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Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 99470, updated on 2-Nov-2024

Summary

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Official Symbol
Magi3provided by MGI
Official Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 3provided by MGI
Primary source
MGI:MGI:1923484
See related
Ensembl:ENSMUSG00000052539 AllianceGenome:MGI:1923484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1634; 4732496O19Rik; 6530407C02Rik
Summary
Enables frizzled binding activity. Acts upstream of or within positive regulation of JUN kinase activity. Located in cell-cell junction. Is expressed in several structures, including central nervous system; gut; hindlimb long bone; lung; and nose. Orthologous to human MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 9.0), bladder adult (RPKM 7.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Magi3 in Genome Data Viewer
Location:
3 F2.2; 3 45.52 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103920575..104127722, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104013259..104220406, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:103718150-103718451 Neighboring gene rosbin, round spermatid basic protein 1 Neighboring gene STARR-seq mESC enhancer starr_08605 Neighboring gene putative homeodomain transcription factor 1, opposite strand Neighboring gene putative homeodomain transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_08606 Neighboring gene STARR-positive B cell enhancer ABC_E9565 Neighboring gene predicted gene, 17956 Neighboring gene STARR-positive B cell enhancer ABC_E1628 Neighboring gene STARR-seq mESC enhancer starr_08607 Neighboring gene predicted gene, 23077 Neighboring gene STARR-seq mESC enhancer starr_08609 Neighboring gene predicted gene 5546 Neighboring gene STARR-seq mESC enhancer starr_08610 Neighboring gene predicted gene, 38412 Neighboring gene phosducin-like 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis. Matsuzawa K, et al. Commun Biol, 2021 Mar 12. PMID 33712709, Free PMC Article
  2. E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer. Wang H, et al. Mol Cancer, 2022 Jul 22. PMID 35864508, Free PMC Article
  3. Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. Franklin JL, et al. Exp Cell Res, 2005 Feb 15. PMID 15652357
  4. Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Adam MG, et al. Circ Res, 2013 Nov 8. PMID 24025447
  5. Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. Wright GJ, et al. Development, 2004 Nov. PMID 15509766

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer.
    Title: E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer.
  2. MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis.
    Title: MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis.
  3. MAGI-3 has a role in efficient trafficking of TGFalpha to the cell surface in polarized epithelial cells.
    Title: Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables frizzled binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of JUN kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Names
MAGI-3
membrane-associated guanylate kinase inverted 3
membrane-associated guanylate kinase-related (MAGI-3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159354.1 → NP_001152826.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001152826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC122324, AC129293, AC162922
    Consensus CDS
    CCDS51031.1
    UniProtKB/Swiss-Prot
    B0V3N7, B0V3N8, Q69ZE1, Q8C0P8, Q9EQJ9
    UniProtKB/TrEMBL
    G5E8T6
    Related
    ENSMUSP00000112934.2, ENSMUST00000121198.8
    Conserved Domains (6) summary
    smart00456
    Location:297 → 329
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:416 → 496
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:345 → 375
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:1023 → 1101
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam10243
    Location:1166 → 1431
    MIP-T3; Microtubule-binding protein MIP-T3
    cl17190
    Location:125 → 199
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. NM_133853.3 → NP_598614.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_598614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122324, AC129293, AC162922
    Consensus CDS
    CCDS17699.1
    UniProtKB/Swiss-Prot
    Q9EQJ9
    Related
    ENSMUSP00000067932.8, ENSMUST00000064371.14
    Conserved Domains (4) summary
    smart00456
    Location:297 → 329
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:416 → 496
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1023 → 1101
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17190
    Location:125 → 199
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    103920575..104127722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQJ9.2 GenPept UniProtKB/Swiss-Prot:Q9EQJ9

Gene LinkOut

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