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TRIM66 tripartite motif containing 66 [ Homo sapiens (human) ]

Gene ID: 9866, updated on 11-Apr-2024

Summary

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Official Symbol
TRIM66provided by HGNC
Official Full Name
tripartite motif containing 66provided by HGNC
Primary source
HGNC:HGNC:29005
See related
Ensembl:ENSG00000166436 MIM:612000; AllianceGenome:HGNC:29005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIF1D; C11orf29; TIF1DELTA
Summary
Predicted to enable chromatin binding activity and identical protein binding activity. Predicted to act upstream of or within negative regulation of transcription, DNA-templated. Located in aggresome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 4.5), skin (RPKM 3.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11p15.4
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (8612040..8683231, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (8693787..8764985, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8633587..8704778, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8271693-8272438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8272439-8273182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8281879-8282380 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8283311-8283850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8288990-8289574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8289575-8290158 Neighboring gene MPRA-validated peak1191 silencer Neighboring gene LIM domain only 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8303849-8304410 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:8304411-8304972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8339910-8340410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8347375-8347960 Neighboring gene Sharpr-MPRA regulatory region 11418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8358075-8358892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8359711-8360526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8360626-8361287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:8373273-8373772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4384 Neighboring gene serine/threonine kinase 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4385 Neighboring gene small Cajal body-specific RNA 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3114 Neighboring gene NANOG hESC enhancer GRCh37_chr11:8625413-8625914 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:8692389-8692996 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:8703769-8704968 Neighboring gene small nucleolar RNA, H/ACA box 3A Neighboring gene small nucleolar RNA, H/ACA box 3B Neighboring gene ribosomal protein L27a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TRIM66 Promotes Malignant Progression of Non-Small-Cell Lung Cancer Cells via Targeting MMP9. Xu Y, et al. Comput Math Methods Med, 2022. PMID 35912155, Free PMC Article
  2. Knockdown of TRIM66 in MDA-MB-468 triple negative breast cancer cell line suppresses proliferation and promotes apoptosis through EGFR signaling. Zhang H, et al. Pol J Pathol, 2021. PMID 34706523
  3. Association of the SNP rs112369934 near TRIM66 Gene with POAG Endophenotypes in African Americans. Kim CD, et al. Genes (Basel), 2021 Sep 15. PMID 34573402, Free PMC Article
  4. TRIM66 promotes malignant progression of prostate carcinoma through the JAK/STAT pathway. Cao H, et al. FEBS Open Bio, 2020 Apr. PMID 31981447, Free PMC Article
  5. TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells. Chen J, et al. Nat Commun, 2019 Sep 19. PMID 31537782, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ-SATB2 (hsa_circ_0008928) and miR-150-5p are regulators of TRIM66 in the regulation of NSCLC cell growth and metastasis of NSCLC cells via the ceRNA pathway.
    Title: Circ-SATB2 (hsa_circ_0008928) and miR-150-5p are regulators of TRIM66 in the regulation of NSCLC cell growth and metastasis of NSCLC cells via the ceRNA pathway.
  2. TRIM66 Promotes Malignant Progression of Non-Small-Cell Lung Cancer Cells via Targeting MMP9.
    Title: TRIM66 Promotes Malignant Progression of Non-Small-Cell Lung Cancer Cells via Targeting MMP9.
  3. TRIM66 hastens the malignant progression of non-small cell lung cancer via modulating MMP9-mediated TGF-beta/SMAD pathway.
    Title: TRIM66 hastens the malignant progression of non-small cell lung cancer via modulating MMP9-mediated TGF-β/SMAD pathway.
  4. Association of the SNP rs112369934 near TRIM66 Gene with POAG Endophenotypes in African Americans.
    Title: Association of the SNP rs112369934 near TRIM66 Gene with POAG Endophenotypes in African Americans.
  5. Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis.
    Title: Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis.
  6. Knockdown of TRIM66 in MDA-MB-468 triple negative breast cancer cell line suppresses proliferation and promotes apoptosis through EGFR signaling.
    Title: Knockdown of TRIM66 in MDA-MB-468 triple negative breast cancer cell line suppresses proliferation and promotes apoptosis through EGFR signaling.
  7. TRIM66 promotes malignant progression of prostate carcinoma through the JAK/STAT pathway.
    Title: TRIM66 promotes malignant progression of prostate carcinoma through the JAK/STAT pathway.
  8. TRIM66 recruits Sirt6 to deacetylate H3K56ac, negatively regulating the level of H3K56ac and facilitating the initiation of DNA damage repair. Importantly, Trim66-deficient blastocysts also exhibit higher levels of H3K56ac and DNA damage.
    Title: TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells.
  9. High TRIM66 expression is associated with cell proliferation, migration and invasion in colorectal cancer through JAK2/STAT3 pathway.
    Title: Knockdown of TRIM66 inhibits cell proliferation, migration and invasion in colorectal cancer through JAK2/STAT3 pathway.
  10. TRIM66 functioned as an oncogenic protein in HCC by promoting the activation of Wnt/beta-catenin signaling
    Title: TRIM66 confers tumorigenicity of hepatocellular carcinoma cells by regulating GSK-3β-dependent Wnt/β-catenin signaling.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of tripartite motif containing 66 (TRIM66) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10046

