U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KLHL21 kelch like family member 21 [ Homo sapiens (human) ]

Gene ID: 9903, updated on 2-Nov-2024

Summary

Official Symbol
KLHL21provided by HGNC
Official Full Name
kelch like family member 21provided by HGNC
Primary source
HGNC:HGNC:29041
See related
Ensembl:ENSG00000162413 MIM:616262; AllianceGenome:HGNC:29041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables cullin family protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis. Located in polar microtubule. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in fat (RPKM 17.4), ovary (RPKM 14.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KLHL21 in Genome Data Viewer
Location:
1p36.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6590724..6602869, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (6116388..6128533, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6650784..6662929, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene taste 1 receptor member 1 Neighboring gene uncharacterized LOC107984912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6639438-6640137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 83 Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:6658990-6660189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 84 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 85 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 86 Neighboring gene uncharacterized LOC107984913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 87 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 88 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6664299-6664647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 170 Neighboring gene PHD finger protein 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0469, MGC99635

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cullin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome passenger complex localization to spindle midzone IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in polar microtubule IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324309.2NP_001311238.1  kelch-like protein 21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591866
    Related
    ENSP00000366891.3, ENST00000377663.3
    Conserved Domains (5) summary
    PHA03098
    Location:49493
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:326368
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:25130
    BTB; BTB/POZ domain
    pfam01344
    Location:327368
    Kelch_1; Kelch motif
    pfam07707
    Location:138239
    BACK; BTB And C-terminal Kelch
  2. NM_014851.4NP_055666.2  kelch-like protein 21 isoform 1

    See identical proteins and their annotated locations for NP_055666.2

    Status: VALIDATED

    Source sequence(s)
    AB007938, BC064980
    Consensus CDS
    CCDS30575.1
    UniProtKB/Swiss-Prot
    B3KQP2, O75057, Q5SY26, Q5SY28, Q8N4I6, Q8NF10, Q9UJP4
    Related
    ENSP00000366886.4, ENST00000377658.8
    Conserved Domains (7) summary
    smart00612
    Location:482512
    Kelch; Kelch domain
    PHA03098
    Location:49547
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:326368
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:25130
    BTB; BTB/POZ domain
    pfam01344
    Location:327368
    Kelch_1; Kelch motif
    pfam07707
    Location:138239
    BACK; BTB And C-terminal Kelch
    pfam13964
    Location:502549
    Kelch_6; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    6590724..6602869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    6116388..6128533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)