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    SUCLA2 succinate-CoA ligase ADP-forming subunit beta [ Homo sapiens (human) ]

    Gene ID: 8803, updated on 7-Jan-2024

    Summary

    Official Symbol
    SUCLA2provided by HGNC
    Official Full Name
    succinate-CoA ligase ADP-forming subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:11448
    See related
    Ensembl:ENSG00000136143 MIM:603921; AllianceGenome:HGNC:11448
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A-SCS; A-BETA; MTDPS5; LINC00444; SCS-betaA
    Summary
    Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 24.1), fat (RPKM 23.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SUCLA2 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (47942656..48001273, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (47163055..47221676, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48516791..48575409, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:48355836-48356352 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:48356353-48356869 Neighboring gene ribosomal protein L27a pseudogene 8 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:48387787-48388329 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:48431764-48432963 Neighboring gene long intergenic non-protein coding RNA 562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7719 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:48575750-48576949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:48577621-48578218 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:48578817-48579414 Neighboring gene uncharacterized LOC124903172 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:48610990-48611866 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:48611867-48612742 Neighboring gene nudix hydrolase 15 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:48640162-48641361 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:48646101-48647300 Neighboring gene MED4 antisense RNA 1 Neighboring gene mediator complex subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of aging.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 NL4-3 replication is restricted by SUCLA2 as enhanced replication was discovered when SUCLA2 is deleted through CRISPR/Cas9 genome editing in primary CD4+ T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables succinate-CoA ligase (ADP-forming) activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in succinate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in succinyl-CoA catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in succinyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in succinyl-CoA pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of succinate-CoA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of succinate-CoA ligase complex (ADP-forming) NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
    Names
    ATP-specific succinyl-CoA synthetase subunit beta
    ATP-specific succinyl-CoA synthetase, beta subunit
    long intergenic non-protein coding RNA 444
    mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta
    renal carcinoma antigen NY-REN-39
    succinate-CoA ligase ADP-forming beta subunit
    succinate-CoA ligase beta subunit
    succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
    succinyl-CoA synthetase beta-A chain
    NP_003841.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008241.2 RefSeqGene

      Range
      5000..63617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003850.3NP_003841.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial precursor

      See identical proteins and their annotated locations for NP_003841.1

      Status: REVIEWED

      Source sequence(s)
      AL157369
      Consensus CDS
      CCDS9406.1
      UniProtKB/Swiss-Prot
      B2RDE7, O95194, Q5T9Q4, Q5T9Q6, Q9NV21, Q9NVP7, Q9P2R7
      UniProtKB/TrEMBL
      E5KS60, Q6N0B1
      Related
      ENSP00000494360.1, ENST00000646932.1
      Conserved Domains (1) summary
      PRK00696
      Location:55445
      sucC; succinyl-CoA synthetase subunit beta; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      47942656..48001273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      47163055..47221676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)