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tripartite motif-containing protein 66
Names
transcriptional intermediary factor 1 delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388022.1 → NP_001374951.1  tripartite motif-containing protein 66 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091053, AC104360
    Consensus CDS
    CCDS91432.1
    UniProtKB/Swiss-Prot
    A0A2R8YEA1, O15016, Q9BQQ4
    UniProtKB/TrEMBL
    A0A8Z5E822
    Related
    ENSP00000495413.1, ENST00000646038.2
    Conserved Domains (5) summary
    cd05502
    Location:1218 → 1326
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:253 → 378
    BBC; B-Box C-terminal domain
    cd19794
    Location:208 → 250
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:149 → 185
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:1145 → 1193
    PHD_SF; PHD finger superfamily

  2. NM_001388023.1 → NP_001374952.1  tripartite motif-containing protein 66 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091053, AC104360
    Consensus CDS
    CCDS91433.1
    UniProtKB/Swiss-Prot
    A0A2R8YEA1, O15016, Q9BQQ4
    UniProtKB/TrEMBL
    A0A994J572
    Related
    ENSP00000516162.1, ENST00000705689.1
    Conserved Domains (5) summary
    cd05502
    Location:1181 → 1289
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:216 → 341
    BBC; B-Box C-terminal domain
    cd19794
    Location:171 → 213
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:112 → 148
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:1108 → 1156
    PHD_SF; PHD finger superfamily

  3. NM_001388024.1 → NP_001374953.1  tripartite motif-containing protein 66 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091053, AC104360
    UniProtKB/Swiss-Prot
    A0A2R8YEA1, O15016, Q9BQQ4
    Conserved Domains (6) summary
    cd05502
    Location:1190 → 1298
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:253 → 378
    BBC; B-Box C-terminal domain
    TIGR00601
    Location:710 → 909
    rad23; UV excision repair protein Rad23
    cd19794
    Location:208 → 250
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:149 → 185
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:1117 → 1165
    PHD_SF; PHD finger superfamily

  4. NM_014818.2 → NP_055633.1  tripartite motif-containing protein 66 isoform 1

    See identical proteins and their annotated locations for NP_055633.1

    Status: VALIDATED

    Source sequence(s)
    AC091053, AC104360
    UniProtKB/TrEMBL
    A0A994J5L5
    Conserved Domains (4) summary
    cd05502
    Location:1042 → 1150
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    cd00021
    Location:64 → 99
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:969 → 1017
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    8612040..8683231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018629.2 → XP_016874118.1  tripartite motif-containing protein 66 isoform X1

    UniProtKB/Swiss-Prot
    A0A2R8YEA1, O15016, Q9BQQ4
    UniProtKB/TrEMBL
    A0A8Z5E822
    Conserved Domains (5) summary
    cd05502
    Location:1218 → 1326
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:253 → 378
    BBC; B-Box C-terminal domain
    cd19794
    Location:208 → 250
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:149 → 185
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:1145 → 1193
    PHD_SF; PHD finger superfamily

  2. XM_047427941.1 → XP_047283897.1  tripartite motif-containing protein 66 isoform X4

  3. XM_011520507.4 → XP_011518809.1  tripartite motif-containing protein 66 isoform X1

    See identical proteins and their annotated locations for XP_011518809.1

    UniProtKB/Swiss-Prot
    A0A2R8YEA1, O15016, Q9BQQ4
    UniProtKB/TrEMBL
    A0A8Z5E822
    Conserved Domains (5) summary
    cd05502
    Location:1218 → 1326
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:253 → 378
    BBC; B-Box C-terminal domain
    cd19794
    Location:208 → 250
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:149 → 185
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:1145 → 1193
    PHD_SF; PHD finger superfamily

