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Tm9sf4 transmembrane 9 superfamily member 4 [ Mus musculus (house mouse) ]

Gene ID: 99237, updated on 2-Nov-2024

Summary

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Official Symbol
Tm9sf4provided by MGI
Official Full Name
transmembrane 9 superfamily member 4provided by MGI
Primary source
MGI:MGI:2139220
See related
Ensembl:ENSMUSG00000068040 AllianceGenome:MGI:2139220
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0255; B930079E06
Summary
Predicted to be involved in several processes, including positive regulation of protein localization; regulation of intracellular pH; and vacuolar proton-transporting V-type ATPase complex assembly. Predicted to be located in Golgi apparatus and early endosome. Predicted to be active in membrane. Is expressed in several structures, including central nervous system; eye; liver; muscle tissue; and spleen. Orthologous to human TM9SF4 (transmembrane 9 superfamily member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 30.8), limb E14.5 (RPKM 21.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tm9sf4 in Genome Data Viewer
Location:
2 H1; 2 75.41 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152999279..153052386)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153161301..153210466)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cerebral cavernous malformation 2-like Neighboring gene hemopoietic cell kinase Neighboring gene STARR-positive B cell enhancer ABC_E1605 Neighboring gene STARR-seq mESC enhancer starr_06087 Neighboring gene STARR-seq mESC enhancer starr_06088 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene TSPY-like 3 Neighboring gene pleiomorphic adenoma gene-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TM9SF4 is a novel regulator in lineage commitment of bone marrow mesenchymal stem cells to either osteoblasts or adipocytes. Yu L, et al. Stem Cell Res Ther, 2021 Nov 13. PMID 34774100, Free PMC Article
  2. TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in Inflammatory Bowel Disease. Xie M, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35398597, Free PMC Article
  3. TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation. Sun L, et al. Cell Death Differ, 2018 Feb. PMID 29125601, Free PMC Article
  4. Comparative analysis of the expression patterns of TM9SF family members in mice. Zhao R, et al. Gene Expr Patterns, 2024 Jun. PMID 38719197
  5. Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Liakath-Ali K, et al. Nat Commun, 2014 Apr 11. PMID 24721909, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TM9SF4 is a novel regulator in lineage commitment of bone marrow mesenchymal stem cells to either osteoblasts or adipocytes.
    Title: TM9SF4 is a novel regulator in lineage commitment of bone marrow mesenchymal stem cells to either osteoblasts or adipocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • KIAA0255, MGC117930

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein exit from endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein exit from endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of intracellular pH IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar proton-transporting V-type ATPase complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane 9 superfamily member 4
Names
transmembrane 9 superfamily protein member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133847.3 → NP_598608.2  transmembrane 9 superfamily member 4 precursor

    See identical proteins and their annotated locations for NP_598608.2

    Status: PROVISIONAL

    Source sequence(s)
    AL807380
    Consensus CDS
    CCDS16906.1
    UniProtKB/Swiss-Prot
    Q2TBF8, Q3TB27, Q8BH24, Q8BU80, Q8BXB4, Q8CHH4
    UniProtKB/TrEMBL
    Q14B57
    Related
    ENSMUSP00000086422.3, ENSMUST00000089027.3
    Conserved Domains (1) summary
    pfam02990
    Location:55 → 600
    EMP70; Endomembrane protein 70

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152999279..153052386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500476.4 → XP_006500539.1  transmembrane 9 superfamily member 4 isoform X1

    UniProtKB/TrEMBL
    Q14B57
    Conserved Domains (1) summary
    pfam02990
    Location:56 → 601
    EMP70; Endomembrane protein 70

  2. XM_030252272.2 → XP_030108132.1  transmembrane 9 superfamily member 4 isoform X2

    Conserved Domains (1) summary
    pfam02990
    Location:1 → 327
    EMP70; Endomembrane protein 70

  3. XM_006500477.3 → XP_006500540.1  transmembrane 9 superfamily member 4 isoform X2

    Conserved Domains (1) summary
    pfam02990
    Location:1 → 327
    EMP70; Endomembrane protein 70
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH24.1 GenPept UniProtKB/Swiss-Prot:Q8BH24

Gene LinkOut

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