| No mutation in the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with hereditary sensory and autonomic neuropathy type V. | No mutation in the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with hereditary sensory and autonomic neuropathy type V.
Toscano E, Simonati A, Indo Y, Andria G. | 01/21/2010 |
| These results indicate that Fyn is activated by G-protein-coupled receptor stimulation and is responsible for transactivation of TrkA receptors on intracellular membranes. | A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling.
Rajagopal R, Chao MV. | 01/21/2010 |
| Data provide further evidence regarding the clinical role of p-TrkA in ovarian carcinoma. | The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma.
Ødegaard E, Staff AC, Abeler VM, Kopolovic J, Onsrud M, Lazarovici P, Davidson B. | 01/21/2010 |
| Overexpression in salivary adenoid cystic carcinoma may constitute a reason for perineural invasion | Nerve growth factor and tyrosine kinase A in human salivary adenoid cystic carcinoma: expression patterns and effects on in vitro invasive behavior.
Wang L, Sun M, Jiang Y, Yang L, Lei D, Lu C, Zhao Y, Zhang P, Yang Y, Li J. | 01/21/2010 |
| trkA(NGFR) and p75(NTR) have roles with nerve growth factor in the healing process as a result of injury [review] | Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate.
Micera A, Lambiase A, Stampachiacchiere B, Bonini S, Bonini S, Levi-Schaffer F. | 01/21/2010 |
| Constitutively activated Scr facilitates NGF-induced phosphorylation of TRKA. | Constitutively active Src facilitates NGF-induced phosphorylation of TrkA and causes enhancement of the MAPK signaling in SK-N-MC cells.
Tsuruda A, Suzuki S, Maekawa T, Oka S. | 01/21/2010 |
| These results strongly indicate that the expression level of PS1 protein has a cross talk with the Trk-dependent neuroprotective intracellular signaling pathway. | Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein.
Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H. | 01/21/2010 |
| Data show that nerve growth factor activation of the TrkA receptor involves two distinct signalling pathways, and that both are necessary to induce airway smooth muscle cell proliferation. | TrkA signalling pathways in human airway smooth muscle cell proliferation.
Freund-Michel V, Bertrand C, Frossard N. | 01/21/2010 |
| a novel alternative TrkA splice variant, TrkAIII, that exhibits expression restricted to undifferentiated early neural progenitors, human neuroblastomas, and a subset of other neural crest-derived tumors | TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR. | 01/21/2010 |
| Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive disorder caused by mutations in the neurotrophic tyrosine receptor kinase 1 (NTRK1) gene which encodes the receptor for nerve growth factor (NGF). | Congenital insensitivity to pain with Anhidrosis (NTRK1 mutation) and early onset renal disease: clinical report on three sibs with a 25-year follow-up in one of them.
Barone R, Lempereur L, Anastasi M, Parano E, Pavone P. | 01/21/2010 |
| CEP-701 could be used to reduce the metastasis formation in advanced prostatic cncer by inhibiting NTRK1. | Tyrosine kinase inhibitor CEP-701 blocks the NTRK1/NGF receptor and limits the invasive capability of prostate cancer cells in vitro.
Festuccia C, Muzi P, Gravina GL, Millimaggi D, Speca S, Dolo V, Ricevuto E, Vicentini C, Bologna M. | 01/21/2010 |
| role in tyrosine phosphorylation and processing of beta-APP | Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP.
Tarr PE, Contursi C, Roncarati R, Noviello C, Ghersi E, Scheinfeld MH, Zambrano N, Russo T, D'Adamio L. | 01/21/2010 |
| Nerve growth factor decreases N-myc levels in TRKA-infected neuroblastoma cells and decreases cell proliferation via a MAPK path. | NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number.
Woo CW, Lucarelli E, Thiele CJ. | 01/21/2010 |
| genetics of hereditary sensory and autonomic neuropathy type IV: clinical, biological and molecular aspects of mutations (REVIEW) | Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor.
Indo Y. | 01/21/2010 |
| genes are rearranged in papillary thyroid cancer. | Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer.
Frattini M, Ferrario C, Bressan P, Balestra D, De Cecco L, Mondellini P, Bongarzone I, Collini P, Gariboldi M, Pilotti S, Pierotti MA, Greco A. | 01/21/2010 |
| Light and electron microscopy immunohistochemistry showed that human tonsillar samples were positive for TrkA. | Neurotrophins and neurotransmitters in human palatine tonsils: an immunohistochemical and RT-PCR analysis.
Bronzetti E, Artico M, Pompili E, Felici LM, Stringaro A, Bosco S, Magliulo G, Colone M, Arancia G, Vitale M, Fumagalli L. | 01/21/2010 |
| TrkA is expressed in pleural and peritoneal effusions and in advanced-stage ovarian carcinoma. | Expression levels of the nerve growth factor receptors TrkA and p75 in effusions and solid tumors of serous ovarian carcinoma patients.
Davidson B, Lazarovici P, Ezersky A, Nesland JM, Berner A, Risberg B, Tropé CG, Kristensen GB, Goscinski M, van de Putte G, Reich R. | 01/21/2010 |
| a role for TrkA activation in a subset of melanomas as a predictor of an aggressive phenotype and poor outcome | Expression of activated TrkA protein in melanocytic tumors: relationship to cell proliferation and clinical outcome.
Flørenes VA, Maelandsmo GM, Holm R, Reich R, Lazarovici P, Davidson B. | 01/21/2010 |
| CIPA patients had a branch site mutation in intron 7 (IVS7-33 T-->A) of the NTRK1 gene and a marked reduction of small myelinated and unmyelinated fibers and a relatively increased axon size. This is the first CIPA family encountered in Taiwan | Congenital insensitivity to pain with anhidrosis in Taiwan: a morphometric and genetic study.
Guo YC, Liao KK, Soong BW, Tsai CP, Niu DM, Lee HY, Lin KP. | 01/21/2010 |
| congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency | Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
Indo Y, Mardy S, Miura Y, Moosa A, Ismail EA, Toscano E, Andria G, Pavone V, Brown DL, Brooks A, Endo F, Matsuda I. | 01/21/2010 |
| Expression of TrkA in pancreatic cancer is a marker of tumor aggressiveness. | Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer.
Dang C, Zhang Y, Ma Q, Shimahara Y. | 01/21/2010 |
| These data strongly indicate that these anti-neutral glycosphingolipids antibodies have a functional impact on nerve growth factor (NGF)-Trk-mediated intracellular signal transduction pathway. | Detection of new anti-neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors.
Mihara T, Ueda A, Hirayama M, Takeuchi T, Yoshida S, Naito K, Yamamoto H, Mutoh T. | 01/21/2010 |
| Phosphorylated TrkA is localized at the mitotic apparatus in a human glioma cell line. | Localization of NGF and TrkA at mitotic apparatus in human glioma cell line U251.
Zhang Z, Yang Y, Gong A, Wang C, Liang Y, Chen Y. | 01/21/2010 |
| TrkA as a life and death receptor: receptor dose as a mediator of function. | TrkA as a life and death receptor: receptor dose as a mediator of function.
Yan C, Liang Y, Nylander KD, Schor NF. | 01/21/2010 |
| biologic effects of trkA neurotrophin receptor activation by nerve growth factor in a newly established Askin tumor cell line | Activation of trkA induces differentiation and inhibits the growth of JK-GMS Askin tumor cells.
Kim GJ, Kim CJ, Cho SY, Chung IP, Park SH, Lee MJ, Chi JG. | 01/21/2010 |