  4. XM_047427943.1 → XP_047283899.1  tripartite motif-containing protein 66 isoform X6

  5. XM_011520510.2 → XP_011518812.1  tripartite motif-containing protein 66 isoform X4

    UniProtKB/Swiss-Prot
    A0A2R8YEA1, O15016, Q9BQQ4
    Conserved Domains (6) summary
    cd05502
    Location:1190 → 1298
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:253 → 378
    BBC; B-Box C-terminal domain
    TIGR00601
    Location:710 → 909
    rad23; UV excision repair protein Rad23
    cd19794
    Location:208 → 250
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:149 → 185
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:1117 → 1165
    PHD_SF; PHD finger superfamily

  6. XM_011520509.2 → XP_011518811.1  tripartite motif-containing protein 66 isoform X3

    UniProtKB/Swiss-Prot
    A0A2R8YEA1, O15016, Q9BQQ4
    Conserved Domains (4) summary
    smart00502
    Location:253 → 378
    BBC; B-Box C-terminal domain
    cd00021
    Location:209 → 244
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl02556
    Location:1225 → 1301
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    cl22851
    Location:1145 → 1193
    PHD_SF; PHD finger superfamily

  7. XM_011520508.3 → XP_011518810.1  tripartite motif-containing protein 66 isoform X2

    UniProtKB/Swiss-Prot
    A0A2R8YEA1, O15016, Q9BQQ4
    Conserved Domains (6) summary
    cd05502
    Location:1218 → 1326
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:253 → 378
    BBC; B-Box C-terminal domain
    pfam05109
    Location:722 → 894
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd19794
    Location:208 → 250
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:149 → 185
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:1145 → 1193
    PHD_SF; PHD finger superfamily

  8. XM_047427944.1 → XP_047283900.1  tripartite motif-containing protein 66 isoform X6

  9. XM_047427942.1 → XP_047283898.1  tripartite motif-containing protein 66 isoform X5

    UniProtKB/TrEMBL
    A0A994J572

  10. XM_047427940.1 → XP_047283896.1  tripartite motif-containing protein 66 isoform X4

  11. XM_011520504.1 → XP_011518806.1  tripartite motif-containing protein 66 isoform X1

    See identical proteins and their annotated locations for XP_011518806.1

    UniProtKB/Swiss-Prot
    A0A2R8YEA1, O15016, Q9BQQ4
    UniProtKB/TrEMBL
    A0A8Z5E822
    Conserved Domains (5) summary
    cd05502
    Location:1218 → 1326
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:253 → 378
    BBC; B-Box C-terminal domain
    cd19794
    Location:208 → 250
    Bbox2_TRIM66-like; B-box-type 2 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cd19811
    Location:149 → 185
    Bbox1_TRIM66; B-box-type 1 zinc finger found in tripartite motif-containing protein 66 (TRIM66) and similar proteins
    cl22851
    Location:1145 → 1193
    PHD_SF; PHD finger superfamily

  12. XM_011520516.1 → XP_011518818.1  tripartite motif-containing protein 66 isoform X9

    See identical proteins and their annotated locations for XP_011518818.1

    UniProtKB/TrEMBL
    A0A994J5L5, A0A994J7V7
    Conserved Domains (4) summary
    cd05502
    Location:1073 → 1181
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    cd00021
    Location:64 → 99
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:1000 → 1048
    PHD_SF; PHD finger superfamily

  13. XM_011520519.1 → XP_011518821.1  tripartite motif-containing protein 66 isoform X9

    See identical proteins and their annotated locations for XP_011518821.1

    UniProtKB/TrEMBL
    A0A994J5L5, A0A994J7V7
    Conserved Domains (4) summary
    cd05502
    Location:1073 → 1181
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    cd00021
    Location:64 → 99
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:1000 → 1048
    PHD_SF; PHD finger superfamily

