Usp6nl USP6 N-terminal like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp6nlprovided by MGI
Official Full Name: USP6 N-terminal likeprovided by MGI
Primary source: MGI:MGI:2138893
See related: Ensembl:ENSMUSG00000039046 AllianceGenome:MGI:2138893
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RNTRE; TRE2NL; mKIAA0019
Summary: Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including plasma membrane to endosome transport; positive regulation of GTPase activity; and retrograde transport, plasma membrane to Golgi. Predicted to be located in plasma membrane. Predicted to be active in cytoplasmic vesicle. Orthologous to human USP6NL (USP6 N-terminal like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 3.1), CNS E11.5 (RPKM 2.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 3.63 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (6327444..6453107)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (6322757..6448296)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings identify RN-tre as the Rab5-GAP that spatiotemporally controls focal adhesion remodeling during chemotactic cell migration.
Title: The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane to endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane to endosome transport	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane to endosome transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, plasma membrane to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, plasma membrane to Golgi	ISS Inferred from Sequence or Structural Similarity more info
involved_in virion assembly	IEA Inferred from Electronic Annotation more info
involved_in virion assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: USP6 N-terminal-like protein

Names: novel TBC domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080548.1 → NP_001074017.1 USP6 N-terminal-like protein isoform b

See identical proteins and their annotated locations for NP_001074017.1

Status: VALIDATED

Source sequence(s)

AK129037, AL845515, BE949333

Consensus CDS

CCDS38043.1

UniProtKB/Swiss-Prot

A2AR45, A2AR46, Q3U2W3, Q6ZQK8, Q80XC3

Related

ENSMUSP00000110587.2, ENSMUST00000114937.8

Conserved Domains (2) summary

PTZ00449
Location:503 → 715

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00164
Location:97 → 312

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
NM_181399.3 → NP_852064.2 USP6 N-terminal-like protein isoform a

Status: VALIDATED

Source sequence(s)

AL845515, BQ938063, CN455065

Consensus CDS

CCDS38044.1

UniProtKB/Swiss-Prot

Q80XC3

Related

ENSMUSP00000043178.9, ENSMUST00000042503.9

Conserved Domains (2) summary

smart00164
Location:120 → 335

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

pfam14820
Location:590 → 642

SPRR2; Small proline-rich 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

6327444..6453107

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252265.2 → XP_030108125.1 USP6 N-terminal-like protein isoform X7

Conserved Domains (2) summary

PTZ00449
Location:424 → 636

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00164
Location:18 → 233

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_030252264.1 → XP_030108124.1 USP6 N-terminal-like protein isoform X6

Conserved Domains (2) summary

PTZ00449
Location:432 → 644

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00164
Location:26 → 241

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_036162740.1 → XP_036018633.1 USP6 N-terminal-like protein isoform X7

Conserved Domains (2) summary

PTZ00449
Location:424 → 636

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00164
Location:18 → 233

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_006497570.4 → XP_006497633.1 USP6 N-terminal-like protein isoform X5

Conserved Domains (2) summary

PTZ00449
Location:454 → 666

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00164
Location:48 → 263

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_036162739.1 → XP_036018632.1 USP6 N-terminal-like protein isoform X4

Conserved Domains (2) summary

PTZ00449
Location:462 → 674

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00164
Location:56 → 271

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_006497569.5 → XP_006497632.1 USP6 N-terminal-like protein isoform X2

See identical proteins and their annotated locations for XP_006497632.1

UniProtKB/Swiss-Prot

A2AR45, A2AR46, Q3U2W3, Q6ZQK8, Q80XC3

Conserved Domains (2) summary

PTZ00449
Location:503 → 715

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00164
Location:97 → 312

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_036162738.1 → XP_036018631.1 USP6 N-terminal-like protein isoform X3

Conserved Domains (2) summary

PTZ00449
Location:479 → 691

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00164
Location:73 → 288

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_006497568.5 → XP_006497631.1 USP6 N-terminal-like protein isoform X1

Conserved Domains (2) summary

PTZ00449
Location:520 → 732

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00164
Location:114 → 329

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
XM_011238993.2 → XP_011237295.1 USP6 N-terminal-like protein isoform X6

See identical proteins and their annotated locations for XP_011237295.1

Conserved Domains (2) summary

PTZ00449
Location:432 → 644

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00164
Location:26 → 241

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs