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DMTF1 cyclin D binding myb like transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 9988, updated on 2-Nov-2024

Summary

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Official Symbol
DMTF1provided by HGNC
Official Full Name
cyclin D binding myb like transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:14603
See related
Ensembl:ENSG00000135164 MIM:608491; AllianceGenome:HGNC:14603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DMP1; DMTF; MRUL; hDMP1
Summary
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Expression
Ubiquitous expression in testis (RPKM 18.8), lymph node (RPKM 11.3) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See DMTF1 in Genome Data Viewer
Location:
7q21.12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (87152453..87196325)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (88402370..88446262)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (86781769..86825641)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator family member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86578298-86578835 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86578836-86579372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18340 Neighboring gene MPRA-validated peak6623 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:86687932-86688432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18342 Neighboring gene MPRA-validated peak6624 silencer Neighboring gene uncharacterized LOC124901689 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:86758408-86759168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86780839-86781402 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86781403-86781964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18343 Neighboring gene DMTF1 antisense RNA 1 Neighboring gene uncharacterized LOC105375384 Neighboring gene NANOG hESC enhancer GRCh37_chr7:86830979-86831516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18345 Neighboring gene transmembrane protein 243 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:86959096-86960295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18346 Neighboring gene TP53 target 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mechanisms regulating DMTF1β/γ expression and their functional interplay with DMTF1α. Li J, et al. Int J Oncol, 2021 Jan. PMID 33367929, Free PMC Article
  2. Emerging roles of DMP1 in lung cancer. Inoue K, et al. Cancer Res, 2008 Jun 15. PMID 18559489, Free PMC Article
  3. Role of DMP1 and its future in lung cancer diagnostics. Sugiyama T, et al. Expert Rev Mol Diagn, 2008 Jul. PMID 18598225, Free PMC Article
  4. Dmp1 and tumor suppression. Inoue K, et al. Oncogene, 2007 Jun 28. PMID 17237816, Free PMC Article
  5. From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform. Tian N, et al. Int J Mol Sci, 2017 Mar 2. PMID 28257090, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanisms regulating DMTF1beta/gamma expression and their functional interplay with DMTF1alpha.
    Title: Mechanisms regulating DMTF1β/γ expression and their functional interplay with DMTF1α.
  2. Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53.
    Title: Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53.
  3. the results of the study demonstrated that miR6753p directly regulated the expression of DMTF1, which contributed to the further regulation of Colorectal cancer cell proliferation.
    Title: miR‑675 promotes colorectal cancer cell growth dependent on tumor suppressor DMTF1.
  4. DMTF1 is hemizygously deleted in 35-42% of human cancers and is associated with longer survival. [review]
    Title: c-MYB and DMTF1 in Cancer.
  5. Cisplatin sensitivity in breast cancer cells is associated with a DMTF1beta splice variant expression.
    Title: Cisplatin sensitivity in breast cancer cells is associated with particular DMTF1 splice variant expression.
  6. Study demonstrated that an alternative cyclin D-binding myb-like transcription factor 1 (DMTF1) pre-mRNA splicing isoform, DMTF1 beta, is increasingly expressed in breast cancer and promotes mammary tumorigenesis in a transgenic mouse model. [review].
    Title: From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform.
  7. Low DMTF1 expression is associated with in bladder cancer.
    Title: MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1.
  8. findings imply that DMP1alpha- and beta-ratios are tightly regulated in hematopoietic cells and DMP1beta antagonizes DMP1alpha transcriptional regulation of ARF resulting in the alteration of cellular control with a gain in proliferation
    Title: Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation.
  9. This study reveals a pivotal role of combined Dmp1 loss and cyclin D1 overexpression in breast cancer.
    Title: Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer.
  10. LOH for hDMP1 was associated with luminal A category and longer relapse-free survival
    Title: Prognostic value of the hDMP1-ARF-Hdm2-p53 pathway in breast cancer.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.
EBI GWAS Catalog
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25188, FLJ41265, FLJ76054

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cyclin-D-binding Myb-like transcription factor 1
Names
cyclin D-binding Myb-like protein
cyclin-D-interacting Myb-like protein 1
hDMTF1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029536.1 RefSeqGene

