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IQSEC1 IQ motif and Sec7 domain ArfGEF 1 [ Homo sapiens (human) ]

Gene ID: 9922, updated on 2-Nov-2024

Summary

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Official Symbol
IQSEC1provided by HGNC
Official Full Name
IQ motif and Sec7 domain ArfGEF 1provided by HGNC
Primary source
HGNC:HGNC:29112
See related
Ensembl:ENSG00000144711 MIM:610166; AllianceGenome:HGNC:29112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRAG2; GEP100; IDDSSBA; ARFGEP100; ARF-GEP100
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of postsynaptic neurotransmitter receptor internalization. Located in nucleolus. Implicated in intellectual developmental disorder with short stature and behavioral abnormalities and lung adenocarcinoma. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 17.9), bone marrow (RPKM 13.3) and 25 other tissues See more
Orthologs
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Genomic context

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See IQSEC1 in Genome Data Viewer
Location:
3p25.2-p25.1
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (12897043..13283257, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (12898545..13283599, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12938542..13324757, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124909346 Neighboring gene microtubule affinity regulating kinase 4 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14071 Neighboring gene uncharacterized LOC105376956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12918177-12918689 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12917663-12918176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19458 Neighboring gene long intergenic non-protein coding RNA 2022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12969075-12969574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12977492-12978056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12985145-12985725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12985857-12986542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12986543-12987228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12988583-12989084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12999703-13000203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19462 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:13020550-13021749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14076 Neighboring gene Sharpr-MPRA regulatory region 2966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13035123-13035681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19463 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13036241-13036799 Neighboring gene Sharpr-MPRA regulatory region 4746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19466 Neighboring gene uncharacterized LOC124906214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13055383-13055884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13055885-13056384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13056642-13057410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13057411-13058178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19470 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13058755-13059554 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13059555-13060352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13060353-13061150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13068313-13068814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13068815-13069314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13072358-13073358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13073359-13074357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13076449-13076949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13083243-13083838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13088478-13088996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13098528-13099036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13099037-13099544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13121681-13122182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13122183-13122682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14083 Neighboring gene ribosomal protein L39 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13129843-13130342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13144801-13145570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13202841-13203366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13212946-13213470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13213471-13213994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13215820-13216320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13234555-13235161 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13235162-13235768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13239281-13239901 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13240462-13241008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13250445-13250980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13250981-13251518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13261232-13261755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13261756-13262278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13262279-13262801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13273335-13273836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13279021-13279625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13279626-13280229 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13283606-13283809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13295276-13296085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13296086-13296894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13298218-13298718 