status: VALIDATED

Source sequence(s)

AC005013, BC036337

Consensus CDS

CCDS75573.1

UniProtKB/Swiss-Prot

A4D1A6, O75139, Q7L0X0

Related

ENSP00000479256.1, ENST00000539664.3

Conserved Domains (5) summary

cd00116
Location:249 → 364

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:351 → 363

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:85 → 108

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:589 → 667

fn3; Fibronectin type III domain

pfam13855
Location:84 → 143

LRR_8; Leucine rich repeat