  14. XM_011520513.1 → XP_011518815.1  tripartite motif-containing protein 66 isoform X7

    See identical proteins and their annotated locations for XP_011518815.1

    UniProtKB/TrEMBL
    A0A994J5L5
    Conserved Domains (4) summary
    cd05502
    Location:1132 → 1240
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:167 → 292
    BBC; B-Box C-terminal domain
    cd00021
    Location:123 → 158
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:1059 → 1107
    PHD_SF; PHD finger superfamily

  15. XM_011520512.1 → XP_011518814.1  tripartite motif-containing protein 66 isoform X7

    See identical proteins and their annotated locations for XP_011518814.1

    UniProtKB/TrEMBL
    A0A994J5L5
    Conserved Domains (4) summary
    cd05502
    Location:1132 → 1240
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:167 → 292
    BBC; B-Box C-terminal domain
    cd00021
    Location:123 → 158
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:1059 → 1107
    PHD_SF; PHD finger superfamily

  16. XM_047427945.1 → XP_047283901.1  tripartite motif-containing protein 66 isoform X8

  17. XM_011520514.3 → XP_011518816.1  tripartite motif-containing protein 66 isoform X7

    See identical proteins and their annotated locations for XP_011518816.1

    UniProtKB/TrEMBL
    A0A994J5L5
    Conserved Domains (4) summary
    cd05502
    Location:1132 → 1240
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:167 → 292
    BBC; B-Box C-terminal domain
    cd00021
    Location:123 → 158
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:1059 → 1107
    PHD_SF; PHD finger superfamily

  18. XM_047427946.1 → XP_047283902.1  tripartite motif-containing protein 66 isoform X9

    UniProtKB/TrEMBL
    A0A994J7V7

  19. XM_011520515.1 → XP_011518817.1  tripartite motif-containing protein 66 isoform X9

    See identical proteins and their annotated locations for XP_011518817.1

    UniProtKB/TrEMBL
    A0A994J5L5, A0A994J7V7
    Conserved Domains (4) summary
    cd05502
    Location:1073 → 1181
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    cd00021
    Location:64 → 99
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:1000 → 1048
    PHD_SF; PHD finger superfamily

  20. XM_011520522.3 → XP_011518824.1  tripartite motif-containing protein 66 isoform X9

    See identical proteins and their annotated locations for XP_011518824.1

    UniProtKB/TrEMBL
    A0A994J5L5, A0A994J7V7
    Related
    ENSP00000516163.1, ENST00000705690.1
    Conserved Domains (4) summary
    cd05502
    Location:1073 → 1181
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    cd00021
    Location:64 → 99
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:1000 → 1048
    PHD_SF; PHD finger superfamily

  21. XM_006718398.4 → XP_006718461.1  tripartite motif-containing protein 66 isoform X9

    See identical proteins and their annotated locations for XP_006718461.1

    UniProtKB/TrEMBL
    A0A994J5L5, A0A994J7V7
    Conserved Domains (4) summary
    cd05502
    Location:1073 → 1181
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    cd00021
    Location:64 → 99
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:1000 → 1048
    PHD_SF; PHD finger superfamily

  22. XM_011520517.3 → XP_011518819.1  tripartite motif-containing protein 66 isoform X9

    See identical proteins and their annotated locations for XP_011518819.1

    UniProtKB/TrEMBL
    A0A994J5L5, A0A994J7V7
    Conserved Domains (4) summary
    cd05502
    Location:1073 → 1181
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    cd00021
    Location:64 → 99
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:1000 → 1048
    PHD_SF; PHD finger superfamily

  23. XM_017018631.1 → XP_016874120.1  tripartite motif-containing protein 66 isoform X9

    UniProtKB/TrEMBL
    A0A994J5L5, A0A994J7V7
    Conserved Domains (4) summary
    cd05502
    Location:1073 → 1181
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    smart00502
    Location:108 → 233
    BBC; B-Box C-terminal domain
    cd00021
    Location:64 → 99
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cl22851
    Location:1000 → 1048
    PHD_SF; PHD finger superfamily

  24. XM_047427947.1 → XP_047283903.1  tripartite motif-containing protein 66 isoform X10

  25. XM_011520527.2 → XP_011518829.1  tripartite motif-containing protein 66 isoform X15

    Conserved Domains (2) summary
    cd05502
    Location:569 → 677
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    cd15625
    Location:496 → 544
    PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)