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13298719-13299219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13301694-13302474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13318107-13318607 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13318634-13318918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13319003-13319504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19485 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13363927-13364126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13368365-13368866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13368867-13369366 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:13372259-13372426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13387355-13388236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13389121-13390003 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13388237-13389120 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13390887-13391769 Neighboring gene nucleoporin 210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13415591-13416092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13430034-13430534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13432338-13432896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13440837-13441368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13441369-13441898 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:13442941-13443441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14085 Neighboring gene NUP210-HDAC11 intergenic CAGE-defined high expression enhancer Neighboring gene PRR3 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GEP100 regulates epidermal growth factor-induced MDA-MB-231 breast cancer cell invasion through the activation of Arf6/ERK/uPAR signaling pathway. Hu Z, et al. Exp Cell Res, 2013 Aug 1. PMID 23747719
  2. The pleckstrin homology (PH) domain of the Arf exchange factor Brag2 is an allosteric binding site. Jian X, et al. J Biol Chem, 2012 Jul 13. PMID 22613714, Free PMC Article
  3. An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nacke M, et al. Nat Commun, 2021 Mar 12. PMID 33712589, Free PMC Article
  4. BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5). Moravec R, et al. J Biol Chem, 2012 Sep 7. PMID 22815487, Free PMC Article
  5. Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex. D'Souza RS, et al. Elife, 2020 Apr 1. PMID 32234213, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Contribution of gene polymorphisms on 3p25 to salivary gland carcinoma, ameloblastoma, and odontogenic keratocyst in the Chinese Han population.
    Title: Contribution of gene polymorphisms on 3p25 to salivary gland carcinoma, ameloblastoma, and odontogenic keratocyst in the Chinese Han population.
  2. circ-Iqsec1 induces bone marrow-derived mesenchymal stem cell (BMSC) osteogenic differentiation through the miR-187-3p/Satb2 signaling pathway.
    Title: circ-Iqsec1 induces bone marrow-derived mesenchymal stem cell (BMSC) osteogenic differentiation through the miR-187-3p/Satb2 signaling pathway.
  3. An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism.
    Title: An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism.
  4. Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
    Title: Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
  5. IQSEC1 variants are the cause of a recessive disease with intellectual disability.
    Title: Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature.
  6. both Arf6 activation through GluN2B-BRAG1 during early development and the transition from BRAG1- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
    Title: Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.
  7. Brag2 is essential for developmental and pathological angiogenesis by promoting endothelial cell sprouting through regulation of adhesion by beta1-integrin internalization and link for the first time the process of beta1-integrin endocytosis with angiogenesis.
    Title: Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis.
  8. The EGFR-GEP100-Arf6 axis affected the prognosis of patients with primary lung adenocarcinoma.
    Title: Epidermal growth factor receptor-GEP100-Arf6 axis affects the prognosis of lung adenocarcinoma.
  9. Data show that co-overexpression of GEP100 and AMAP1 (ASAP1) correlates with rapidity of the local recurrence.
    Title: Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy.
  10. GEP100 regulates an Arf6/ERK/uPAR signaling cascade in EGF-induced breast cancer cell invasion.
    Title: GEP100 regulates epidermal growth factor-induced MDA-MB-231 breast cancer cell invasion through the activation of Arf6/ERK/uPAR signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual developmental disorder with short stature and behavioral abnormalities
MedGen: C5231462 OMIM: 618687 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of focal adhesion disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of keratinocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IQ motif and SEC7 domain-containing protein 1
Names
ADP-ribosylation factors guanine nucleotide-exchange protein 100
ADP-ribosylation factors guanine nucleotide-exchange protein 2
IQ motif and Sec7 domain 1
brefeldin A-resistant ARF-GEF2
brefeldin-resistant Arf-GEF 2 protein
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134382.3 → NP_001127854.1  IQ motif and SEC7 domain-containing protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC018836, AC069271, AK294525, AY653734
    Consensus CDS
    CCDS74902.1
    UniProtKB/TrEMBL
    B4DGC5
    Related
    ENSP00000480301.1, ENST00000613206.2
    Conserved Domains (2) summary
    cd13318
    Location:735 → 865
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:510 → 698
    Sec7; Sec7 domain

