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Ubac1 ubiquitin associated domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 98766, updated on 2-Nov-2024

Summary

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Official Symbol
Ubac1provided by MGI
Official Full Name
ubiquitin associated domain containing 1provided by MGI
Primary source
MGI:MGI:1920995
See related
Ensembl:ENSMUSG00000036352 AllianceGenome:MGI:1920995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kpc2; GBDR1; Gdbr1; Ubadc1; 1110033G07Rik
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity and proteasome binding activity. Predicted to be involved in protein maturation and protein ubiquitination. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of ubiquitin ligase complex. Is expressed in several structures, including cranial ganglion; dorsal root ganglion; liver lobe; neural tube; and vibrissa. Orthologous to human UBAC1 (UBA domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14.5 (RPKM 72.0), liver E14 (RPKM 70.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ubac1 in Genome Data Viewer
Location:
2 A3; 2 18.29 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25886970..25911793, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25996958..26021781, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03968 Neighboring gene potassium channel, subfamily T, member 1 Neighboring gene calmodulin regulated spectrin-associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1002 Neighboring gene STARR-positive B cell enhancer ABC_E3363 Neighboring gene STARR-seq mESC enhancer starr_03972 Neighboring gene STARR-seq mESC enhancer starr_03973 Neighboring gene nucleus accumbens associated 2, BEN and BTB (POZ) domain containing Neighboring gene predicted gene, 54107

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity. Bridoux L, et al. Biochim Biophys Acta, 2015 Oct. PMID 26303204
  2. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Kamura T, et al. Nat Cell Biol, 2004 Dec. PMID 15531880
  3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our data support that KPC2 regulates Hoxa2 by promoting its relocation to the cytoplasm.
    Title: KPC2 relocalizes HOXA2 to the cytoplasm and decreases its transcriptional activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
  
enables proteasome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-associated domain-containing protein 1
Names
E3 ubiquitin-protein ligase subunit KPC2
UBA domain-containing protein 1
kip1 ubiquitination-promoting complex protein 2
putative glialblastoma cell differentiation-related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362681.1 → NP_001349610.1  ubiquitin-associated domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL731682, AL845455
    Conserved Domains (2) summary
    cd14303
    Location:195 → 232
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cl21463
    Location:294 → 325
    UBA_like_SF; UBA domain-like superfamily

  2. NM_133835.2 → NP_598596.2  ubiquitin-associated domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_598596.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK157857, AK162577, CX243095
    Consensus CDS
    CCDS15795.1
    UniProtKB/Swiss-Prot
    Q3TZH3, Q8VDI7
    Related
    ENSMUSP00000040220.8, ENSMUST00000036509.14
    Conserved Domains (3) summary
    smart00727
    Location:357 → 396
    STI1; Heat shock chaperonin-binding motif
    cd14303
    Location:195 → 232
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd14304
    Location:294 → 331
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25886970..25911793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498465.1 → XP_006498528.1  ubiquitin-associated domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd14303
    Location:195 → 232
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd17066
    Location:9 → 95
    Ubl_KPC2; ubiquitin-like (Ubl) domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

  2. XM_036162737.1 → XP_036018630.1  ubiquitin-associated domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    F6UMH9
    Conserved Domains (2) summary
    cd14303
    Location:93 → 130
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cl21463
    Location:192 → 223
    UBA_like_SF; UBA domain-like superfamily

  3. XM_030252261.2 → XP_030108121.1  ubiquitin-associated domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    smart00727
    Location:213 → 252
    STI1; Heat shock chaperonin-binding motif
    cd14303
    Location:51 → 88
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd14304
    Location:150 → 187
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

  4. XM_036162736.1 → XP_036018629.1  ubiquitin-associated domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    smart00727
    Location:255 → 294
    STI1; Heat shock chaperonin-binding motif
    cd14303
    Location:93 → 130
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd14304
    Location:192 → 229
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

  5. XM_030252260.2 → XP_030108120.1  ubiquitin-associated domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    smart00727
    Location:255 → 294
    STI1; Heat shock chaperonin-binding motif
    cd14303
    Location:93 → 130
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd14304
    Location:192 → 229
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

  6. XM_030252262.2 → XP_030108122.1  ubiquitin-associated domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    smart00727
    Location:213 → 252
    STI1; Heat shock chaperonin-binding motif
    cd14303
    Location:51 → 88
    UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cd14304
    Location:150 → 187
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

RNA

  1. XR_004940785.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDI7.2 GenPept UniProtKB/Swiss-Prot:Q8VDI7

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