    Range
    5093..48965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142326.2 → NP_001135798.1  cyclin-D-binding Myb-like transcription factor 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a 5' coding exon, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b) with a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC005076, AF052102, AK296211, BC070064
    Consensus CDS
    CCDS47633.1
    UniProtKB/TrEMBL
    E7EPA0
    Related
    ENSP00000412532.2, ENST00000432937.6
    Conserved Domains (4) summary
    smart00717
    Location:186 → 242
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:250 → 300
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00249
    Location:186 → 241
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:140 → 196
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  2. NM_001142327.2 → NP_001135799.1  cyclin-D-binding Myb-like transcription factor 1 isoform a

    See identical proteins and their annotated locations for NP_001135799.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AF084530, BC007418
    Consensus CDS
    CCDS5601.1
    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
    UniProtKB/TrEMBL
    E7EPA0
    Related
    ENSP00000332171.7, ENST00000331242.12
    Conserved Domains (3) summary
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:89 → 438
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  3. NM_021145.4 → NP_066968.3  cyclin-D-binding Myb-like transcription factor 1 isoform a

    See identical proteins and their annotated locations for NP_066968.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a, also known as DMP1alpha). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC005076, BC007447, BC070064, DB061156
    Consensus CDS
    CCDS5601.1
    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
    UniProtKB/TrEMBL
    E7EPA0
    Related
    ENSP00000378193.5, ENST00000394703.9
    Conserved Domains (3) summary
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:89 → 438
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

RNA

  1. NR_024549.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate internal exons and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as in variant 1, would result in nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF202145, BC007418
    Related
    ENST00000447863.5

  2. NR_024550.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate internal exons and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as in variant 1, would result in nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF202144, BC007418
    Related
    ENST00000579677.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    87152453..87196325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421106.1 → XP_047277062.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  2. XM_047421102.1 → XP_047277058.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  3. XM_047421123.1 → XP_047277079.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  4. XM_047421100.1 → XP_047277056.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  5. XM_024447017.2 → XP_024302785.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
    UniProtKB/TrEMBL
    E7EPA0
    Conserved Domains (3) summary
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:89 → 438
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  6. XM_047421107.1 → XP_047277063.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  7. XM_047421111.1 → XP_047277067.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  8. XM_047421103.1 → XP_047277059.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  9. XM_024447018.2 → XP_024302786.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
    UniProtKB/TrEMBL
    E7EPA0
    Conserved Domains (3) summary
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:89 → 438
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  10. XM_047421116.1 → XP_047277072.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  11. XM_024447022.2 → XP_024302790.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
    UniProtKB/TrEMBL
    E7EPA0
    Conserved Domains (3) summary
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:89 → 438
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  12. XM_047421131.1 → XP_047277087.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  13. XM_024447016.2 → XP_024302784.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
    UniProtKB/TrEMBL
    E7EPA0
    Conserved Domains (3) summary
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:89 → 438
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  14. XM_047421126.1 → XP_047277082.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  15. XM_047421119.1 → XP_047277075.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  16. XM_047421133.1 → XP_047277089.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

  17. XM_011516737.1 → XP_011515039.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011515039.1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
    UniProtKB/TrEMBL
    E7EPA0
    Conserved Domains (3) summary
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:89 → 438
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  18. XM_017012868.1 → XP_016868357.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    E7EPA0
    Conserved Domains (3) summary
    COG5147
    Location:105 → 438
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain

  19. XM_047421118.1 → XP_047277074.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  20. XM_047421134.1 → XP_047277090.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

  21. XM_024447020.2 → XP_024302788.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
    UniProtKB/TrEMBL
    E7EPA0
    Conserved Domains (3) summary
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:89 → 438
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  22. XM_047421128.1 → XP_047277084.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  23. XM_047421117.1 → XP_047277073.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  24. XM_047421122.1 → XP_047277078.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  25. XM_011516739.4 → XP_011515041.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    See identical proteins and their annotated locations for XP_011515041.1

    UniProtKB/TrEMBL
    E7EPA0
    Conserved Domains (4) summary
    smart00717
    Location:233 → 289
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:297 → 347
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00249
    Location:233 → 288
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:187 → 243
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  26. XM_017012870.3 → XP_016868359.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