  2. NM_001330619.3 → NP_001317548.1  IQ motif and SEC7 domain-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC018836, AC069271, KF495709
    Consensus CDS
    CCDS87048.1
    UniProtKB/TrEMBL
    A0A0C4DGT3, A0A3B3IU98
    Related
    ENSP00000478001.1, ENST00000618604.4
    Conserved Domains (2) summary
    cd13318
    Location:627 → 757
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:402 → 590
    Sec7; Sec7 domain

  3. NM_001376938.2 → NP_001363867.1  IQ motif and SEC7 domain-containing protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC018836, AC069246, AC069271, KF495709
    Consensus CDS
    CCDS93218.1
    UniProtKB/TrEMBL
    A0A3B3IRZ4, B4DGC5
    Related
    ENSP00000497029.1, ENST00000648114.1
    Conserved Domains (2) summary
    pfam01369
    Location:618 → 806
    Sec7; Sec7 domain
    pfam16453
    Location:838 → 968
    IQ_SEC7_PH; PH domain

  4. NM_014869.8 → NP_055684.3  IQ motif and SEC7 domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_055684.3

    Status: VALIDATED

    Source sequence(s)
    AC018836, AC069271
    Consensus CDS
    CCDS33703.1
    UniProtKB/Swiss-Prot
    A0A087WWK8, O94863, Q6DN90, Q96D85
    UniProtKB/TrEMBL
    A0A2R8Y7T6
    Related
    ENSP00000273221.4, ENST00000273221.8
    Conserved Domains (2) summary
    cd13318
    Location:749 → 879
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:524 → 712
    Sec7; Sec7 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    12897043..13283257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449348.1 → XP_047305304.1  IQ motif and SEC7 domain-containing protein 1 isoform X12

  2. XM_047449340.1 → XP_047305296.1  IQ motif and SEC7 domain-containing protein 1 isoform X2

  3. XM_047449347.1 → XP_047305303.1  IQ motif and SEC7 domain-containing protein 1 isoform X11

  4. XM_047449339.1 → XP_047305295.1  IQ motif and SEC7 domain-containing protein 1 isoform X1

  5. XM_047449346.1 → XP_047305302.1  IQ motif and SEC7 domain-containing protein 1 isoform X10

  6. XM_047449358.1 → XP_047305314.1  IQ motif and SEC7 domain-containing protein 1 isoform X20

  7. XM_047449357.1 → XP_047305313.1  IQ motif and SEC7 domain-containing protein 1 isoform X19

  8. XM_047449342.1 → XP_047305298.1  IQ motif and SEC7 domain-containing protein 1 isoform X7

  9. XM_047449354.1 → XP_047305310.1  IQ motif and SEC7 domain-containing protein 1 isoform X16

  10. XM_011534307.3 → XP_011532609.1  IQ motif and SEC7 domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    B4DGC5
    Conserved Domains (2) summary
    cd13318
    Location:750 → 880
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:525 → 713
    Sec7; Sec7 domain

  11. XM_047449352.1 → XP_047305308.1  IQ motif and SEC7 domain-containing protein 1 isoform X14

    Related
    ENSP00000495163.1, ENST00000647458.1

  12. XM_047449341.1 → XP_047305297.1  IQ motif and SEC7 domain-containing protein 1 isoform X6

  13. XM_047449353.1 → XP_047305309.1  IQ motif and SEC7 domain-containing protein 1 isoform X15

  14. XM_011534306.4 → XP_011532608.1  IQ motif and SEC7 domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    B4DGC5
    Conserved Domains (2) summary
    cd13318
    Location:750 → 880
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:525 → 713
    Sec7; Sec7 domain

  15. XM_011534313.3 → XP_011532615.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

    See identical proteins and their annotated locations for XP_011532615.1

    UniProtKB/TrEMBL
    B4DGC5
    Conserved Domains (2) summary
    cd13318
    Location:627 → 757
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:402 → 590
    Sec7; Sec7 domain

  16. XM_047449349.1 → XP_047305305.1  IQ motif and SEC7 domain-containing protein 1 isoform X13

  17. XM_047449360.1 → XP_047305316.1  IQ motif and SEC7 domain-containing protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A0C4DGT3

  18. XM_011534311.3 → XP_011532613.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

    See identical proteins and their annotated locations for XP_011532613.1

    UniProtKB/TrEMBL
    B4DGC5
    Conserved Domains (2) summary
    cd13318
    Location:627 → 757
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:402 → 590
    Sec7; Sec7 domain

  19. XM_047449361.1 → XP_047305317.1  IQ motif and SEC7 domain-containing protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A0C4DGT3

  20. XM_011534312.3 → XP_011532614.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

    See identical proteins and their annotated locations for XP_011532614.1

    UniProtKB/TrEMBL
    B4DGC5
    Conserved Domains (2) summary
    cd13318
    Location:627 → 757
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:402 → 590
    Sec7; Sec7 domain

  21. XM_047449345.1 → XP_047305301.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

  22. XM_047449359.1 → XP_047305315.1  IQ motif and SEC7 domain-containing protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A0C4DGT3

  23. XM_047449350.1 → XP_047305306.1  IQ motif and SEC7 domain-containing protein 1 isoform X13

  24. XM_011534314.3 → XP_011532616.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

    See identical proteins and their annotated locations for XP_011532616.1

    UniProtKB/TrEMBL
    B4DGC5
    Conserved Domains (2) summary
    cd13318
    Location:627 → 757
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:402 → 590
    Sec7; Sec7 domain

