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Duox1 dual oxidase 1 [ Mus musculus (house mouse) ]

Gene ID: 99439, updated on 5-Nov-2024

Summary

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Official Symbol
Duox1provided by MGI
Official Full Name
dual oxidase 1provided by MGI
Primary source
MGI:MGI:2139422
See related
Ensembl:ENSMUSG00000033268 AllianceGenome:MGI:2139422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Duox2; LNOX1; LNOX2; THOX1; THOX2; NOXEF1; NOXEF2; P138-TOX; 9930101G15Rik
Summary
Predicted to enable superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within reactive oxygen species metabolic process. Located in plasma membrane. Is expressed in brain; placenta; and thyroid gland. Orthologous to human DUOX1 (dual oxidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in stomach adult (RPKM 3.3), bladder adult (RPKM 2.4) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Duox1 in Genome Data Viewer
Location:
2 E5; 2 60.63 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122143525..122178454)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122313010..122347972)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dual oxidase 2 Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene STARR-seq mESC enhancer starr_05553 Neighboring gene Src homology 2 domain containing F Neighboring gene STARR-positive B cell enhancer ABC_E10134 Neighboring gene STARR-seq mESC enhancer starr_05555 Neighboring gene STARR-positive B cell enhancer ABC_E1253 Neighboring gene nuclear encoded tRNA histidine 4 (anticodon GTG) Neighboring gene predicted gene, 39918

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hydrogen peroxide production by epidermal dual oxidase 1 regulates nociceptive sensory signals. Pató A, et al. Redox Biol, 2023 Jun. PMID 36958249, Free PMC Article
  2. Duox1 is the main source of hydrogen peroxide in the rat thyroid cell line PCCl3. Rigutto S, et al. Exp Cell Res, 2007 Nov 1. PMID 17643428
  3. Urothelial cells produce hydrogen peroxide through the activation of Duox1. Donkó A, et al. Free Radic Biol Med, 2010 Dec 15. PMID 21146788
  4. DUOX-Mediated Signaling Is Not Required for LPS-Induced Neutrophilic Response in the Airways. Chang S, et al. PLoS One, 2015. PMID 26148206, Free PMC Article
  5. Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema. Schiffers C, et al. Am J Physiol Lung Cell Mol Physiol, 2021 Jul 1. PMID 33951398, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual oxidase 1 is dispensable during Mycobacterium tuberculosis infection in mice.
    Title: Dual oxidase 1 is dispensable during Mycobacterium tuberculosis infection in mice.
  2. Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation.
    Title: Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation.
  3. Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge.
    Title: Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge.
  4. Dual oxidase 1 promotes antiviral innate immunity.
    Title: Dual oxidase 1 promotes antiviral innate immunity.
  5. Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.
    Title: Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.
  6. NADPH oxidase DUOX1 sustains TGF-beta1 signalling and promotes lung fibrosis.
    Title: NADPH oxidase DUOX1 sustains TGF-β1 signalling and promotes lung fibrosis.
  7. Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
    Title: Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
  8. Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.
    Title: Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.
  9. this study shows that Duox1 regulates primary B cell function under the influence of IL-4 through BCR-mediated generation of hydrogen peroxide
    Title: Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.
  10. Cigarette smoke impairs A2A adenosine receptor mediated wound repair through up-regulation of Duox-1 expression.
    Title: Cigarette Smoke Impairs A(2A) Adenosine Receptor Mediated Wound Repair through Up-regulation of Duox-1 Expression.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables superoxide-generating NAD(P)H oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cuticle development ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within reactive oxygen species metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual oxidase 1
Names
dual oxidase 2
NP_001092767.1
XP_006500550.1
XP_030108139.1
XP_036018657.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099297.1 → NP_001092767.1  dual oxidase 1 precursor

    See identical proteins and their annotated locations for NP_001092767.1

    Status: VALIDATED

    Source sequence(s)
    AL844566
    Consensus CDS
    CCDS38222.1
    UniProtKB/TrEMBL
    A2AQ92
    Related
    ENSMUSP00000097060.4, ENSMUST00000099461.4
    Conserved Domains (4) summary
    cd06186
    Location:1277 → 1551
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:32 → 591
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    PLN02292
    Location:1089 → 1412
    PLN02292; ferric-chelate reductase
    cd00051
    Location:820 → 881
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    122143525..122178454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162764.1 → XP_036018657.1  dual oxidase 1 isoform X2

    Conserved Domains (2) summary
    cd09820
    Location:32 → 591
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:820 → 881
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_006500487.4 → XP_006500550.1  dual oxidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006500550.1

    UniProtKB/TrEMBL
    A2AQ92
    Conserved Domains (4) summary
    cd06186
    Location:1277 → 1551
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:32 → 591
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    PLN02292
    Location:1089 → 1412
    PLN02292; ferric-chelate reductase
    cd00051
    Location:820 → 881
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_030252279.2 → XP_030108139.1  dual oxidase 1 isoform X1

    UniProtKB/TrEMBL
    A2AQ92
    Conserved Domains (4) summary
    cd06186
    Location:1277 → 1551
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:32 → 591
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    PLN02292
    Location:1089 → 1412
    PLN02292; ferric-chelate reductase
    cd00051
    Location:820 → 881
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein Strain
Heading Accession and Version

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