  26. XM_047427948.1 → XP_047283904.1  tripartite motif-containing protein 66 isoform X14

  27. XM_011520526.3 → XP_011518828.1  tripartite motif-containing protein 66 isoform X13

    Conserved Domains (2) summary
    cd05502
    Location:827 → 935
    Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
    cd15625
    Location:754 → 802
    PHD_TIF1delta; PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta)

  28. XM_011520524.2 → XP_011518826.1  tripartite motif-containing protein 66 isoform X11

    Conserved Domains (2) summary
    smart00502
    Location:253 → 378
    BBC; B-Box C-terminal domain
    cd00021
    Location:209 → 244
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

  29. XM_011520525.2 → XP_011518827.1  tripartite motif-containing protein 66 isoform X12

    Conserved Domains (2) summary
    smart00502
    Location:253 → 378
    BBC; B-Box C-terminal domain
    cd00021
    Location:209 → 244
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

RNA

  1. XR_930930.2 RNA Sequence

  2. XR_930929.2 RNA Sequence

  3. XR_930931.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    8693787..8764985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370650.1 → XP_054226625.1  tripartite motif-containing protein 66 isoform X1

  2. XM_054370655.1 → XP_054226630.1  tripartite motif-containing protein 66 isoform X4

  3. XM_054370649.1 → XP_054226624.1  tripartite motif-containing protein 66 isoform X1

  4. XM_054370657.1 → XP_054226632.1  tripartite motif-containing protein 66 isoform X6

  5. XM_054370653.1 → XP_054226628.1  tripartite motif-containing protein 66 isoform X4

  6. XM_054370652.1 → XP_054226627.1  tripartite motif-containing protein 66 isoform X3

  7. XM_054370651.1 → XP_054226626.1  tripartite motif-containing protein 66 isoform X2

  8. XM_054370658.1 → XP_054226633.1  tripartite motif-containing protein 66 isoform X6

  9. XM_054370656.1 → XP_054226631.1  tripartite motif-containing protein 66 isoform X5

  10. XM_054370654.1 → XP_054226629.1  tripartite motif-containing protein 66 isoform X4

  11. XM_054370648.1 → XP_054226623.1  tripartite motif-containing protein 66 isoform X1

  12. XM_054370664.1 → XP_054226639.1  tripartite motif-containing protein 66 isoform X9

  13. XM_054370667.1 → XP_054226642.1  tripartite motif-containing protein 66 isoform X9

  14. XM_054370661.1 → XP_054226636.1  tripartite motif-containing protein 66 isoform X7

  15. XM_054370660.1 → XP_054226635.1  tripartite motif-containing protein 66 isoform X7

  16. XM_054370662.1 → XP_054226637.1  tripartite motif-containing protein 66 isoform X8

  17. XM_054370659.1 → XP_054226634.1  tripartite motif-containing protein 66 isoform X7

  18. XM_054370668.1 → XP_054226643.1  tripartite motif-containing protein 66 isoform X9

  19. XM_054370663.1 → XP_054226638.1  tripartite motif-containing protein 66 isoform X9

  20. XM_054370670.1 → XP_054226645.1  tripartite motif-containing protein 66 isoform X9

  21. XM_054370666.1 → XP_054226641.1  tripartite motif-containing protein 66 isoform X9

  22. XM_054370665.1 → XP_054226640.1  tripartite motif-containing protein 66 isoform X9

  23. XM_054370669.1 → XP_054226644.1  tripartite motif-containing protein 66 isoform X9

  24. XM_054370671.1 → XP_054226646.1  tripartite motif-containing protein 66 isoform X10

  25. XM_054370676.1 → XP_054226651.1  tripartite motif-containing protein 66 isoform X15

  26. XM_054370675.1 → XP_054226650.1  tripartite motif-containing protein 66 isoform X14

  27. XM_054370674.1 → XP_054226649.1  tripartite motif-containing protein 66 isoform X13

  28. XM_054370672.1 → XP_054226647.1  tripartite motif-containing protein 66 isoform X11

  29. XM_054370673.1 → XP_054226648.1  tripartite motif-containing protein 66 isoform X12

RNA

  1. XR_008488499.1 RNA Sequence

  2. XR_008488498.1 RNA Sequence

  3. XR_008488500.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15016.5 GenPept UniProtKB/Swiss-Prot:O15016

Gene LinkOut

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