  25. XM_047449356.1 → XP_047305312.1  IQ motif and SEC7 domain-containing protein 1 isoform X18

  26. XM_047449343.1 → XP_047305299.1  IQ motif and SEC7 domain-containing protein 1 isoform X8

  27. XM_047449355.1 → XP_047305311.1  IQ motif and SEC7 domain-containing protein 1 isoform X17

  28. XM_011534308.3 → XP_011532610.1  IQ motif and SEC7 domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    B4DGC5
    Conserved Domains (2) summary
    cd13318
    Location:749 → 879
    PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
    pfam01369
    Location:524 → 712
    Sec7; Sec7 domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    12898545..13283599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348621.1 → XP_054204596.1  IQ motif and SEC7 domain-containing protein 1 isoform X12

  2. XM_054348611.1 → XP_054204586.1  IQ motif and SEC7 domain-containing protein 1 isoform X2

  3. XM_054348620.1 → XP_054204595.1  IQ motif and SEC7 domain-containing protein 1 isoform X11

  4. XM_054348610.1 → XP_054204585.1  IQ motif and SEC7 domain-containing protein 1 isoform X1

  5. XM_054348619.1 → XP_054204594.1  IQ motif and SEC7 domain-containing protein 1 isoform X10

  6. XM_054348634.1 → XP_054204609.1  IQ motif and SEC7 domain-containing protein 1 isoform X20

  7. XM_054348633.1 → XP_054204608.1  IQ motif and SEC7 domain-containing protein 1 isoform X19

  8. XM_054348616.1 → XP_054204591.1  IQ motif and SEC7 domain-containing protein 1 isoform X7

  9. XM_054348630.1 → XP_054204605.1  IQ motif and SEC7 domain-containing protein 1 isoform X16

  10. XM_054348613.1 → XP_054204588.1  IQ motif and SEC7 domain-containing protein 1 isoform X4

  11. XM_054348628.1 → XP_054204603.1  IQ motif and SEC7 domain-containing protein 1 isoform X14

  12. XM_054348612.1 → XP_054204587.1  IQ motif and SEC7 domain-containing protein 1 isoform X3

  13. XM_054348629.1 → XP_054204604.1  IQ motif and SEC7 domain-containing protein 1 isoform X15

  14. XM_054348615.1 → XP_054204590.1  IQ motif and SEC7 domain-containing protein 1 isoform X6

  15. XM_054348625.1 → XP_054204600.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

  16. XM_054348626.1 → XP_054204601.1  IQ motif and SEC7 domain-containing protein 1 isoform X13

  17. XM_054348622.1 → XP_054204597.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

  18. XM_054348636.1 → XP_054204611.1  IQ motif and SEC7 domain-containing protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A0C4DGT3

  19. XM_054348637.1 → XP_054204612.1  IQ motif and SEC7 domain-containing protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A0C4DGT3

  20. XM_054348624.1 → XP_054204599.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

  21. XM_054348618.1 → XP_054204593.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

  22. XM_054348635.1 → XP_054204610.1  IQ motif and SEC7 domain-containing protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A0C4DGT3

  23. XM_054348627.1 → XP_054204602.1  IQ motif and SEC7 domain-containing protein 1 isoform X13

  24. XM_054348623.1 → XP_054204598.1  IQ motif and SEC7 domain-containing protein 1 isoform X9

  25. XM_054348631.1 → XP_054204606.1  IQ motif and SEC7 domain-containing protein 1 isoform X17

  26. XM_054348614.1 → XP_054204589.1  IQ motif and SEC7 domain-containing protein 1 isoform X5

  27. XM_054348632.1 → XP_054204607.1  IQ motif and SEC7 domain-containing protein 1 isoform X18

  28. XM_054348617.1 → XP_054204592.1  IQ motif and SEC7 domain-containing protein 1 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DN90.1 GenPept UniProtKB/Swiss-Prot:Q6DN90

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