    UniProtKB/TrEMBL
    E7EPA0

  27. XM_047421108.1 → XP_047277064.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  28. XM_047421101.1 → XP_047277057.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  29. XM_047421104.1 → XP_047277060.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  30. XM_047421125.1 → XP_047277081.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  31. XM_024447019.2 → XP_024302787.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
    UniProtKB/TrEMBL
    E7EPA0
    Conserved Domains (3) summary
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:89 → 438
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  32. XM_047421120.1 → XP_047277076.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  33. XM_047421112.1 → XP_047277068.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  34. XM_047421105.1 → XP_047277061.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  35. XM_047421127.1 → XP_047277083.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  36. XM_024447021.2 → XP_024302789.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
    UniProtKB/TrEMBL
    E7EPA0
    Conserved Domains (3) summary
    pfam00249
    Location:274 → 329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228 → 284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl28544
    Location:89 → 438
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

  37. XM_047421130.1 → XP_047277086.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  38. XM_047421121.1 → XP_047277077.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  39. XM_047421099.1 → XP_047277055.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  40. XM_047421109.1 → XP_047277065.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  41. XM_047421110.1 → XP_047277066.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  42. XM_047421113.1 → XP_047277069.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  43. XM_047421124.1 → XP_047277080.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  44. XM_047421129.1 → XP_047277085.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  45. XM_047421114.1 → XP_047277070.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  46. XM_047421115.1 → XP_047277071.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  47. XM_047421132.1 → XP_047277088.1  cyclin-D-binding Myb-like transcription factor 1 isoform X4

  48. XM_047421135.1 → XP_047277091.1  cyclin-D-binding Myb-like transcription factor 1 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    88402370..88446262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359466.1 → XP_054215441.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  2. XM_054359456.1 → XP_054215431.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  3. XM_054359467.1 → XP_054215442.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  4. XM_054359469.1 → XP_054215444.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  5. XM_054359461.1 → XP_054215436.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  6. XM_054359479.1 → XP_054215454.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  7. XM_054359465.1 → XP_054215440.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  8. XM_054359494.1 → XP_054215469.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  9. XM_054359459.1 → XP_054215434.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  10. XM_054359489.1 → XP_054215464.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  11. XM_054359482.1 → XP_054215457.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  12. XM_054359498.1 → XP_054215473.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

  13. XM_054359454.1 → XP_054215429.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  14. XM_054359490.1 → XP_054215465.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  15. XM_054359481.1 → XP_054215456.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  16. XM_054359500.1 → XP_054215475.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

  17. XM_054359460.1 → XP_054215435.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  18. XM_054359492.1 → XP_054215467.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  19. XM_054359480.1 → XP_054215455.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  20. XM_054359485.1 → XP_054215460.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  21. XM_054359475.1 → XP_054215450.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  22. XM_054359497.1 → XP_054215472.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

  23. XM_054359455.1 → XP_054215430.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  24. XM_054359464.1 → XP_054215439.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  25. XM_054359486.1 → XP_054215461.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  26. XM_054359458.1 → XP_054215433.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  27. XM_054359462.1 → XP_054215437.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  28. XM_054359470.1 → XP_054215445.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  29. XM_054359471.1 → XP_054215446.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  30. XM_054359472.1 → XP_054215447.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  31. XM_054359495.1 → XP_054215470.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  32. XM_054359473.1 → XP_054215448.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  33. XM_054359474.1 → XP_054215449.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  34. XM_054359493.1 → XP_054215468.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  35. XM_054359484.1 → XP_054215459.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  36. XM_054359457.1 → XP_054215432.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  37. XM_054359463.1 → XP_054215438.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  38. XM_054359488.1 → XP_054215463.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  39. XM_054359468.1 → XP_054215443.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

  40. XM_054359483.1 → XP_054215458.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  41. XM_054359477.1 → XP_054215452.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  42. XM_054359478.1 → XP_054215453.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  43. XM_054359487.1 → XP_054215462.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  44. XM_054359476.1 → XP_054215451.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

  45. XM_054359491.1 → XP_054215466.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

  46. XM_054359499.1 → XP_054215474.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

  47. XM_054359502.1 → XP_054215477.1  cyclin-D-binding Myb-like transcription factor 1 isoform X7

  48. XM_054359496.1 → XP_054215471.1  cyclin-D-binding Myb-like transcription factor 1 isoform X4

  49. XM_054359501.1 → XP_054215476.1  cyclin-D-binding Myb-like transcription factor 1 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y222.1 GenPept UniProtKB/Swiss-Prot:Q9Y222

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