| LAB is a critical, LAT-independent regulator of TREM-2 signaling and macrophage development capable of controlling subsequent inflammatory responses | The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.
Whittaker GC, Orr SJ, Quigley L, Hughes L, Francischetti IM, Zhang W, McVicar DW., Free PMC Article | 03/1/2010 |
| contributes to the immune response against Salmonella in a mouse model | DAP10- and DAP12-associated receptors in innate immunity.
Lanier LL., Free PMC Article | 01/21/2010 |
| TREM2 conferred phagocytic activity of neuronal cells demonstrating that TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells | A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia.
Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE., Free PMC Article | 01/21/2010 |
| Trem2/DAP12 expression is detected in embryonic day 14 CNS mRNA. Trem2/DAP12 positive microglia are found in very close apposition with CNP+ oligodendrocytes prior to myelination (post-natal day 1). | Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease.
Thrash JC, Torbett BE, Carson MJ., Free PMC Article | 01/21/2010 |
| Trem2 signaling is an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary | Efficient colonic mucosal wound repair requires Trem2 signaling.
Seno H, Miyoshi H, Brown SL, Geske MJ, Colonna M, Stappenbeck TS., Free PMC Article | 01/21/2010 |
| signaling through DAP12, TREM-2, and the downstream protein tyrosine kinase Syk is required for the cytokine-induced formation of giant cells | Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.
Helming L, Tomasello E, Kyriakides TR, Martinez FO, Takai T, Gordon S, Vivier E., Free PMC Article | 01/21/2010 |
| Salmonella typhimurium induces ROS through a pathway that requires both triggering receptor expressed on myeloid cells 2 (TREM2) and DAP12. | The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12.
Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD., Free PMC Article | 01/21/2010 |
| In microglial cells Trem2 is distributed intracellularly in the Golgi complex and in a population of exocytic vesicles distinct from endosomes and lysosomes, where is continuously translocated to and recycled from the cell surface. | Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation.
Prada I, Ongania GN, Buonsanti C, Panina-Bordignon P, Meldolesi J. | 01/21/2010 |
| TREM2-DAP12 signals regulate both osteoclast formation and function. | TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. | 01/21/2010 |
| IL-4-mediated dendritic cell-activated natural killer cell activity is significantly blocked by soluble triggering receptor expressed on myeloid cell 2 (TREM2) Fc molecules in vitro. | IL-4 confers NK stimulatory capacity to murine dendritic cells: a signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 molecules.
Terme M, Tomasello E, Maruyama K, Crépineau F, Chaput N, Flament C, Marolleau JP, Angevin E, Wagner EF, Salomon B, Lemonnier FA, Wakasugi H, Colonna M, Vivier E, Zitvogel L. | 01/21/2010 |
| OSCAR but not TREM-2 is involved in the positive feedback loop of the immunoreceptor-NFATc1 pathway during osteoclastogenesis | Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis.
Kim Y, Sato K, Asagiri M, Morita I, Soma K, Takayanagi H. | 01/21/2010 |
| Interaction of TREM-2 and its ligand results in an inhibitory signal that can reduce the inflammatory response. | Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.
Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. | 01/21/2010 |
| TREM-2 is expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation. | Cutting edge: TREM-2 attenuates macrophage activation.
Turnbull IR, Gilfillan S, Cella M, Aoshi T, Miller M, Piccio L, Hernandez M, Colonna M. | 01/21/2010 |
| TREM-2a and TREM-2b binding to both Gram-positive and Gram-negative bacteria is disrupted by anionic bacterial products or other anionic carbohydrates and suggests that TREM-2 recognizes pathogens via charged carbohydrates expressed on pathogen surface. | Pattern recognition by TREM-2: binding of anionic ligands.
Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. | 01/21/2010 |