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    SERHL serine hydrolase like (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 94009, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SERHLprovided by HGNC
    Official Full Name
    serine hydrolase like (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:14408
    See related
    Ensembl:ENSG00000293485 MIM:607979; AllianceGenome:HGNC:14408
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HS126B42; BK126B4.1; BK126B4.2; dJ222E13.1
    Summary
    Predicted to enable hydrolase activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 17.0), ovary (RPKM 13.4) and 25 other tissues See more
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    Genomic context

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    See SERHL in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (42500579..42512560)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (42981559..42993542)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (42896585..42908566)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1538 Neighboring gene NFAT activating protein with ITAM motif 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42821196-42821779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19163 Neighboring gene uncharacterized LOC101927344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42834221-42834722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42836600-42837599 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42840373-42841139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19167 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:42894685-42895205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:42895291-42895792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13826 Neighboring gene uncharacterized LOC101927372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42900600-42901233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42904339-42905038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42905039-42905737 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42909821-42910364 Neighboring gene uncharacterized LOC124900479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19168 Neighboring gene Sharpr-MPRA regulatory region 9885 Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42923851-42924598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42929412-42929912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42929913-42930413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42956436-42957120 Neighboring gene serine hydrolase like 2 Neighboring gene RN7SK pseudogene 80

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study identified copy number variants important for appendicular lean mass. Ran S, et al. PLoS One, 2014. PMID 24626161, Free PMC Article
    2. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. Collins JE, et al. Genome Res, 2003 Jan. PMID 12529303, Free PMC Article
    3. A genome annotation-driven approach to cloning the human ORFeome. Collins JE, et al. Genome Biol, 2004. PMID 15461802, Free PMC Article
    4. The DNA sequence of human chromosome 22. Dunham I, et al. Nature, 1999 Dec 2. PMID 10591208
    5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GIMAP1 and SERHL variants may be important for appendicular lean mass
      Title: Genome-wide association study identified copy number variants important for appendicular lean mass.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • kraken-like
    • serine hydrolase-like

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027786.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL365513, DA273263
      Related
      ENST00000359906.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      42500579..42512560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      42981559..42993542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_170694.1: Suppressed sequence

      Description
      NM_170694.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NQF3.1 GenPept UniProtKB/Swiss-Prot:Q9NQF3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials